Six new di-p-chlorobenzyltin complexes {[X-C6H4(O)C=N-N=C(Me)COO](MeOH)(p-Cl-C6H4CH2)2Sn}2 (X= 2-OH- (C1), 4-OH- (C2), 4-NO2- (C3), 4-t-Bu-(C4), 4-MeO-(C5) or 4-Me- (C6)) were synthesized by the reactions of substituted arylhydrazides, sodium pyruvate, and di(p-chlorobenzyl)tin dichloride. All the complexes were characterized by IR, 1H, 13C, 119Sn NMR spectra, HRMS, X-ray single crystal diffraction, and TGA. The complexes (C1∼C6) were screened for their in vitro anticancer activity against MCF-7, HepG2, and NCI-H460 cancer cell lines. In those...