期刊论文

Zhu, Yaocan;Wang, Lei

英文

FRONTIERS IN AGING NEUROSCIENCE

1663-4365

2022

13

799500

10.3389/fnagi.2021.799500

This research is partly sponsored by the Research Foundation of Education Bureau of Hunan Province (No. 20B080), the Natural Science Foundation of Hunan Province (No. 2019JJ70010), the Hunan Provincial Natural Science Foundation of China (2020JJ4152), the Science and Technology Plan Project of Hunan Province (2016TP1020), the Hunan Province Science and Technology Project Funds (2018TP1036), and the National Scientific Research Foundation of Hunan Province Education Commission (18B367).

本校为第一机构

Growing evidence have demonstrated that many biological processes are inseparable from the participation of key proteins. In this paper, a novel iterative method called linear neighborhood similarity-based protein multifeatures fusion (LNSPF) is proposed to identify potential key proteins based on multifeature fusion. In LNSPF, an original protein-protein interaction (PPI) network will be constructed first based on known protein-protein interaction data downloaded from benchmark databases, based on which, topological features will be further extracted. Next, gene expression data of proteins wi...