Objective: To explore the regulative effect of perceived social support between personality and mental health. Methods: With Perceived Social Support Scale, NEO Five Factor Inventory and General Health Questionnaire- GHQ 20, 1800 college students from 9 Hunan colleges and universities were inverstigated. Results: ①Siguificant positive correlation existed between the factors of GHQ-20 and NEO-N, while significant negative correlation between the factors of GHQ-20 and NEO-E,NEO-C and all factors of perceived social support; perceived social s...