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High-sensitivity paracetamol sensor based on Pd/graphene oxide nanocomposite as an enhanced electrochemical sensing platform

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WOS被引频次:77
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成果类型:
期刊论文
作者:
Li, Junhua;Liu, Jinlong;Tan, Gongrong;Jiang, Jianbo;Peng, Sanjun;Deng, Miao;Qian, Dong;Feng, Yonglan;Liu, Youcai
通讯作者:
Qian, D
作者机构:
[Qian, Dong; Li, Junhua] State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China
[Deng, Miao; Liu, Youcai; Tan, Gongrong; Qian, Dong; Jiang, Jianbo; Peng, Sanjun; Li, Junhua; Liu, Jinlong] College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
[Li, Junhua; Feng, Yonglan] Department of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, China
通讯机构:
[Qian, Dong] State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China. Electronic address:
[Liu, Youcai] College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China. Electronic address:
语种:
英文
关键词:
Pd nanoparticles;Graphene oxide;Electrochemical sensor;Paracetamol
期刊:
Biosensors and Bioelectronics
ISSN:
0956-5663
年:
2014
卷:
54
页码:
468-475
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:化学;WOS学科类别:Biophysics;Biotechnology & Applied Microbiology;Chemistry, Analytical;Electrochemistry;Nanoscience & Nanotechnology
入藏号:
WOS:000333071500071;EI:20135017080578;PMID:24315879
基金类别:
National Natural Science Foundation of China [21171174]; Provincial Natural Science Foundation of Hunan [09113024, 13JJ3112]; Scientific Research Project of Education Department of Hunan Province [12C0536, 13K105]; Provincial Environmental Science and Technology Foundation of Hunan; Open-end Fund for the Valuable and Precision Instruments of Central South University
机构署名:
本校为其他机构
院系归属:
化学与材料科学学院
摘要:
Well-dispersed Pd nanoparticles were facilely anchored on graphene oxide (Pd/GO) via a one-pot chemical reduction of the Pd2+ precursor without any surfactants and templates. The morphology and composition of the Pd/GO nanocomposite were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FUR) and energy dispersive analysis of X-ray (EDX). The stepwise fabrication process of the Pd/GO modified electrode and its electrochemical sensing performance towards paracetamol was evaluated using electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The experimental results indicate that the as-synthesized Pd nanoparticles are relatively uniform in size (5-10 nm) without large aggregation and uniformly distributed in the carbon matrix with the overall Pd content of 28.77 wt% in Pd/GO. Compared with the GO modified electrode, the Pd/GO modified electrode shows a better electrocatalytic activity to the oxidation of paracetamol with lower oxidation potential and larger peak current, so the Pd/GO nanocomposite can be used as an enhanced sensing platform for the electrochemical determination of paracetamol. The kinetic parameters of the paracetamol electro-oxidation at Pd/GO electrode were studied in detail, and the determination conditions were optimized. Under the optimal conditions, the oxidation peak current is linear to the paracetamol concentration in the ranges of 0.005-0.5 mu M and 0.5-80.0 mu M with a detection limit of 2.2 nM. Based on the high sensitivity and good selectivity of the Pd/GO modified electrode, the proposed method was successfully applied to the determination of paracetamol in commercial tablets and human urines, and the satisfactory results confirm the applicability of this sensor in practical analysis. (C) 2013 Elsevier B.V. All rights reserved.
参考文献:
Abdelaleem EA, 2013, ANAL METHODS-UK, V5, P541, DOI 10.1039/c2ay26085a
Vetrichelvan T, 2013, INT J PHARM PHARM SC, V5, P488
Andersen Ane Birgitte Telen, 2012, Clin Epidemiol, V4, P33, DOI 10.2147/CLEP.S28312
Arvand M, 2013, COLLOID SURFACE B, V103, P84, DOI 10.1016/j.colsurfb.2012.10.024
Atta NF, 2011, J MATER CHEM, V21, P13015, DOI 10.1039/c1jm11795e

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