The rational modeling of College Students' mental health quality can make an accurate analysis of College Students' mental state and provide theoretical basis for eliminating college students' psychology. It was researched on College Students' psychological health quality optimization modeling and simulation. First it elaborated the fuzzy clustering algorithm. Then the algorithm model of College Students' psychological principle based on information system. Finally the algorithm was tested on the experiment and simulation. Synthetic data sets and gets the conclusion: this algorithm has obtaine...