Deciphering cell–cell interactions and communication in the tumor microenvironment and unraveling intratumoral genetic heterogeneity via single-cell genomic sequencing

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cao, Ya-Hong;Ding, Jie;Tang, Qing-Hai;Zhang, Jie;Huang, Zhong-Yan;...

通讯作者：

Fu, D

作者机构：

[Cao, Ya-Hong] Nantong Univ, Nantong Tradit Chinese Med Hosp, Dept Resp, Affiliated Nantong Tradit Chinese Med Hosp, Nantong, Jiangsu, Peoples R China.

[Ding, Jie] Jingjiang Tradit Chinese Med Hosp, Dept Clin Lab, Jingjiang, Jiangsu, Peoples R China.

[Tang, Qing-Hai] Hengyang Normal Univ, Coll Life Sci & Environm, Hunan Key Lab Conservat & Utilizat Biol Resources, Hengyang, Hunan, Peoples R China.

[Zhang, Jie] Nantong Univ, Sch Med, Dept Immunol, Nantong, Jiangsu, Peoples R China.

[Tang, Xiao-Mei; Fu, Da; Huang, Zhong-Yan] Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Pancreat Dis, Sch Med, Shanghai, Huangpu, Peoples R China.

通讯机构：

[Fu, D ] S

Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Pancreat Dis, Sch Med, Shanghai, Huangpu, Peoples R China.

语种：

英文

关键词：

ScRNA-seq;TME;heterogeneity;genome evolution;cell-cell interactions

期刊：

Bioengineered

ISSN：

2165-5979

年：

2022

卷：

期：

7-12

页码：

14974-14986

DOI：

10.1080/21655979.2023.2185434

基金类别：

The work was supported by theNatural Science Foundation of Hunan Province [2021JJ30060]. We would like to thank Dr. Wei Zhang for data analysis and critical discussion of the manuscript.

机构署名：

本校为其他机构

院系归属：

生命科学与环境学院

摘要：

A tumor’s heterogeneity has important implications in terms of its clonal origin, progression, stemness, and drug resistance. Therefore, because of its significance in treatment, it is important to understand the gene expression pattern of a single cell, track gene expression or mutation in heterogeneous cells, evaluate the clonal origin of cancer cells, and determine the selective evolution of different subpopulations of cancer cells. Researchers are able to trace a cell’s mutation and identify different types of tumor cells by measuring the...

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Deciphering cell–cell interactions and communication in the tumor microenvironment and unraveling intratumoral genetic heterogeneity via single-cell genomic sequencing

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