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STNMDA: A Novel Model for Predicting Potential Microbe-Drug Associations with Structure-Aware Transformer

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成果类型:
期刊论文
作者:
Liu Fan;Xiaoyu Yang;Lei Wang;Xianyou Zhu
作者机构:
[Xianyou Zhu] College of Computer Science and Technology, Hengyang Normal University, Hengyang 421010, China
[Xiaoyu Yang; Lei Wang] Big Data Innovation and Entrepreneurship Education Center of Hunan Province, Changsha University, Changsha 410022, China.
[Liu Fan] College of Computer Science and Technology, Hengyang Normal University, Hengyang 421010, China<&wdkj&>Big Data Innovation and Entrepreneurship Education Center of Hunan Province, Changsha University, Changsha 410022, China.
语种:
英文
关键词:
microbe-drug association;microbe-disease-drug association;Structure-Aware Transformer;Deep Neural Network;STNMDA;lab
期刊:
CURRENT BIOINFORMATICS
ISSN:
1574-8936
年:
2024
卷:
19
期:
10
页码:
919-932
机构署名:
本校为第一机构
院系归属:
计算机科学与技术学院
摘要:
Introduction: Microbes are intimately involved in the physiological and pathological processes of numerous diseases. There is a critical need for new drugs to combat microbe-induced diseases in clinical settings. Predicting potential microbe-drug associations is, therefore, essential for both disease treatment and novel drug discovery. However, it is costly and time-consuming to verify these relationships through traditional wet lab approaches. Methods: We proposed an efficient computational model, STNMDA, that integrated a StructureAware Tr...

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