A specific HeLa cell-labelled and lysosome-targeted upconversion fluorescent probe: PEG-modified Sr2YbF7:Tm3+

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成果类型：

期刊论文

作者：

Xiang, Li-Jun;Zhang, Hui-Hui;Li, Hong;Kong, Lin*;Zhou, Hong-Ping;...

通讯作者：

Kong, Lin

作者机构：

[Tian, Yu-Peng; Li, Hong; Wu, Jie-Ying; Zhang, Hui-Hui; Kong, Lin; Zhou, Hong-Ping; Zhang, Jie; Xiang, Li-Jun] Anhui Univ, Coll Chem & Chem Engn, Hefei 230601, Anhui, Peoples R China.

[Tian, Yu-Peng; Li, Hong; Wu, Jie-Ying; Zhang, Hui-Hui; Kong, Lin; Zhou, Hong-Ping; Zhang, Jie; Xiang, Li-Jun] Anhui Prov Key Lab Chem Inorgan Organ Hybrid Func, Hefei 230601, Anhui, Peoples R China.

[Mao, Yi-Fu] Hengyang Normal Univ, Dept Phys, Hengyang 421001, Peoples R China.

通讯机构：

[Kong, Lin] A

Anhui Univ, Coll Chem & Chem Engn, Hefei 230601, Anhui, Peoples R China.

Anhui Prov Key Lab Chem Inorgan Organ Hybrid Func, Hefei 230601, Anhui, Peoples R China.

语种：

英文

期刊：

Nanoscale

ISSN：

2040-3364

年：

2017

卷：

期：

页码：

18861-18866

DOI：

10.1039/c7nr07093d

基金类别：

General Program of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51772002, 51472002, 51432001]; Science and Technology Plan of Anhui Province [1604b0602016]; Higher Education Revitalization Plan Talent Project of Anhui Province; Undergraduate Training Program for Innovation and Entrepreneurship of Anhui University [201610357007]; Undergraduate Training Program for Scientific Research of Anhui University [KYXL2016027]

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本校为其他机构

院系归属：

物理与电子工程学院

摘要：

In this study, water-soluble PEG-modified Sr2YbF7:Tm3+was prepared conveniently by a one-pot solvothermal method, where the molar ratio of Sr2+to Yb3+was controlled between 3:2 and 1:1. The optimum red-light emission at 677-699 nm was modulated via 0.7% Tm3+doped under irradiation at 980 nm. Interestingly, biological experimental results showed that the PEG-modified Sr2YbF7:Tm3+with low toxicity, excellent cell membrane permeability and high photostability can not only distinguish HeLa cells from mouse embryonic fibroblasts but also target the subcellular organelle lysosome in HeLa cells;there...

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A specific HeLa cell-labelled and lysosome-targeted upconversion fluorescent probe: PEG-modified Sr2YbF7:Tm3+

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