期刊论文

Syntheses, Crystal Structures and Biological Activity of Dibenzyltin Complexes Based on Substituted Benzoyl Hydrazine-Pyruvic Acid

Jiang Wu-Jiu

中文

无机化学学报

1001-4861

2019

35

7

1212-1220

10.11862/CJIC.2019.151

湖南省大学生研究性学习和创新性实验计划项目(No.cx1813) 湖南省自然科学基金(No.2017JJ3003) 衡阳师范学院学科群项目(No.18XKQ01)资助.

本校为第一且通讯机构

二苄基二氯化锡分别与对甲氧基苯甲酰肼缩丙酮酸及对硝基苯甲酰肼缩丙酮酸反应,合成了2个二苄基锡配合物(C1、 C2),通过元素分析、IR、~1H NMR、~(13)C NMR、~(119)Sn NMR、HRMS以及X射线单晶衍射等表征了配合物结构.测试了配合物C1、C2的热稳定性以及配合物对癌细胞H460、HepG2、MCF7的体外抑制活性;在Tris-HCl缓冲溶液中,以EB做为荧光探针,用荧光光谱法初步研究了配合物C1与小牛胸腺DNA的相互作用;并且用凝胶电泳法研究了配合物C1切割质粒DNA pBR322的能力.结果表明:配合物C1、C2对3种癌细胞都有较好的抑制作用,但是C1更优于C2;配合物C1与小牛胸腺DNA作用是插入结合作用所致,能有效的将超螺旋...

Two benzyltin complexes has been synthesized via the reaction of substituted benzoyl hydrazine-pyruvic acid with dibenzyltin dichloride. The complexes C1 and C2 have been characterized by IR, 1H NMR, 13C NMR 119Sn NMR spectra, elemental analysis, HRMS and the crystal structures have been determined by X-ray diffraction. Crystallographic data show that C1 forms a one-dimensional chain structure, C2 is a centrosymmetric dimer, and there is a Sn2O2 four-membered ring in the middle of the molecule. In vitro antitumor activities of both complexes we...