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Engineering Neutral Probes for Investigating the Role of ROS in the Formation of G4s by Fluorescence Imaging in Tumor Cells

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成果类型:
期刊论文
作者:
Chen, Taiyi;Long, Shufa;Liu, Junjie;Jiang, Lu;Zeng, Rongying;...
通讯作者:
Chen, W
作者机构:
[Tang, Siping; Liu, Mengqin; Chen, Taiyi; Long, Shufa; Chen, Wen; Zeng, Rongying; Jiang, Lu; Zhang, Shuping; Liu, Junjie] Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Organometall Mat, Coll Hunan Prov, Hengyang 421008, Peoples R China.
通讯机构:
[Chen, W ] H
Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Organometall Mat, Coll Hunan Prov, Hengyang 421008, Peoples R China.
语种:
英文
关键词:
G4s;ROS;Fluorescence imaging;Flow cytometry
期刊:
Sensors and Actuators B-Chemical
ISSN:
0925-4005
年:
2025
卷:
444
页码:
138498
基金类别:
CRediT authorship contribution statement Taiyi Chen: Investigation, Formal analysis, Data curation. Shufa Long: Formal analysis, Data curation, Conceptualization. Shuping Zhang: Writing – original draft, Conceptualization. Wen Chen: Writing – review & editing, Visualization, acquisition, Conceptualization. Liu Mengqing: Writing – original draft, acquisition, Formal analysis, Conceptualization. Siping Tang: Conceptualization. Rongying Zeng: Writing – original draft, acquisition, Data curation, Conceptualization.
机构署名:
本校为第一且通讯机构
院系归属:
化学与材料科学学院
摘要:
Endogenous G-quadruplexes (G4s) and reactive oxygen species (ROS) form a complex regulatory network in tumors, and their interaction is both a key link in tumor development and provides a breakthrough for the development of new diagnostic and therapeutic approaches. Although reports on the activation of G4s fluorescent probes are common, fluorescent probes suitable for studying the relationship between intracellular G4s and ROS are extremely rare. In this work, we successfully synthesized a series of novel neutral G4s-targeting molecules (PMT, ...

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