Piccolo was the one of important lightweight cryptographic algorithms as Io T cipher in the recent years. This paper researched the hardware optimization method of Piccolo encryption algorithm. The same round operation was achieved only once and repeated call. The original algorithm of Piccolo had r round operation. The key size of Piccolo was 80-bit /128-bit,the corresponding round number was 25 /31. The optimal method made the r- 1 round repeated calling into the r round operation repeated calling. It constructed a RP- 1function after the r round operation. The experimental results show that...