[Tang, Siping; Gu, Biao; He, Shihui] Hengyang Normal Univ, Coll Chem & Mat Sci, Coll Hunan Prov, Key Lab Funct Organometall Mat, Hengyang 421008, Peoples R China.
[Li, Haitao; Wu, Cuiyan] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ, Changsha 410081, Peoples R China.
[Shen, Youming; Zhang, Chunxiang] Hunan Univ Arts & Sci, Coll Chem & Mat Engn, Hunan Prov Key Lab Water Treatment Funct Mat, Changde 415000, Peoples R China.
通讯机构：
[Siping Tang; Haitao Li] K
[Youming Shen] H
Hunan Provincial Key Laboratory of Water Treatment Functional Materials, College of Chemistry and Materials Engineering, Hunan University of Arts and Science, Changde 415000, PR China<&wdkj&>Key Laboratory of Functional Organometallic Materials of College of Hunan Province, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang 421008, PR China<&wdkj&>Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China
语种：
英文
关键词：
Fast response;Fluorescent probe;Imaging;Lysosome-targetable;Peroxynitrite
期刊：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21907026, 21977028]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [18B369, 20A338]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ50009]; Discipline Group Construction Project of Hengyang Normal University [18XKQ07]; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University [GN18K03]; Guiding science and technology project of Changde City [2020ZD28]; Scientific research project of Hunan University of Arts and Science [20YB23]
机构署名：
本校为第一机构
院系归属：
化学与材料科学学院
摘要：
Peroxynitrite (ONOO-) plays important roles in many pathophysiological processes and its subcellular detection draws increasing attention. In this study, we designed and prepared a novel lysosometargetable fluorescent probe (E)-2-(benzo[d]thiazol-2-yl)-4-methyl-6-((morpholinoimino)methyl)phe nol (BMP) for selective detection of ONOO- in living systems by incorporating a reactive morpholino hydrazone as new ONOO- response site into a benzothiazole derivative as fluorophore. After reaction with ONOO-, an obvious fluorescence increase (83-fold) was observed accompanied with distinct dual colorime...
