期刊论文

Microwave-assisted self-assembly synthesis of organotin complexes and biological activities

中文

中国科学：化学

1674-7224

2019

49

8

1083-1093

10.1360/SSC-2019-0023

湖南省自然科学基金(编号:2017JJ3003) 湖南省教育厅重点科研基金(编号:16A029) 衡阳师范学院学科群建设基金(编号:18XKQ01)资助项目.

本校为第一机构

利用微波“一锅法”合成了4个有机锡配合物(C1~C4),通过红外光谱(IR)、紫外可见吸收光谱(Vis- UV)、~1H NMR、~(13)C NMR、~(119)Sn NMR、高分辨率质谱(HRMS)、X射线单晶衍射以及热重分析等表征了配合物的结构.结构分析表明,配合物C1~C4均为中心对称的平面Sn_2O_2四元环结构.通过MTT法,测试了配合物C1~C4对癌细胞NCI-H460、HepG2、MCF7以及正常人体肝细胞HL7702的体外抑制活性,结果显示,配合物C1对3种癌细胞的抑制活性优于其他配合物及卡铂,有望成为金属有机抗癌药物候选化合物.通过紫外光谱、荧光光谱、黏度、分子对接实验,证实了配合物C1与DNA的相互作用是插入结合方式.

Four organotin complexes (C1–C4) were synthesized by microwave and characterized by elemental analysis, IR, Vis-UV, ~1H NMR, ~(13)C NMR, ~(119)Sn NMR, HRMS, X-ray single crystal diffraction, and thermogravimetric analysis. The structural analysis showed that complexes C1–C4 are centrosymmetric dimer structure with a four-membered central endo-cyclic Sn_2O_2 unit. The inhibitory activities of C1–C4 aganist cancer cells (NCI-H460, HepG2, MCF7) and normal human liver cell (HL7702) were tested by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tet...