Anti-parasitic effect on Toxoplasma gondii induced by a spider peptide lycosin-I.

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成果类型：

期刊论文

作者：

Tang, Yaqin;Hou, Shengjie;Li, Xianyao;Wu, Mengqi;Ma, Binbin;...

通讯作者：

Jiang, Liping

作者机构：

[Wu, Mengqi; Hou, Shengjie; Li, Xianyao; Han, Xiaoqing; Liu, Yuan; Ma, Binbin; Tang, Yaqin; Wang, Wenhua; Jiang, Liping] Cent S Univ, Xiangya Sch Med, Dept Parasitol, Changsha 410013, Hunan, Peoples R China.

[Wang, Zheng] Cent S Univ, Xiangya Hosp 3, Dept Gen Surg 1, Changsha 410013, Hunan, Peoples R China.

[Jiang, Jinying] Hunan Prov Maternal & Child Hlth Care Hosp, Dept Neonatol, Changsha 410013, Hunan, Peoples R China.

[Deng, Meichun] Cent S Univ, Sch Life Sci, Dept Biochem, Changsha 410013, Hunan, Peoples R China.

[Duan, Zhigui] Hunan Normal Univ, Coll Life Sci, Minist Educ, Key Lab Prot Chem & Dev Biol, Changsha 410081, Hunan, Peoples R China.

通讯机构：

[Jiang, Liping] C

Cent S Univ, Xiangya Sch Med, Dept Parasitol, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

Anti-parasitic;Invasion;Lycosin-I;Proliferation;Spider peptide;Toxoplasma gondii

期刊：

Experimental Parasitology

ISSN：

0014-4894

年：

2019

卷：

198

页码：

17-25

DOI：

10.1016/j.exppara.2019.01.009

基金类别：

The authors would like to thank Prof. Hongjuan Peng, Southern Medical University (Guangzhou, China), for providing the RH strain of T. gondii and HFF cells. This work was supported by Hunan Provincial Natural Science Foundation of China (grant numbers 2017JJ2372 , 2015JJ2192 ); China Postdoctoral Science Fund Project (first class) (grant number 2015M580704 ); Central South University Teachers Research Fund (grant number 2014JSJJ027 ); the National Natural Science Foundation of China (grant number 31672290 ) and National Undergraduate Innovation Training Program of Central South University (grant numbers 201610533535 , ZY20170972 , 201810533037 ).

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本校为其他机构

院系归属：

生命科学与环境学院

摘要：

Toxoplasmosis is a widely distributed parasitic protozoan disease, caused by Toxoplasma gondii (T. gondii). High prevalence of toxoplasmosis and limitations of conventional treatments lead to a search for new therapeutic drugs. Lycosin-I is a linear peptide, derived from the venom of the spider Lycosa singoriensis. The aim of the present study was to determine the anti-parasitic effect of lycosin-Iota against T. gondii. In vitro, the anti-T. gondii activities of lycosin-Iota were evaluated by MTT assay, trypan blue exclusion assay, cell counting assay and plaque assay. Cytokines of IL-6 and IL...

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Anti-parasitic effect on Toxoplasma gondii induced by a spider peptide lycosin-I.

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