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The power and the promise of synthetic lethality for clinical application in cancer treatment.

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成果类型:
期刊论文
作者:
Liu, Qian-Wen;Yang, Zhi-Wen;Tang, Qing-Hai;Wang, Wen -Er;Chu, Da-Sheng;...
作者机构:
[Liu, Qian-Wen; Yu, Hong; Liu, Xin-Yun; Yang, Qin-Xin] Department of Pathology, The Affiliated Taizhou People's Hospital of Nanjing Medical University,Taizhou,Jiangsu Province 225300,China
[Liu, Qian-Wen] General Surgery, Institute of Pancreatic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine,Shanghai 200025,China
[Yang, Zhi-Wen] Department of Pharmacy, Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai,Shanghai 200050,China
[Tang, Qing-Hai] Hunan Key Laboratory for Conservation and Utilization of Biological Resources in the Nanyue Mountainous Region and College of Life Sciences, Hengyang Normal University,Hengyang,Hunan Province 421008,China
[Wang, Wen -Er] General Surgery, the Fourth Hospital Of Changsha, Changsha Hospital Of Hunan Normal University,Changsha,Hunan Province 410006,China
语种:
英文
关键词:
Cancer;Clinical application;DNA repair;Drug;Synthetic lethality
期刊:
Biomedicine & Pharmacotherapy
ISSN:
0753-3322
年:
2024
卷:
172
页码:
116288
基金类别:
National Natural Science Foundation of China
机构署名:
本校为其他机构
摘要:
Synthetic lethality is a phenomenon wherein the simultaneous deficiency of two or more genes results in cell death, while the deficiency of any individual gene does not lead to cell death. In recent years, synthetic lethality has emerged as a significant topic in the field of targeted cancer therapy, with certain drugs based on this concept exhibiting promising outcomes in clinical trials. Nevertheless, the presence of tumor heterogeneity and the intricate DNA repair mechanisms pose challenges to the effective implementation of synthetic lethality. This review aims to explore the concepts, dev...

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