Aim: To study the case of a college student's insomnia with cognitive-comprehensive therapy, so as to analyze the curative effect of the cognitive-comprehensive therapy on insomnia. Methods: The cognitive -comprehensive therapy was applied as the main therapy, supportive therapy and relaxation training were taken as the assistant therapies, a female college student suffered from insomnia was given psychotherapy. Results: Less than 2 months later, the patient's insomnia symptoms were obviously lessened. Follow-up by telephone a month after the treatment, the patient's symptoms significantly tur...