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Synthesis, anticancer activity, and mechanistic investigations of aryl-alkyl diorganotin arylformylhydrazone complexes

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成果类型:
期刊论文
作者:
Jiang, Wujiu*;Luo, Qing;Huang, Wei;Tan, Yuxing;Peng, Yiyuan
通讯作者:
Jiang, Wujiu;Peng, YY
作者机构:
[Jiang, Wujiu; Peng, Yiyuan] Jiangxi Normal Univ, Coll Chem & Mat, Key Lab Green Chem, Nanchang 330022, Jiangxi, Peoples R China.
[Jiang, Wujiu; Tan, Yuxing; Luo, Qing; Huang, Wei] Hengyang Normal Univ, Coll Hunan Prov, Coll Chem & Mat Sci, Key Lab Funct Met Organ Cpds Hunan Prov,Key Lab Or, Hengyang 421008, Hunan, Peoples R China.
通讯机构:
[Jiang, WJ; Peng, YY ] J
Jiangxi Normal Univ, Coll Chem & Mat, Key Lab Green Chem, Nanchang 330022, Jiangxi, Peoples R China.
语种:
英文
关键词:
Acylhydrazone;Anticancer activity;Anticancer mechanisms;Complex;Methylphenyltin;Synthesis
期刊:
Journal of Inorganic Biochemistry
ISSN:
0162-0134
年:
2025
卷:
262
页码:
112756
基金类别:
CRediT authorship contribution statement Wujiu Jiang: Writing – review & editing, Writing – original draft, Methodology, acquisition, Conceptualization. Qing Luo: Validation, Investigation, Formal analysis. Wei Huang: Validation, Investigation, Formal analysis. Yuxing Tan: Writing – review & editing, Writing – original draft, acquisition. Yiyuan Peng: Writing – review & editing, Writing – original draft, Project administration, acquisition.
机构署名:
本校为其他机构
院系归属:
化学与材料科学学院
摘要:
Diorganotin acylhydrazone complexes with mitochondrial targeting demonstrate significant potential as replacements for platinum-based complexes due to their potent anticancer properties. Twelve methylphenyltin arylformylhydrazone complexes have been synthesized by microwave “one-pot” reaction. The complexes have been characterized by FT-IR, multinuclear NMR (1H, 13C, and 119Sn), TGA, and HRMS. Crystal structures were determined for 10 out of the 12 complexes under study. Structures 1 through 8, 10 and 12 possessed a central symmetric structur...

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