The power and the promise of synthetic lethality for clinical application in cancer treatment

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成果类型：

期刊论文

作者：

Liu, Qian-Wen;Yang, Zhi-Wen;Tang, Qing-Hai;Wang, Wen -Er;Chu, Da-Sheng;...

通讯作者：

Yu, H;Fu, D;Liu, JB;Xu, XS;Wang, XF;Tao, K

作者机构：

[Liu, Qian-Wen; Yu, Hong; Liu, Xin-Yun; Yang, Qin-Xin] Nanjing Med Univ, Dept Pathol, Affiliated Taizhou Peoples Hosp, Taizhou 225300, Jiangsu, Peoples R China.

[Liu, Qian-Wen; Fu, Da] Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Pancreat Dis, Gen Surg,Sch Med, Shanghai 200025, Peoples R China.

[Yang, Zhi-Wen] East China Normal Univ, Changning Matern & Infant Hlth Hosp, Dept Pharm, Shanghai 200050, Peoples R China.

[Tang, Qing-Hai] Hengyang Normal Univ, Coll Life Sci & Environm, Hunan Key Lab Conservat & Utilizat Biol Resources, Hengyang 421008, Peoples R China.

[Wang, Wen -Er] Hunan Normal Univ, Hosp Changsha 4, Dept Gen Surg, Changsha 410006, Hunan, Peoples R China.

通讯机构：

[Xu, XS ; Fu, D ] S

[Liu, JB ; Yu, H ] N

[Tao, K ] T

[Wang, XF ] F

Nanjing Med Univ, Dept Pathol, Affiliated Taizhou Peoples Hosp, Taizhou 225300, Jiangsu, Peoples R China.

语种：

英文

关键词：

Synthetic lethality;Cancer;Drug;DNA repair;Clinical application

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2024

卷：

172

页码：

116288

DOI：

10.1016/j.biopha.2024.116288

基金类别：

National Natural Science Foundation [81972214, 82373348]; Shanghai Natural Science Foundation [21140903500]; Project Foundation of Taizhou School of Clinical Medicine, Nanjing Medical University [TZKY20220204, TZKY20220205]; Nantong Health Science and Technology Project [MS2022053]; Jiangsu Province Traditional Chinese Medicine Science and Technology Development Program [YB2020067]; Nantong Basic Science and Technology Program [JC22022027]; Project of Hengyang City Science and Technology Innovation [202250045230]; Natural Science Foundation of Hunan Province [2021JJ30060]; Natural Science Foundation of Fujian Province [2022J011427]; Key Project of Scientific Research Program of Hunan Education Department [21A0442]; Nantong University Clinical Medicine Special Project [2022JZ014]

机构署名：

本校为其他机构

院系归属：

生命科学与环境学院

摘要：

Synthetic lethality is a phenomenon wherein the simultaneous deficiency of two or more genes results in cell death, while the deficiency of any individual gene does not lead to cell death. In recent years, synthetic lethality has emerged as a significant topic in the field of targeted cancer therapy, with certain drugs based on this concept exhibiting promising outcomes in clinical trials. Nevertheless, the presence of tumor heterogeneity and the intricate DNA repair mechanisms pose challenges to the effective implementation of synthetic lethality. This review aims to explore the concepts, dev...

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The power and the promise of synthetic lethality for clinical application in cancer treatment

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