期刊论文

Two Di-n-butyltin Carboxylates with a Sn_4O_4 Ladder-like Framework: Microwave Solvothermal Syntheses,Structures and in Vitro Antitumor Activities

Kuang Dai-Zhi

中文

无机化学学报

1001-4861

2017

33

5

830-836

10.11862/CJIC.2017.107

No.16K011:湖南省高等学校创新平台开放基金 14K014:湖南省高等学校创新平台开放基金 No.13JJ3112:湖南省自然科学基金

本校为第一且通讯机构

在甲醇微波溶剂热中,二丁基氧化锡分别与4-甲基苯甲酸、4-二甲氨基苯甲酸反应,合成了2个具有梯形结构的二丁基锡羧酸酯[(μ_3-O)(μ_2-OMe)(n-Bu_2Sn)_2(O_2CR)]_2 (R=4-Me-C_6H_4 (1),4-Me_2N-C_6H_4 (2)),并对其进行了元素分析、IR和(~1H,~(13)C和 ~(119)Sn) NMR光谱表征。X射线晶体衍射分析表明,化合物1、2具有Sn_4O_4构筑的3个四元环梯形骨架平面结构,μ_3-O桥联2个环内梯锡和1个环梯端锡原子,此外,甲醇氧还以μ_2-O桥联1个环内梯锡和1个环梯端锡原子,锡与配基原子构成畸形三角双锥六面体。化合物对人结肠癌(HT-29)、肝癌细胞(HepG2)、乳腺癌(MCF-7)、鼻咽癌(KB)和肺癌细胞(A549)均显示出比...

Two di-n-butyltin carboxylates with a Sn4O4 ladder-like framework, [(μ3-O)(μ2-OMe)(n-Bu2Sn)2(O2CR)]2 (R=4-methylphenyl (1), 4-(dimethylamino) phenyl (2)), were obtained by the microwave-assisted solvothermal reaction of di-n-butyltin oxide precursor with the 4-methylbenzoic acid, 4-dimethylaminobenzoic acid in methanol environments, respectively. The compounds were characterized by elemental analysis, IR, (1H,13C and119Sn) NMR spectra and X-ray crystallography diffraction analyses. The compounds have similar structures containing a Sn4O4 ladd...