Human inadaptability to exercise induces not only the loss of iron but also the dysfunction of iron transport. The latter maybe conduces to iron excessive accumulation in the liver and muscle and iron-deficiency in the bone marrow. The iron distribution with extreme disparity can be seen as one of the reasons for exercise-induced anemia, long-term sports training improves the disordered iron distribution by upregulating transferrin and its receptor expression, and by enhancing transferrin-free iron uptake, and by transfering iron from iron-rich tissue to bone marrow, these adaptabilities to tr...
