Silver coordination complex amplified electrochemiluminescence sensor for sensitive detection of coenzyme A and histone acetyltransferase activity

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成果类型：

期刊论文

作者：

Chen, Hongjun;Liu, Xiu;Li, Wang*;Peng, Yan;Nie, Zhou

通讯作者：

Li, Wang

作者机构：

[Chen, Hongjun] Hunan Univ Humanities Sci & Technol, Sch Mat & Environm Engn, Hunan Prov Key Lab Fine Ceram & Powder Mat, Loudi 417000, Peoples R China.

[Chen, Hongjun; Li, Wang; Nie, Zhou] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Liu, Xiu] Hunan Univ Humanities Sci & Technol, CICFWC, Key Lab Pesticide Harmless Applicat, Loudi 417000, Peoples R China.

[Li, Wang] Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Changsha 410004, Hunan, Peoples R China.

[Peng, Yan] Hengyang Normal Univ, Coll Econ & Management, Hengyang 421008, Peoples R China.

通讯机构：

[Li, Wang] C

Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

ECL amplification;Histone acetyltransferase;Signal-on;Silver coordination complex

期刊：

Biosensors and Bioelectronics

ISSN：

0956-5663

年：

2019

卷：

126

页码：

535-542

DOI：

10.1016/j.bios.2018.11.003

基金类别：

This work was financially supported by the National Natural Science Foundation of China (Nos. 21305037 , 21475037 , and 21804145 ).

机构署名：

本校为其他机构

院系归属：

经济与管理学院

摘要：

A kind of coenzyme A (CoA)-silver coordination complex (CoA-Ag) was in-situ developed and verified to accelerate the electron transferring and electrochemical catalysis of H2O2 decomposition to enhance the cathode ECL intensity of CdTe@CdS QDs. Afterward, a convenient label-free signal-on ECL approach was constructed for CoA detection with excellent specificity. In addition, the unique ECL enhancing phenomenon was also proposed to assay the enzymatic activity of histone acetyltransferases (HAT) and screen relevant inhibitors, exhibiting a promising potential in the practical application of bio...

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Silver coordination complex amplified electrochemiluminescence sensor for sensitive detection of coenzyme A and histone acetyltransferase activity

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