Molecular diversification of antimicrobial peptides from the wolf spider Lycosa sinensis venom based on peptidomic, transcriptomic, and bioinformatic analyses

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成果类型：

期刊论文

作者：

Tang, Xing*;Yang, Jing;Duan, Zhigui;Jiang, Liping;Liu, Zhonghua;...

通讯作者：

Tang, Xing

作者机构：

[Tang, Xing] Hengyang Normal Univ, Human Key Lab Conservat & Utilizat Biol Resources, Hengyang 421008, Peoples R China.

[Tang, Xing] Hengyang Normal Univ, Coll Life Sci & Environm, Hengyang 421008, Peoples R China.

[Tang, Xing] East China Univ Technol, Jiangxi Key Lab Mass Spectrometry & Instrumentat, Nanchang 330013, Jiangxi, Peoples R China.

[Yang, Jing] Cent South Univ, Canc Res Inst, Key Lab Carcinogenesis & Canc Invas, Minist Educ China, Changsha 410078, Peoples R China.

[Yang, Jing] Cent South Univ, Sch Basic Med Sci, Changsha 410078, Peoples R China.

通讯机构：

[Tang, Xing] H

[Tang, Xing] E

Hengyang Normal Univ, Human Key Lab Conservat & Utilizat Biol Resources, Hengyang 421008, Peoples R China.

Hengyang Normal Univ, Coll Life Sci & Environm, Hengyang 421008, Peoples R China.

East China Univ Technol, Jiangxi Key Lab Mass Spectrometry & Instrumentat, Nanchang 330013, Jiangxi, Peoples R China.

语种：

英文

关键词：

antimicrobial peptide;top-down sequencing;cDNA library construction;biology database;molecular diversification

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2020

卷：

期：

页码：

1274-1280

DOI：

10.1093/abbs/gmaa107

基金类别：

This work was supported by the grants from the National Natural Science Foundation of China (Nos. 31201718 and 31402025), the Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China (No. IRT13054), the Natural Science Foundation of Jiangxi, China (Nos. 20114BAB214015 and 20142BAB204011), the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province (No. 20134486), the Doctoral Scientific Research Foundation of Hengyang Normal University (No. 18D16), and Open fund project of Hunan Key Laboratory for Conservation and Utilization of Biological Resources in the Nanyue Mountainous Region (No. NY20K05).

机构署名：

本校为第一且通讯机构

院系归属：

生命科学与环境学院

摘要：

The venom of Lycosoidea spiders is a complex multicomponent mixture of neurotoxic peptides (main components) and antimicrobial peptides (AMPs) as minor components. In this study, we described the high-throughput identification and analysis of AMPs from Lycosa sinensis venom (named LS-AMPs) using a combination strategy that includes the following three different analysis approaches: (i) peptidomic analysis, namely reversed-phase high-performance liquid chromatography (RP-HPLC) separation plus top-down sequencing by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MS...

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Molecular diversification of antimicrobial peptides from the wolf spider Lycosa sinensis venom based on peptidomic, transcriptomic, and bioinformatic analyses

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