Synthesis, anticancer activity, and mechanistic investigations of aryl-alkyl diorganotin arylformylhydrazone complexes

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成果类型：

期刊论文

作者：

Jiang, Wujiu;Luo, Qing;Huang, Wei;Tan, Yuxing;Peng, Yiyuan

通讯作者：

Wujiu Jiang<&wdkj&>Yiyuan Peng

作者机构：

[Jiang, Wujiu] Key Laboratory of Green Chemistry, Jiangxi Province, College of Chemistry and Materials, Jiangxi Normal University, Nanchang, Jiangxi 330022, China

[Jiang, Wujiu] Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, College of Hunan Province, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan 421008, China. Electronic address: jiang59@jxnu.edu.cn

[Tan, Yuxing; Luo, Qing; Huang, Wei] Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, College of Hunan Province, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan 421008, China

[Peng, Yiyuan] Key Laboratory of Green Chemistry, Jiangxi Province, College of Chemistry and Materials, Jiangxi Normal University, Nanchang, Jiangxi 330022, China. Electronic address: yypeng@jxnu.edu.cn

通讯机构：

[Wujiu Jiang; Yiyuan Peng] K

Key Laboratory of Green Chemistry, Jiangxi Province, College of Chemistry and Materials, Jiangxi Normal University, Nanchang, Jiangxi 330022, China<&wdkj&>Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, College of Hunan Province, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan 421008, China<&wdkj&>Key Laboratory of Green Chemistry, Jiangxi Province, College of Chemistry and Materials, Jiangxi Normal University, Nanchang, Jiangxi 330022, China

语种：

英文

关键词：

Acylhydrazone;Anticancer activity;Anticancer mechanisms;Complex;Methylphenyltin;Synthesis

期刊：

Journal of Inorganic Biochemistry

ISSN：

0162-0134

年：

2025

卷：

262

页码：

112756

DOI：

10.1016/j.jinorgbio.2024.112756

基金类别：

CRediT authorship contribution statement Wujiu Jiang: Writing – review & editing, Writing – original draft, Methodology, acquisition, Conceptualization. Qing Luo: Validation, Investigation, Formal analysis. Wei Huang: Validation, Investigation, Formal analysis. Yuxing Tan: Writing – review & editing, Writing – original draft, acquisition. Yiyuan Peng: Writing – review & editing, Writing – original draft, Project administration, acquisition.

机构署名：

本校为通讯机构

院系归属：

化学与材料科学学院

摘要：

Diorganotin acylhydrazone complexes with mitochondrial targeting demonstrate significant potential as replacements for platinum-based complexes due to their potent anticancer properties. Twelve methylphenyltin arylformylhydrazone complexes have been synthesized by microwave “one-pot” reaction. The complexes have been characterized by FT-IR, multinuclear NMR (1H, 13C, and 119Sn), TGA, and HRMS. Crystal structures were determined for 10 out of the 12 complexes under study. Structures 1 through 8, 10 and 12 possessed a central symmetric structur...

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Synthesis, anticancer activity, and mechanistic investigations of aryl-alkyl diorganotin arylformylhydrazone complexes

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