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Detection of mitophagy in live cells with indole derived near-infrared fluorogenic probes

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成果类型:
期刊论文
作者:
Wang, Xuanyuan;Chen, Wen*;Liu, Shuangling;Xu, Yihong;Xiong, Zhimei;...
通讯作者:
Chen, Wen;Zhang, Yuan
作者机构:
[Wang, Xuanyuan; Liu, Mengqin; Xiong, Zhimei; Zhang, Jingting; Sun, Leying; Xu, Yihong; Jiang, Lu; Li, Yingzi; Huang, Leyuan] College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421001, PR China
[Chen, Wen] College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421001, PR China. Electronic address: wenchen@hnu.edu.cn
[Liu, Shuangling] State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 Hunan, PR China
[Zhang, Yuan] College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421001, PR China. Electronic address: zhangyuan1@hnu.edu.cn
通讯机构:
[Chen, Wen; Zhang, Yuan] C
College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421001, PR China. Electronic address:
语种:
英文
关键词:
Dual-targeting;Fluorescence imaging;Mitophagy;Two-channel
期刊:
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
ISSN:
1386-1425
年:
2025
卷:
340
页码:
126368
机构署名:
本校为第一且通讯机构
院系归属:
化学与材料科学学院
摘要:
Mitophagy is an indispensable cellular process that plays a crucial role in regulating mitochondrial quality control and cellular metabolism. Therefore, monitoring the changes in the mitochondrial and lysosomal microenvironment during the mitophagy process is extremely important. However, existing mitophagy probes only target changes in a single indicator (viscosity, pH value, or polarity) within the microenvironment, which may reduce the selectivity and accuracy of assessing mitophagy in complex biological settings. To address this, we have developed a dual-channel detection near-infrared (NI...

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