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Stabilized enzyme immobilization on micron-size PSt-GMA microspheres: Different methods to improve the carriers' surface biocompatibility

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成果类型:
期刊论文
作者:
Peng, Gang;Hou, Xiaohui;Liu, Bailing*;Chen, Hualin;Luo, Rong
通讯作者:
Liu, Bailing
作者机构:
[Peng, Gang] Hengyang Normal Univ, Dept Chem & Mat Sci, Hengyang 421008, Peoples R China.
[Peng, Gang] Hengyang Normal Univ, Hunan Prov Coll, Key Lab Funct Organomet Mat, Hengyang 421008, Peoples R China.
[Chen, Hualin; Peng, Gang; Liu, Bailing; Luo, Rong; Hou, Xiaohui] Chinese Acad Sci, Chengdu Inst Organ Chem, Renminnan Rd 9, Chengdu 610041, Sichuan, Peoples R China.
通讯机构:
[Liu, Bailing] C
Chinese Acad Sci, Chengdu Inst Organ Chem, Renminnan Rd 9, Chengdu 610041, Sichuan, Peoples R China.
语种:
英文
期刊:
RSC Advances
ISSN:
2046-2069
年:
2016
卷:
6
期:
94
页码:
91431-91439
基金类别:
Science Foundation of Hengyang Normal University [13B29]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2016JJ6014]; Aid programs for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province; Key Discipline of Hunan Province
机构署名:
本校为第一机构
院系归属:
化学与材料科学学院
摘要:
Stabilized immobilization of biomacromolecules on carriers with appropriate orientation and minimum conformational changes is very important in the biochemical and biomedical fields. In this study, PSt-GMA(polystyrene-glycidyl methacrylate) microspheres were utilized as the carriers of immobilizing glucose oxidase (GOD). To improve the carrier's biocompatibility, anionic sulfonate groups and different length of spacer arms were introduced onto the microspheres' surface. The effect of carrier surface properties on the activity and stability of immobilized enzymes was investigated. The results s...

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