期刊论文

Syntheses, Crystal Structures and in Vitro Antitumor Activity of Two Organotin Hydroxybenzoate

Zhang Fu-Xing

中文

无机化学学报

1001-4861

2019

35

4

598-604

10.11862/CJIC.2019.083

湖南省高校创新平台开放基金项目(No.GN16K01) 衡阳市科技计划(No.2016KJ03) 湖南省重点学科基金 湖南省高校科技创新团队支持计划 湖南省大学生研究性学习和创新性实验项目资助.

本校为第一且通讯机构

合成了2个有机锡羟基苯甲酸酯配合物:梯形结构的二(对氯苄基)锡邻羟基苯甲酸酯[(μ_3-O)(μ_2-OH)(p-Cl~-C_6H_4CH_2Sn)_2 (O_2CC_6H_4-OH-o)]_2 (1)和三苯基锡二(对羟基苯甲酸)酯(2)。通过元素分析、红外光谱、差热分析、X射线单晶衍射等方法对配合物进行了结构表征,并对其进行了量子化学从头计算和体外抗癌活性研究。结果显示:配合物1为具有Sn_2O_2构筑的3个平面四元环组成的梯形骨架结构,配合物2为单锡核结构,锡原子均为五配位的畸变三角双锥构型;配合物对人结肠癌细胞(HT-29)、肝癌细胞(HepG2)、乳腺癌细胞(MCF-7)、宫颈癌细胞(Hela)和肺癌细胞(A549)均显示出比临床使用的顺铂更强的抗癌活性...

Di(p-chlorobenzy)tin 2-hydroxybenzoate with ladder-like framework [(mu(3)-0)(mu(2)-OH)(p-C1-C6H4CH2Sn)(2) (02CC6H4-0H-o)]2 (1) and triphenyltin 4-hydroxybenzoate (2) have been synthesized. The complexes were characterized by elemental analysis, IR spectroscopy, thermogravimetric analysis and single-crystal X-ray diffraction. Quantum chemical ab initio calculation as well as in vitro anticancer activity test have been carried out for the complexes. The results showed that complex 1 forms a structure containing Sn2O2 ladder-like skeleton and the complex 2 forms a nuclear tin structure. The tin a...