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Lactic acid bacteria that activate immune gene expression in Caenorhabditis elegans can antagonise Campylobacter jejuni infection in nematodes, chickens and mice

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成果类型:
期刊论文
作者:
Jin Xing;He Yufeng;Zhou Yonghua;Chen Xiaohua;Lee Yuan-Kun;...
通讯作者:
Wang, Gang
作者机构:
[Zhang Hao; Chen Wei; Wang Gang; He Yufeng; Zhao Jianxin; Jin Xing] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
[Zhang Hao; Chen Wei; Wang Gang; He Yufeng; Zhao Jianxin; Jin Xing] Jiangnan Univ, Schl Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
[Zhou Yonghua] Jiangsu Inst Parasit Dis, Jiangsu Prov Key Lab Parasite & Vector Control Te, Key Lab Natl Hlth & Family Plann Commis, Parasit Dis Control & Prevent, Wuxi 214064, Jiangsu, Peoples R China.
[Chen Xiaohua] Hengyang Normal Univ, Coll Life Sci & Environm, Hengyang 421008, Peoples R China.
[Lee Yuan-Kun] Natl Univ Singapore, Dept Microbiol & Immunol Natl, Singapore 117597, Singapore.
通讯机构:
[Wang, Gang] S
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, P. R. China.
School of Food Science and Technology, Jiangnan University, Wuxi, 214122, P. R. China.
International Joint Research Laboratory for Probiotics, Jiangnan University, Wuxi, 214122, P. R. China.
(Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou, 225004, P. R. China.
语种:
英文
关键词:
Lactic acid bacteria;Campylobacter jejuni;Caenorhabditis elegans;Life-span;Immune gene
期刊:
BMC Microbiology
ISSN:
1471-2180
年:
2021
卷:
21
期:
1
页码:
1-14
基金类别:
This work was supported by the National Natural Science Foundation of China (No. 31671839, 31972052, 31820103010, 31601444, 31301407), the Fundamental Research Funds for the Central Universities (JUSRP22006, JUSRP51501), the national first-class discipline program of Food Science and Technology (JUFSTR20180102), the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province and the research supported by Hunan Provincial Natural Science Foundation of China (2019JJ50014) who approved the design of the study and collection, analysis, interpretation of data and final manuscript.
机构署名:
本校为其他机构
院系归属:
生命科学与环境学院
摘要:
Campylobacter jejuni is the major micro-bacillary pathogen responsible for human coloenteritis. Lactic acid bacteria (LAB) have been shown to protect against Campylobacter infection. However, LAB with a good ability to inhibit the growth of C. jejuni in vitro are less effective in animals and animal models, and have the disadvantages of high cost, a long cycle, cumbersome operation and insignificant immune response indicators. Caenorhabditis elegans is increasingly used to screen probiotics for their anti-pathogenic properties. However, no research on the use of C. elegans to screen for probio...

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