A Clinically Translatable Ternary Platinum(IV) Prodrug for Synergistically Reversing Drug Resistance

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成果类型：

期刊论文

作者：

Liu, Ying;Wang, Dun;Liu, Hongbing;Liu, Li;Li, Shuang;...

通讯作者：

Cui-Yun Yu<&wdkj&>Hua Wei

作者机构：

[Liu, Hongbing; Lu, Linyin; Wei, Hua; Liu, Ying; Liu, Li; Liu, Xuyue; Li, Shuang; He, Lifang; Wang, Dun; Zhou, Zongtao; He, Dongxiu; Yu, Cui-Yun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Liu, Hongbing; Lu, Linyin; Wei, Hua; Liu, Ying; Liu, Li; Liu, Xuyue; Li, Shuang; Wang, Dun; Zhou, Zongtao; He, Dongxiu; Yu, Cui-Yun] Univ South China, Sch Pharmaceut Sci, Hengyang 421001, Peoples R China.

[He, Lifang] Hengyang Normal Univ, Coll Life Sci, Hengyang 421001, Peoples R China.

通讯机构：

[Cui-Yun Yu; Hua Wei] H

Hengyang Medical School, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & School of Pharmaceutical Science, University of South China, Hengyang 421001, China

语种：

英文

期刊：

JOURNAL OF MEDICINAL CHEMISTRY

ISSN：

0022-2623

年：

2023

卷：

期：

页码：

4045-4058

DOI：

10.1021/acs.jmedchem.2c01924

基金类别：

Thousand Young Talent Program; Outstanding Youth Fund of Natural Science Foundation of Hunan Province [2017JJ1024]; Foundation of Hunan Provincial Natural Science Foundation of China [2022JJ40381, 2020JJ6042]; National Natural Science Foundation of China [22101127]; Key R&D Program of Hunan Province [2021SK2036]; National Innovation and Entrepreneurship Training Program for Undergraduate [210XCX336]; Hunan Provincial Innovation and Entrepreneurship Training Program for Undergraduate [S202210555291]

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摘要：

Scalable production of a clinically translatable formulation with enhanced therapeutic efficacy against cisplatin-resistant tumors without the use of any clinically unapproved reagents and additional manipulation remains a challenge. For this purpose, we report herein the construction of TPP-Pt-acetal-CA based on all commercially available, clinically approved reagents consisting of a cinnamaldehyde (CA) unit for reactive oxygen species generation, a mitochondrially targeted triphenylphosphonium (TPP)-modified Pt(IV) moiety for mitochondrial dysfunction, and an intracellular acidic pH-cleavabl...

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A Clinically Translatable Ternary Platinum(IV) Prodrug for Synergistically Reversing Drug Resistance

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