期刊论文

Zhang, FX

中文

无机化学学报

1001-4861

2023

39

11

2083-2090

10.11862/CJIC.2023.182

No.2021JJ40010:湖南省自然科学青年基金项目 No.2021HSKFJJ002:湖南省功能金属有机化合物重点实验室开放基金 :湖南省应用特色学科基金 :湖南省高校科技创新团队支持计划 :湖南省及学校大学生创新创业训练计划项目

本校为第一且通讯机构

合成了 2个苯甲羟肟酸有机锡配合物:[(o-Cl-C6H4CH2)2Sn(C6H5CONO)2](1)和[(o-CH3-C6H4CH2)2Sn(C6H5CONO)(C6H5COO)](2).通过元素分析、红外光谱、核磁共振氢谱、热重分析、单晶X射线衍射等方法对配合物进行了结构表征,对其结构进行量子化学从头计算和体外抗癌活性研究.结果显示:配合物均为单锡核结构,配合物1为六配位的畸变八面体构型,配合物2为五配位的畸变三角双锥构型;配合物1对人宫颈癌细胞(HeLa)、肝癌细胞(HuH-7)和肺腺癌细胞(H1975)显示出比临床使用的顺铂强的抑制活性,而配合物2的抑制活性要弱得多.

Two benzohydroxamic acid organotin complexes [(o-Cl-C6H4CH2)(2)Sn(C6H5CONO)(2)] (1) and [(o-CH3-C6H4CH2)(2)Sn(C6H5CONO)(C6H5COO)] (2) were synthesized by solvothermal method using methanol as a solvent. Complexes 1 and 2 were characterized by elemental analysis, IR, H-1 NMR, thermogravimetric analysis, single-crystal X- ray diffraction, etc. The study on the complexes has been performed with quantum chemistry calculation and in vitro anticancer activity. The results show that the two complexes are monotin nuclear structures; complexes 1 and 2 are the six-coordinated distorted octahedron config...