Anti-Toxoplasma gondii Effects of a Novel Spider Peptide XYP1 In Vitro and In Vivo

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成果类型：

期刊论文

作者：

Liu, Yuan;Tang, Yaqin;Tang, Xing;Wu, Mengqi;Hou, Shengjie;...

通讯作者：

Jiang, L.

作者机构：

[Liu, Yuan; Tang, Yaqin; Wu, Mengqi; Liu, Xiaohua; Huang, Shuaiqin; Hou, Shengjie; Li, Jing; Jiang, Liping] Cent South Univ, Xiangya Sch Med, Dept Parasitol, Changsha 410013, Peoples R China.

[Tang, Xing] Hengyang Normal Univ, Hunan Key Lab Conservat & Utilizat Biol Resources, Hengyang 421008, Peoples R China.

[Deng, Meichun] Cent South Univ, Sch Life Sci, Dept Biochem & Mol Biol, Changsha 410013, Peoples R China.

[Jiang, Liping] Cent South Univ, China Africa Res Ctr Infect Dis, Xiangya Sch Med, Changsha 410013, Peoples R China.

通讯机构：

[Jiang, L.] D

Department of Parasitology, China

语种：

英文

关键词：

Anti-parasitic activity;Drug discovery;Functional mechanism;Spider peptide XYP1;Toxoplasma gondii

期刊：

Biomedicines

ISSN：

2227-9059

年：

2021

卷：

期：

页码：

934

DOI：

10.3390/biomedicines9080934

基金类别：

Funding: This work was supported by Natural Science Foundation of Hunan Province (grant number 2020JJ4765); Open-End Fund for the Valuable and Precision Instruments of Central South University (grant number CSUZC2019046) and the Doctoral Scientific Research Foundation of Hengyang Normal University (grant number 18D16).

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摘要：

Toxoplasmosis, caused by an obligate intracellular parasite Toxoplasma gondii, is one of the most prevalent zoonoses worldwide. Treatments for this disease by traditional drugs have shown numerous side effects, thus effective alternative anti-Toxoplasma strategies or drugs are urgently needed. In this study, a novel spider peptide, XYP1, was identified from the cDNA library of the venom gland of the spider Lycosa coelestis. Our results showed that XYP1 has potent anti-Toxoplasma activity in vitro and in vivo. Specifically, treatment with XYP1 s...

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Anti-Toxoplasma gondii Effects of a Novel Spider Peptide XYP1 In Vitro and In Vivo

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