期刊论文

Liu, JB;Fu, D;Ma, YS

英文

Journal of Advanced Research

2090-1232

2023

54

133-146

10.1016/j.jare.2023.01.010

This study was supported partly by grants from the National Natural Science Foundation of China ( 81772932 and 81972214 ), Natural Science Foundation of Hunan Province ( 2021JJ30060 ); Key Research and Development Program of Hunan Province ( 2021NK2026 ), Key Program of Hunan Provincial Department of Science and Technology ( 2020WK2020 ), Shanghai Committee of Science and Technology ( 21140903500 ), Shanghai Natural Science Foundation ( 20ZR1472400 ), Construction of Clinical Medical Centre for Tumor Biological Samples in Nantong ( HS2016004 ), Science and Technology Project of Nantong ( JC2018010 ) and the Jiangsu Provincial University Natural Science Funding ( 19KJB180021 ). This study was supported partly by grants from the National Natural Science Foundation of China (81772932 and 81972214), Natural Science Foundation of Hunan Province (2021JJ30060); Key Research and Development Program of Hunan Province (2021NK2026), Key Program of Hunan Provincial Department of Science and Technology (2020WK2020), Shanghai Committee of Science and Technology (21140903500), Shanghai Natural Science Foundation (20ZR1472400), Construction of Clinical Medical Centre for Tumor Biological Samples in Nantong (HS2016004), Science and Technology Project of Nantong (JC2018010) and the Jiangsu Provincial University Natural Science Funding (19KJB180021). We would like to thank the Laboratory Animal Center of Tongji University (Shanghai, China) for providing the animal experimental platform.

本校为其他机构

Background: Aberrations in MYC underlie a large proportion of liver hepatocellular carcinoma (LIHC) cases; however, MYC is difficult to target because of its undruggable structure. We aimed to uncover MYC-associated molecular targets to provide new strategies for LIHC treatment. Methods: LIHC transcriptome datasets and clinical information were obtained from The Cancer Genome Atlas. A series of bioinformatics analyses were performed for 370 patients who were stratified based on the median MYC expression level (high-MYC group and low-MYC group). Correlation analysis was performed to determine r...