Multi-omics analysis identifies a liquid-liquid phase separation-related subtypes in head and neck squamous cell carcinoma

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成果类型：

期刊论文

作者：

Zhai, Peng-Lei;Chen, Meng-Min;Wang, Qi;Zhao, Jing-Jun;Tang, Xiao-Mei;...

通讯作者：

Tang, Si-Ping;Fu, D

作者机构：

[Tang, Si-Ping; Zhang, Shu-Ping; Fu, Da; Zhao, Jing-Jun; Gu, Biao; Zhai, Peng-Lei] Hengyang Normal Univ, Key Lab Funct Organometall Mat Coll Hunan Prov, Coll Chem & Mat Sci, Hengyang, Peoples R China.

[Tang, Xiao-Mei; Fu, Da; Lu, Cui-Ni; Chen, Meng-Min; Yang, Qin-Xin; Zhai, Peng-Lei; Liu, Jia] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Gen Surg,Pancreat Dis Ctr, Shanghai, Peoples R China.

[Chen, Meng-Min] Shanghai Jiao Tong Univ, Res Inst Pancreat Dis, Sch Med, Shanghai Key Lab Translat Res Pancreat Neoplasms, Shanghai, Peoples R China.

[Chen, Meng-Min] Shanghai Jiao Tong Univ, Inst Translat Med, State Key Lab Oncogenes & Related Genes, Shanghai, Peoples R China.

[Wang, Qi] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Urol, Shanghai, Peoples R China.

通讯机构：

[Tang, SP; Fu, D ] H

Hengyang Normal Univ, Key Lab Funct Organometall Mat Coll Hunan Prov, Coll Chem & Mat Sci, Hengyang, Peoples R China.

Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Gen Surg,Pancreat Dis Ctr, Shanghai, Peoples R China.

语种：

英文

关键词：

drug prediction;genomic alterations;immunotherapy;liquid-liquid phase separation;tumor immune microenvironment

期刊：

FRONTIERS IN ONCOLOGY

ISSN：

2234-943X

年：

2025

卷：

页码：

1509810

DOI：

10.3389/fonc.2025.1509810

基金类别：

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was partially supported by Shanghai Natural Science Foundation (20ZR1472400), Scientific Research Key project of Hunan Provincial Department of Education (23A0519), Hunan Provincial Natural Science Foundation of China (2022JJ30098).

机构署名：

本校为第一且通讯机构

院系归属：

化学与材料科学学院

摘要：

BACKGROUND: Growing evidence indicates that abnormal liquid-liquid phase separation (LLPS) can disrupt biomolecular condensates, contributing to cancer development and progression. However, the influence of LLPS on the prognosis of head and neck squamous cell carcinoma (HNSCC) patients and its effects on the tumor immune microenvironment (TIME) are not yet fully understood. Therefore, we aimed to categorize patients with HNSCC based on LLPS-related genes and explored their multidimensional heterogeneity. METHODS: We integrated the transcriptomic data of 3,541 LLPS-related genes to assess the L...

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Multi-omics analysis identifies a liquid-liquid phase separation-related subtypes in head and neck squamous cell carcinoma

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