期刊论文

Syntheses, Crystal Structures and in Vitro Antitumor Activity of Three Bis(organotin) Pyridine-2,3(5)-dicarboxylate

Kuang Dai-Zhi

中文

无机化学学报

1001-4861

2018

34

1

99-104

10.11862/CJIC.2018.002

No.16K011:湖南省高等学校创新平台开放基金 14K014:湖南省高等学校创新平台开放基金 No.13JJ3112:湖南省自然科学基金

本校为第一且通讯机构

在微波溶剂热中,三环已基氢氧化锡、氧化双(三((2-甲基-2-苯基)丙基)锡)与吡啶-2,3(5)-二甲酸反应,合成了3个双核二(有机锡)吡啶-2,3(5)-二甲酸酯:Py(CO)_2(SnR_3)_2(MeOH)_n(R:Cy,n=1(1),2(2);R:PhCMe_2CH_2,n=0(3)),对它们的组成和结构进行了元素分析、IR、(~1H,~(13)C,~(119)Sn)NMR和X射线晶体衍射分析表征,化合物中心锡与配基原子构成畸形四/六面体构型,由于氢键作用,化合物1形成一维链,2形成二维34元大环网状结构.化合物对人结肠癌(HT-29)、肝癌细胞(HepG2)、乳腺癌(MCF-7)、鼻咽癌(KB)和肺癌细胞(A549)的增殖有较强的抑制作用.

Three dinuclear bis(organotin) pyridine-2, 3(5)-dicarboxylate, Py(CO)2(SnR3)2(MeOH)n (R:Cy, n=1 (1), 2 (2); R:PhCMe2CH2, n=0 (3)), have been prepared by the microwave-assisted solvothermal reaction of tricyclohexyltin hydroxide, bis(tri(2-methyl-2-phenyl)propyl)tin oxide with the pyridine-2, 3(5)-dicarboxylic acid, respectively. The compounds are characterized by elemental analysis, IR, (1H,13C,119Sn) NMR spectra and X-ray crystallography diffraction analyses. The distorted tetrahedral and trigonal bipyramid geometry is formed by the tin and li...