Azafullerene is one of the heterofullerenes which has been paid much attention.Open-cage fullerene derivatives are key intermediates to form aza[60]fullerene.However,the research of N-MEM-ketolactam derivative which is the precursor compound of azafullerene,is still quite rare.In this study,the electrophilic aromatic substitution reaction of N-MEM-ketolactam derivative with electron-rich aromatic hydrocarbons was extensively studied.The results indicate that the reaction afforded the monosubstituted aza[60]fullerene along with other two new by-products.Both of the by-products have been isolate...