期刊论文

Syntheses,Structures and in Vitro Antitumor Activity of Bis(tricyclohexyltin) Pyridinedicarboxylate with Macrocyclic Supramolecular Structure

Kuang Dai-Zhi

中文

无机化学学报

1001-4861

2018

34

6

1035-1042

10.11862/CJIC.2018.111

湖南省高校创新平台开放基金（No.16K011） 功能金属有机材料湖南省普通高校重点实验室开放基金（No.GN16K01） 湖南省自然科学基金（No.13JJ3112）资助项目

本校为第一且通讯机构

在微波溶剂热中,三环己基氢氧化锡分别与2,6-H_2pydc和3,5-H_2pydc(H_2pydc=吡啶二甲酸)反应,合成了4个二(三环己基锡)吡啶-二甲酸酯:{[(2,6-Hpydc)SnCy_3]·MeOH}_n (1)、[(2,6-pydc)Sn_2Cy_6(H_2O)]·PhH (2)、[(3,5-pydc)Sn_2Cy_6(MeOH)]·MeOH (3)和[(3,5-pydc)Sn_2Cy_6(H_2O)]·EtOH (4)。对它们的组成和结构进行了元素分析、IR、(~1H,~(13)C和~(119)Sn)NMR和单晶X射线衍射表征。化合物中心锡与配基原子构成畸形四、六面体构型,由于氢键作用,化合物形成二维大环网状超分子结构。初步探索了1、3对人结肠癌(HT-29)、肝癌细胞(HepG2)、乳腺癌(MCF-7)、鼻咽癌(KB)和肺癌细胞(A549)的增殖抑制活...

Four bis (tricyclohexyltin)pyridinedicarboxylates, {[(2,6-Hpydc)SnCy3]center dot MeOH}(n) (1), [(2,6-pydc)Sn2Cy6(H2O)]center dot PhH (2), [(3,5-pydc)Sn2Cy6(MeOH)]center dot MeOH (3) and [(3,5-pydc)Sn2Cy6(H2O)]center dot EtOH (4), have been prepared by the microwave-assisted solvothermal reaction of tricyclohexyltin hydroxide with 2,6-H(2)pydc and 3,5-H(2)pydc (H(2)pydc=pyridinedicarboxylic acid), respectively. Compounds 1 similar to 4 have been characterized by elemental, IR, (H-1, C-13 and Sn-119) NMR and single crystal X-ray diffraction analyses. The distorted tetrahedral and trigonal bipyra...