Identification and validation of functional roles for three MYC-associated genes in hepatocellular carcinoma

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成果类型：

期刊论文

作者：

Li, Sha;Xue, Pei;Diao, Xun;Fan, Qi-Yu;Ye, Kun;...

通讯作者：

Liu, JB;Fu, D;Ma, YS

作者机构：

[Diao, Xun; Liu, Ji-Bin; Liu, JB; Li, Sha; Fan, Qi-Yu] Nantong Univ, Inst Oncol, Affiliated Tumor Hosp, Nantong 226631, Jiangsu, Peoples R China.

[Li, Sha] Cent South Univ, Hunan Canc Hosp, Dept Head & Neck Surg, Cent Lab, Changsha 410013, Hunan, Peoples R China.

[Li, Sha] Cent South Univ, Xiangya Sch Med, Affiliated Canc Hosp, Changsha 410013, Hunan, Peoples R China.

[Xue, Pei] Shanghai Jiao Tong Univ, Sch Med, Dept Gen Surg, Div Gastrointestinal & Colorectal Surg,Ruijin Hosp, Shanghai 200025, Peoples R China.

[Ye, Kun] Cent South Univ, Xiangya Hosp 2, Dept Urol, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Liu, JB ] N

[Fu, D ; Ma, YS ] S

Nantong Univ, Inst Oncol, Affiliated Tumor Hosp, Nantong 226631, Jiangsu, Peoples R China.

Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Gen Surg,Inst Pancreat Dis, Shanghai 200025, Peoples R China.

Shanghai Univ Tradit Chinese Med, Longhua Hosp, Canc Inst, Shanghai 200032, Peoples R China.

语种：

英文

关键词：

LIHC;Tumor;Treatment;Biomarker;Therapy

期刊：

Journal of Advanced Research

ISSN：

2090-1232

年：

2023

卷：

页码：

133-146

DOI：

10.1016/j.jare.2023.01.010

基金类别：

National Natural Science Foundation of China [81772932, 81972214]; Natural Science Foundation of Hunan Province [2021JJ30060]; Key Research and Development Program of Hunan Province [2021NK2026]; Key Program of Hunan Provincial Department of Science and Technology [2020WK2020]; Shanghai Committee of Science and Technology [21140903500]; Shanghai Natural Science Foundation [20ZR1472400]; Construction of Clinical Medical Centre for Tumor Biological Samples in Nantong [HS2016004]; Science and Technology Project of Nantong [JC2018010]; Jiangsu Provincial University Natural Science Funding [19KJB180021]

机构署名：

本校为其他机构

院系归属：

生命科学与环境学院

摘要：

Background: Aberrations in MYC underlie a large proportion of liver hepatocellular carcinoma (LIHC) cases; however, MYC is difficult to target because of its undruggable structure. We aimed to uncover MYC-associated molecular targets to provide new strategies for LIHC treatment. Methods: LIHC transcriptome datasets and clinical information were obtained from The Cancer Genome Atlas. A series of bioinformatics analyses were performed for 370 patients who were stratified based on the median MYC expression level (high-MYC group and low-MYC group). Correlation analysis was performed to determine r...

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Identification and validation of functional roles for three MYC-associated genes in hepatocellular carcinoma

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