Molecular Cloning and Functional Characterization of a beta-Glucosidase Gene to Produce Platycodin D in Platycodon grandiflorus

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成果类型：

期刊论文

作者：

Su, Xinglong;Meng, Fei;Liu, Yingying;Jiang, Weimin;Wang, Zhaojian;...

通讯作者：

Xing, S.

作者机构：

[Wu, Liping; Guo, Xiaohu; Xing, Shihai; Su, Xinglong; Yao, Xiaoyan; Wang, Zhaojian; Wu, Jing; Zha, Liangping; Peng, Daiyin; Meng, Fei; Gui, Shuangying] Anhui Univ Chinese Med, Sch Pharm, Hefei, Peoples R China.

[Xing, Shihai; Su, Xinglong; Zha, Liangping; Peng, Daiyin] Anhui Acad Chinese Med, Inst Tradit Chinese Med Resources Protect & Dev, Hefei, Peoples R China.

[Liu, Yingying] Anhui Univ Chinese Med, Coll Humanities & Int Educ Exchange, Hefei, Peoples R China.

[Jiang, Weimin] Hengyang Normal Univ, Coll Life Sci & Environm, Hengyang, Peoples R China.

[Sun, Zongping] Fuyang Normal Univ, Engn Technol Res Ctr Antiaging, Chinese Herbal Med, Fuyang, Peoples R China.

通讯机构：

[Xing, S.] S

School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China

语种：

英文

关键词：

Platycodon grandiflorus;Triterpenoid saponins;β-glucosidase;Subcellular localization;functional characterization

期刊：

FRONTIERS IN PLANT SCIENCE

ISSN：

1664-462X

年：

2022

卷：

页码：

955628

DOI：

10.3389/fpls.2022.955628

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant No. U21A20406), the NSF of Anhui Province (Grant No. 1908085MH268), the Anhui University Collaborative Innovation Project (Grant Nos. GXXT-2019-043 and GXXT-2019-049), the Foundation of Hunan Key Laboratory for Conservation and Utilization of Biological Resources in the Nanyue Mountainous Region (Grant No. NY20K04), and Key Natural Science Research Projects in Anhui Universities (Grant No. KJ2021A0676).

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院系归属：

生命科学与环境学院

摘要：

Platycodin D (PD) is a deglycosylated triterpene saponin with much higher pharmacological activity than glycosylated platycoside E (PE). Extensive studies in vitro showed that the transformation of platycoside E to platycodin D can be achieved using β-glucosidase extracted from several bacteria. However, whether similar enzymes in Platycodon grandiflorus could convert platycoside E to platycodin D, as well as the molecular mechanism underlying the deglycosylation process of platycodon E, remain unclear. Here, we identified a β-glucosidase in ...

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Molecular Cloning and Functional Characterization of a beta-Glucosidase Gene to Produce Platycodin D in Platycodon grandiflorus

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