Structural Foundation for Insect-Selective Activity of Acylpolyamine Toxins from Spider Araneus ventricosus.

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成果类型：

期刊论文

作者：

Liu, Kai;Wang, Meichi;Jiang, Liping;Tang, Xing;Liu, Zhen;...

通讯作者：

Duan, Zhigui;Liang, Songping

作者机构：

[Wang, Meichi; Zhou, Zefei; Hu, Weijun; Duan, Zhigui; Liang, Songping; Duan, ZG; Liu, Zhen; Liu, Kai] Hunan Normal Univ, Coll Life Sci, Minist Educ, Key Lab Prot Chem & Dev Biol, Changsha 410081, Hunan, Peoples R China.

[Wang, Meichi; Zhou, Zefei; Hu, Weijun; Duan, Zhigui; Liang, Songping; Duan, ZG; Liu, Zhen; Liu, Kai] Hunan Normal Univ, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha 410081, Hunan, Peoples R China.

[Duan, Zhigui] Hunan Normal Univ, Natl Demonstrat Ctr Expt Biol Educ, Changsha 410081, Hunan, Peoples R China.

[Jiang, Liping] Cent S Univ, Xiangya Med Sch, Dept Parasitol, Changsha 410013, Hunan, Peoples R China.

[Tang, Xing] Hengyang Normal Univ, Coll Life Sci & Environm, Hengyang 421002, Peoples R China.

通讯机构：

[Duan, ZG; Liang, SP; Duan, Zhigui] H

Hunan Normal Univ, Coll Life Sci, Minist Educ, Key Lab Prot Chem & Dev Biol, Changsha 410081, Hunan, Peoples R China.

Hunan Normal Univ, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha 410081, Hunan, Peoples R China.

Hunan Normal Univ, Natl Demonstrat Ctr Expt Biol Educ, Changsha 410081, Hunan, Peoples R China.

语种：

英文

期刊：

CHEMICAL RESEARCH IN TOXICOLOGY

ISSN：

0893-228X

年：

2019

卷：

期：

页码：

659-667

DOI：

10.1021/acs.chemrestox.8b00337

基金类别：

This work was supported by the National Natural Science Foundation of China (31402025) and the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province (No. 20134486) and the National Natural Science Foundation of China (31201718). The use and care of animals in this study followed the guidelines of the Institutional Animal Care and Use Committee of Hunan province.

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本校为其他机构

院系归属：

生命科学与环境学院

摘要：

Spider venoms are insecticidal mixtures with diverse biological activities, and acylpolyamines are their small molecular active components. However, the mechanism for the insecticidal activity of acylpolyamines remains to be elucidated. Here, the structure and function of two acylpolyamine toxins, AVTX-622 and AVTX-636, from Araneus ventricosus were investigated. Nuclear magnetic resonance (NMR) analysis illustrated that the structure of two toxins was very similar, and compared to AVTX-636, AVTX-622 only missed a methylene group in the linker region between the polyamine head and tail. Both t...

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Structural Foundation for Insect-Selective Activity of Acylpolyamine Toxins from Spider Araneus ventricosus.

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