会议论文

Association of Clock Gene rs11133391 Polymorphism with Depressions and Primary Insomnia

中文

中国临床心理学杂志

Chinese Journal of Clinical Psychology

1005-3611

2015

23

5

836-838

10.16128/j.cnki.1005-3611.2015.05.018

2014年国家社科基金教育学项目“大学生抑郁症的易感性:社会心理因素与基因多态性的共同作用”(BBA140047)； 2014年湖南省教育厅科研重点项目资助(项目号:14A063)；

本校为其他机构

目的:对clock基因的rs11133391多态性位点进行分析并探讨其与抑郁症患者、原发性失眠患者的关系。方法:采用美国ABI公司的小测序SNP分型技术对155例重性抑郁症患者、105例原发性失眠患者和150名正常对照进行clock基因rS11133391位点分型,对clock基因的rS11133391的基因型和等位基因的频率进行比较。结果:抑郁症患者、原发性失眠患者与正常对照之间clock基因rs11133391多态性的等位基因与基因型没有显著差异(P> 0.05);与对照组相比,原发性失眠患者rs11133391多态性的等位基因频率有显著差异(P

Objective： To explore the association of clock gene with depression and Primary insomnia. Methods： The clock gene rs11133391 was genotyped by Snapshot SNP technique in 155 patients with major depression, 105 patients with Primary insomnia and 150 healthy controls. We compared the genotype and allele gene frequency in three groups. Results：There were no significant differences in genotype and allele gene in clock gene rs11133391 between depression patients and healthy controls（P〈0.05）; There were significant differences in allele gene in c...