期刊论文

Syntheses, Antitumor Activity and DNA Interaction of Diphenyltin Complexes Based on Salen-like Ligand

Jiang Wu-Jiu

中文

无机化学学报

1001-4861

2021

37

10

1801-1808

10.11862/CJIC.2021.209

湖南省教育厅科研项目（No.19C0279）； “功能金属有机化合物”科技创新团队资助；

本校为第一且通讯机构

利用类salen配体二苯乙二酮苯甲酰腙或二苯乙二酮水杨酰腙与二苯基二氯化锡反应,合成了2个二苯基锡配合物[(C_(6)H_(5)(O)C=N—N=C(Ph)—(Ph)C=N—N=C(O)—C_(6)H_(5))2SnPh2(CH_(3)OH)]·3CH_(3)OH (1)和 [(o-OH—C_(6)H_(4)(O)C=N—N=C(Ph)—(Ph)C=N—N=C(O)—(o-OH—C_(6)H_(4)))2SnPh2(CH_(3)OH)]·CH_(3)OH (2),通过IR、^(1)H NMR、^(13)C NMR、^(119)Sn NMR、元素分析、HRMS 以及X射线单晶衍射等表征了配合物结构。测试了配合物1、2的热稳定性及其对癌细胞的体外抑制活性,发现配合物2对癌细胞NCIH_(4)60、HepG2、MCF7表现出略优的抑制活性。利用紫外可见吸收光谱、荧光猝灭光谱研究了配合...

Two diphenyltin complexes, [(C_6H_5(O)C=N-N=C(Ph)-(Ph)C=N-N=C(O)-C_6H_5)_2SnPh_2(CH_3OH)]· 3CH_3OH (1) and [(o-OH- C_6H_4(O)C=N-N=C(Ph)- (Ph)C=N-N=C(O)- (o-OH- C_6H_4))_2SnPh_2(CH_3OH)]· CH_3OH (2), have been synthesized via the reaction of diphenyl ethylenedione benzoyl hydrazone or diphenylethyl-enedione salicylhydrazone with diphenyltin dichloride. Complexes 1 and 2 have been characterized by IR, ~1H NMR, ~(13)C NMR, ~(119)Sn NMR spectra, elemental analysis, HRMS and the crystal structures have been determined by X-ray diffraction. The the...