Raman spectroscopy of deuterium-labeled macromolecules: Emerging strategies in biomedical research

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成果类型：

期刊论文

作者：

Zheng, Zefeng;Cui, Ying;Zhang, Boyou;Li, Yang;Liu, Yongjie;...

通讯作者：

Liu, Jing;Wang, LJ;Yuan, F

作者机构：

[Liu, Jing; Wang, Lijia; Li, Yang; Zheng, Zefeng; Liu, Yongjie] Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Natl Childrens Reg Med Ctr,Sch Med, Hangzhou 310052, Peoples R China.

[Liu, Jing; Wang, Lijia; Li, Yang; Zheng, Zefeng; Liu, Yongjie] Zhejiang Key Lab Neonatal Dis, Hangzhou 310052, Peoples R China.

[Cui, Ying] Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Met Organ Cpds Hunan Prov, Hengyang 421001, Peoples R China.

[Zhang, Boyou] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Thorac Surg, Hangzhou 310018, Peoples R China.

[Fan, Shanji] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Breast & Thyroid Surg, Hengyang 421000, Peoples R China.

通讯机构：

[Liu, J; Wang, LJ ; Yuan, F ] Z

Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Natl Childrens Reg Med Ctr,Sch Med, Hangzhou 310052, Peoples R China.

Zhejiang Hosp, Dept Thorac Surg, Hangzhou 310013, Peoples R China.

语种：

英文

关键词：

Deuterium;Macromolecules;Raman spectroscopy

期刊：

International Journal of Biological Macromolecules

ISSN：

0141-8130

年：

2025

卷：

320

期：

Pt 3

页码：

145752

DOI：

10.1016/j.ijbiomac.2025.145752

基金类别：

National Natural Science Foundation of China [82302486]; Zhejiang Provincial Natural Science Foundation of China [LBY22H180013, LBY24H170005]; Hunan Provincial Natural Science Foundation of China [2023JJ50093]; Medical and Health Science and Technology Program of Zhejiang Province [2021RC085]; Traditional Chinese Medicine Science and Technology Project of Zhejiang Province [2024ZF001, 2025ZL160]; Hangzhou West Sci-Tech Corridor Innovation and Development Special Fund for Disciplines; ZJU-Gensci Children's Health Research & Development Center

机构署名：

本校为其他机构

院系归属：

化学与材料科学学院

摘要：

When macromolecules are exposed to deuterium-rich environments, hydrogen atoms on them undergo hydrogen‑deuterium exchange, which induces a characteristic Raman spectral redshift, providing a robust signature for probing intracellular microenvironments. This review is a comprehensively survey of the diverse applications of Raman spectroscopy of deuterium-labeled macromolecules in biomedicine over recent years. We summarize its utility in bacterial resistance and metabolism investigations, and discuss applications spanning cellular to whole-ani...

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Raman spectroscopy of deuterium-labeled macromolecules: Emerging strategies in biomedical research

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