Mono-modified beta-cyclodextrins ligands, L-1 (6-mono-(N-aminoethyl)amino-beta-cyclodextrin) and L-2 (6-mono-(N-(pyridin-2-yl)ethylamino)-beta-cyclodextrin), and their platinum(II) complexes, 1 ([Pt(L-1)Cl-2]center dot 8H(2)O) and 2 ([Pt(L-2)Cl-2]center dot 4H(2)O), were successfully synthesized. As revealed by UV-Vis and CD spectroscopic studies, both complexes mainly adopt a non-intercalative mode with DNA. The interaction between platinum complex 1 and DNA was obviously observed in agarose Gel Electrophoresis. Meanwhile, two ligands L-1, L-2 and platinum complex 2 have no obvious interactio...
