期刊论文

Microwave-Solvothermal Syntheses, Crystal Structures and in Vitro Antitumor Activities of Two Bis[oxo-bis(aromatic carboxylato dibutyltin)]

Kuang Dai-Zhi

中文

无机化学学报

1001-4861

2017

33

4

589-594

10.11862/CJIC.2017.071

湖南省高校创新平台开放基金（No.16K011,14K014）； 湖南省自然科学基金（No.13JJ3112）资助项目；

本校为第一且通讯机构

在微波甲醇溶剂热中,二丁基氧化锡分别与4-叔丁基苯甲酸和3-甲基-4-氨基苯甲酸反应,合成了具有桥联的有机锡化合物[(μ_3-O)(n-Bu_2Sn)_2(O_2CR)_2]_2(R=4-(t-Bu)-C_6H_5 (1),(3-Me-4-NH_2)-C_6H_4 (2)),并对它们的组成和结构进行了表征,X射线晶体衍射表明,化合物1、2的中心具有Sn_2O_2四元环平面结构,锡与配基原子构成畸形三角双锥六面体。人体外抗肿瘤活性的初步研究表明,化合物1、2对人结肠癌(HT-29)、肝癌细胞(HepG2)、乳腺癌(MCF-7)、鼻咽癌(KB)和肺癌细胞(A549)均显示出比临床使用的顺铂还强的抗癌活性。

Two di-n-butyltin compounds with μ3-O bridging the framework, [(μ3-O)(n-Bu2Sn)2(O2CR)2]2(R=4-(t-Bu)-C6H5 (1), (3-Me-4-NH2)-C6H4 (2)), were obtained by microwave-assisted solvothermal reaction of di-n-butyltin oxide precursor with the aromatic acid in methanol environments, which have been structurally characterized by elemental analysis, IR and NMR (1H,13C and119Sn) spectra and X-ray crystallography diffraction analyses. This compound was of a centrosymmetric dimer structure mode with a four-membered central endo-cyclic Sn2O2 unit in which th...