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Synthesis, anticancer activity, and mechanistic investigations of aryl-alkyl diorganotin arylformylhydrazone complexes.

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成果类型:
期刊论文
作者:
Jiang, Wujiu*;Luo, Qing;Huang, Wei;Tan, Yuxing;Peng, Yiyuan*
通讯作者:
Jiang, Wujiu;Peng, Yiyuan
作者机构:
[Jiang, Wujiu] Key Laboratory of Green Chemistry, Jiangxi Province, College of Chemistry and Materials, Jiangxi Normal University, Nanchang, Jiangxi 330022, China
[Jiang, Wujiu] Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, College of Hunan Province, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan 421008, China. Electronic address: jiang59@jxnu.edu.cn
[Tan, Yuxing; Luo, Qing; Huang, Wei] Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, College of Hunan Province, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan 421008, China
[Peng, Yiyuan] Key Laboratory of Green Chemistry, Jiangxi Province, College of Chemistry and Materials, Jiangxi Normal University, Nanchang, Jiangxi 330022, China. Electronic address: yypeng@jxnu.edu.cn
通讯机构:
[Jiang, Wujiu; Peng, Yiyuan] K
Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, College of Hunan Province, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan 421008, China. Electronic address:
Key Laboratory of Green Chemistry, Jiangxi Province, College of Chemistry and Materials, Jiangxi Normal University, Nanchang, Jiangxi 330022, China. Electronic address:
语种:
英文
关键词:
Acylhydrazone;Anticancer activity;Anticancer mechanisms;Complex;Methylphenyltin;Synthesis
期刊:
Journal of Inorganic Biochemistry
ISSN:
0162-0134
年:
2024
卷:
262
页码:
112756
机构署名:
本校为通讯机构
摘要:
Diorganotin acylhydrazone complexes with mitochondrial targeting demonstrate significant potential as replacements for platinum-based complexes due to their potent anticancer properties. Twelve methylphenyltin arylformylhydrazone complexes have been synthesized by microwave "one-pot" reaction. The complexes have been characterized by FT-IR, multinuclear NMR ((1)H, (13)C, and (119)Sn), TGA, and HRMS. Crystal structures were determined for 10 out of the 12 complexes under study. Structures 1 through 8, 10 and 12 possessed a central symmetric stru...

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