期刊论文

Syntheses, Crystal Structures and Biological Activity of 2-Oxo-3-phenylpropionic Acid Aroyl Hydrazone Di-2,4-dichlorobenzyltin Complexes

Kuang Dai-Zhi

中文

无机化学学报

1001-4861

2016

32

8

1383-1390

10.11862/CJIC.2016.179

No.2015JC3060:湖南省科技计划 No.14K014:湖南省教育厅项目 15C0199:湖南省教育厅项目 15C0200:湖南省教育厅项目 No.15A02:衡阳师范学院科学基金

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二(2,4-二氯苄基)二氯化锡分别与2-羰基-3-苯基丙酸苯甲酰腙及2-羰基-3-苯基丙酸水杨酰腙反应,合成了2个取代苄基锡配合物(C1、C2),通过元素分析、IR、~1H NMR、~(13)C NMR、~(119)Sn NMR、X射线单晶衍射以及热重分析等表征了配合物结构。测试了配合物对癌细胞Hela、MCF7、HepG2、Colo205、NCI-H460以及正常人体胚肾细胞HEK293、正常人体肝细胞HL7702的体外抑制活性;在Tris-HCl缓冲溶液中,以EB做为荧光探针,用荧光光谱法初步研究了配合物与小牛胸腺DNA的相互作用。结果表明:配合物C1、C2对5种癌细胞都有明显的抑制作用,配合物C2对HEK293、HL7702的细胞毒性远小于C1;配合物C1与小牛胸腺DNA作用是...

Two substituted benzyltin complexes has been synthesized via the reaction of 2-oxo-3-phenylpropionic acid aroyl hydrazone with di-2,4-dichlorobenzyltin dichloride. The complexes Cl and C2 have been characterized by IR, UV-Vis,1H NMR,13C NMR119Sn NMR spectra, elemental analysis and the crystal structures have been determined by X-ray diffraction. In vitro antitumor activities of both complexes were evaluated by 3-(4,5- dimethylthiazoly-2-yl)- 2,+- diphenyltetrazolium bromide (MTT) assay against five human cancer cell lines (Hela, MCF7, HepG2, Co...