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Multi-omics analysis identifies a liquid-liquid phase separation-related subtypes in head and neck squamous cell carcinoma.

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成果类型:
期刊论文
作者:
Zhai, Peng-Lei;Chen, Meng-Min;Wang, Qi;Zhao, Jing-Jun;Tang, Xiao-Mei;...
作者机构:
[Zhang, Shu-Ping; Zhao, Jing-Jun; Gu, Biao; Tang, Si-Ping; Fu, Da; Zhai, Peng-Lei] Key Laboratory of Functional Organometallic Materials of College of Hunan Province, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, China
[Tang, Xiao-Mei; Lu, Cui-Ni; Chen, Meng-Min; Yang, Qin-Xin; Fu, Da; Zhai, Peng-Lei; Liu, Jia] Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
[Chen, Meng-Min] Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, China
[Chen, Meng-Min] State Key Laboratory of Oncogenes and Related Genes, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China
[Wang, Qi] Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
语种:
英文
关键词:
drug prediction;genomic alterations;immunotherapy;liquid-liquid phase separation;tumor immune microenvironment
期刊:
FRONTIERS IN ONCOLOGY
ISSN:
2234-943X
年:
2025
卷:
15
页码:
1509810
机构署名:
本校为第一机构
院系归属:
化学与材料科学学院
摘要:
BACKGROUND: Growing evidence indicates that abnormal liquid-liquid phase separation (LLPS) can disrupt biomolecular condensates, contributing to cancer development and progression. However, the influence of LLPS on the prognosis of head and neck squamous cell carcinoma (HNSCC) patients and its effects on the tumor immune microenvironment (TIME) are not yet fully understood. Therefore, we aimed to categorize patients with HNSCC based on LLPS-related genes and explored their multidimensional heterogeneity. METHODS: We integrated the transcriptomic data of 3,541 LLPS-related genes to assess the L...

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