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Design, synthesis and mechanistic studies of novel arylformylhydrazone butylphenyltin complexes as potential anticancer agents

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成果类型:
期刊论文
作者:
Jiang, Wujiu*;Fan, Shanji;Zhu, Zhihua;Huang, Huifen;Tan, Yuxing;...
通讯作者:
Jiang, Wujiu;Peng, YY
作者机构:
[Jiang, Wujiu; Jiang, WJ; Peng, Yiyuan] Jiangxi Normal Univ, Coll Chem & Chem Engn, Key Lab Green Chem Jiangxi Prov, Nanchang 330022, Jiangxi, Peoples R China.
[Jiang, Wujiu; Tan, Yuxing; Huang, Huifen; Zhu, Zhihua] Hengyang Normal Univ, Coll Hunan Prov, Key Lab Funct Met Organ Cpds Hunan Prov, Coll Chem & Mat Sci,Key Lab Organometall New Mat, Hengyang 421008, Hunan, Peoples R China.
[Fan, Shanji] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Breast & Thyroid Surg, Hengyang 421000, Hunan, Peoples R China.
通讯机构:
[Jiang, WJ; Peng, YY ] J
Jiangxi Normal Univ, Coll Chem & Chem Engn, Key Lab Green Chem Jiangxi Prov, Nanchang 330022, Jiangxi, Peoples R China.
语种:
英文
关键词:
Acylhydrazone;Anticancer activity;Anticancer mechanisms;Butylphenyltin;Organotin;Synthesis
期刊:
Bioorganic Chemistry
ISSN:
0045-2068
年:
2024
卷:
149
页码:
107502
基金类别:
CRediT authorship contribution statement Wujiu Jiang: Writing – review & editing, Writing – original draft, Methodology, acquisition, Conceptualization. Shanji Fan: Validation, Methodology, Investigation, Formal analysis. Zhihua Zhu: Validation, Investigation, Formal analysis. Huifen Huang: Validation, Investigation, Formal analysis. Yuxing Tan: Writing – review & editing, Writing – original draft. Yiyuan Peng: Writing – review & editing, Writing – original draft, Project administration, acquisition.
机构署名:
本校为其他机构
院系归属:
化学与材料科学学院
摘要:
Many diorganotin complexes with various alkyl groups exhibit excellent in vitro anticancer activity. However, most diorganotin is the same alkyl group, and the asymmetric alkyl R group has been rarely reported. Hence, in this paper, twenty butylphenyl mixed dialkyltin arylformylhydrazone complexes have been synthesized by microwave "one-pot" reaction with arylformylhydrazine, substituted α-keto acid or its sodium salt and butylphenyltin dichloride. The crystal structures of nine complexes were determined, indicating that the complexes C1, C2, ...

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