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Synthesis, Characterization, and Biological Activity of Six Di-p-chlorobenzyltin Complexes Derived from ONO Tridentate Ligands

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成果类型:
期刊论文
作者:
Tan, Yuxing;Qin, Qiqi;Li, Aodian;Fu, Weiwei;Jiang, Wujiu
通讯作者:
Jiang, WJ
作者机构:
[Jiang, Wujiu; Li, Aodian; Tan, Yuxing; Qin, Qiqi; Jiang, WJ; Fu, Weiwei] Hengyang Normal Univ, Univ Hunan Prov, Key Lab Funct Met Organ Cpds Hunan Prov, Coll Chem & Mat Sci,Key Lab Funct Organometall Mat, Hengyang 421008, Hunan, Peoples R China.
通讯机构:
[Jiang, WJ ] H
Hengyang Normal Univ, Univ Hunan Prov, Key Lab Funct Met Organ Cpds Hunan Prov, Coll Chem & Mat Sci,Key Lab Funct Organometall Mat, Hengyang 421008, Hunan, Peoples R China.
语种:
英文
关键词:
Bioactivity;Cell culture;Chelation;Complexation;Crystal structure;DNA;Fluorescence spectroscopy;Nuclear magnetic resonance spectroscopy;Organometallics;Single crystals;Tin compounds;Anticancer activities;Arylformylhydrazone;Crystals structures;NMR spectrum;OH -;Organotins;Pyruvates;Synthesised;Tridentate ligands;X-ray single-crystal diffraction;Synthesis (chemical)
期刊:
Journal of Organometallic Chemistry
ISSN:
0022-328X
年:
2023
卷:
1002
页码:
122905
基金类别:
This work was supported by the Natural Science Foundation of Hunan Province (No. 2022JJ30096 ), the Hengyang Normal University Industrial Supported Project (No. HXKY2022047 ), the Innovation Platform Open Fund Project of Hunan Provincial Education Department of China (No. 20K016 ), and the Foundation of Key Laboratory of Functional Metal-Organic Compounds of Hunan Province (No. 2022HSKFJJ028 ).
机构署名:
本校为第一且通讯机构
院系归属:
化学与材料科学学院
摘要:
Six new di-p-chlorobenzyltin complexes {[X-C6H4(O)C=N-N=C(Me)COO](MeOH)(p-Cl-C6H4CH2)2Sn}2 (X= 2-OH- (C1), 4-OH- (C2), 4-NO2- (C3), 4-t-Bu-(C4), 4-MeO-(C5) or 4-Me- (C6)) were synthesized by the reactions of substituted arylhydrazides, sodium pyruvate, and di(p-chlorobenzyl)tin dichloride. All the complexes were characterized by IR, 1H, 13C, 119Sn NMR spectra, HRMS, X-ray single crystal diffraction, and TGA. The complexes (C1∼C6) were screened for their in vitro anticancer activity against MCF-7, HepG2, and NCI-H460 cancer cell lines. In those...

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