作者机构：
[Wang, Deping] Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Organometall Mat, Hengyang 421008, Hunan, Peoples R China.;[He, Yongqiang; Xia, Xiaohong; Liu, Hongbo] Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Hunan, Peoples R China.;[Xia, Xiaohong] Hunan Univ, Hunan Joint Int Lab Adv Mat & Technol Clean Energy, Changsha 410082, Hunan, Peoples R China.
通讯机构：
[Xiaohong Xia] C;College of Material Science and Engineering, Hunan University, Changsha, Hunan 410082, PR China<&wdkj&>Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy, Hunan University, Changsha, Hunan 410082, PR China
摘要：
Nitric oxide (NO), an essential biological messenger molecule, participates in various physiological and pathological processes. The sensitive and specific detection of NO is of great significance for understanding the biological function of NO. Here, we synthesized a fluorescent probe (Rho-NO) for highly selective detection of NO both in vitro and in vivo. The high selectivity of Rho-NO is attributed to the fact that NO is easily replaced by electron donor amino group to form N-nitrosation products, causing rhodamine spiro ring open and fluorescence emit. Rho-NO showed a good linear response to NO (0-100 mu M) with a low detection limit (0.06 mu M). Importantly, it exhibited excellent specificity for NO detection in human serum and was also applied for imaging NO in living cells and inflammatory model of zebrafish. This work proves the potential of Rho-NO in pathological research and disease diagnosis. (C) 2021 Elsevier B.V. All rights reserved.
期刊：
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES,2022年38(9):848-857 ISSN：1607-551X
通讯作者：
Hong Huang<&wdkj&>Ze-Cheng Hu
作者机构：
[Shen, Ying-Ying; Xu, Jia-Chi; Fan, Shan-Ji; Hu, Ze-Cheng; Li, Yue-Hua; Huang, Hong] Univ South China, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.;[Cui, Ying] Hengyang Normal Univ, Coll Chem & Mat Sci, Hengyang, Hunan, Peoples R China.
通讯机构：
[Hong Huang; Ze-Cheng Hu] T;The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China
关键词：
breast cancer;CASC9;invasion;SOX4;STAT3
摘要：
Numerous long noncoding RNAs (lncRNAs) are abnormally expressed in breast cancer (BC), but the underlying mechanisms remain large unknown. Here, we aimed to investigate the functions and mechanisms of lncRNA cancer susceptibility candidate 9 (CASC9) in BC. Western blotting and quantitative real-time PCR (qRT-PCR) were performed to assess gene and protein expression, respectively. The proliferative and metastatic abilities of BC cells were tested by cell counting kit-8 and transwell assays, respectively. The formation of lymphatic vessels was detected by tube formation assay. Chromatin immunoprecipitation (ChIP) and dual luciferase reporter assays were performed to verify molecular interactions. CASC9 was found to be highly expressed in BC tissues and cell lines, and ectopic overexpression was positively associated with tumor volume, TNM stage, and lymph node metastasis. In addition, CASC9 silencing significantly inhibited the proliferation and invasion of BC cells, as well as BC-associated invasion and formation of lymphatic vessels of human dermal lymphatic endothelial cells. Mechanical studies demonstrated that CASC9 could be transcriptionally activated by STAT3 and elevate SOX4 expression by enhancing the acetylation of its promoter region. Our results illustrated that STAT3-activated CASC9 served as a tumor-promoting gene involved in promoting BC invasion and BC-associated formation of lymphatic vessels by upregulating SOX4 through altering H3K27ac level. This finding elucidated a new underlying network of CASC9 in the metastasis of BC.
期刊：
Journal of Organometallic Chemistry,2022年980-981:122491 ISSN：0022-328X
通讯作者：
Ya-Ping Ou<&wdkj&>Sheng Hua Liu
作者机构：
[Ou, Ya-Ping; Kong, Lingqiao; Lin, Zishun] Hengyang Normal Univ, Coll Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.;[Ou, Ya-Ping; Kong, Lingqiao; Lin, Zishun] Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Hengyang 421008, Peoples R China.;[Ou, Ya-Ping; Kong, Lingqiao; Lin, Zishun] Hengyang Normal Univ, Key Lab Funct Organometall Mat Hunan Prov Coll, Hengyang 421008, Hunan, Peoples R China.;[Ou, Ya-Ping; Kong, Lingqiao; Lin, Zishun] Hunan Engn Res Ctr Monitoring & Treatment Heavy Me, Hengyang 421001, Hunan, Peoples R China.;[Liu, Sheng Hua; Yang, Xiaofei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Ya-Ping Ou] C;[Sheng Hua Liu] K;Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China<&wdkj&>College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, PR China<&wdkj&>Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Hengyang Normal University, Hengyang 421008, PR China<&wdkj&>Key Laboratory of Functional Organometallic Materials of Hunan Province College, Hengyang Normal University, Hengyang, Hunan 421008, PR China<&wdkj&>Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the upper Reaches of Xiangjiang River, Hengyang, Hunan 421001, PR China
摘要：
Isomeric diruthenium complexes with bis(ethynyl)pyridine as bridge core [2,6-bis(ethynyl)pyridine ( 1 ), 3,5-bis(ethynyl)pyridine ( 2 ), 2,5-bis(ethynyl)pyridine ( 3 )] were successfully prepared and characterized by 1 H NMR, 13 C NMR and elemental analysis. The electrochemical properties of complexes 1-3 were inves-tigated by cyclic voltammetry (CV) and square-wave voltammetry (SWV), and different potential differ-ence values were revealed and affected by N atom position and distance between redox metal centers. Electron absorption spectra showed that the absorption of the linear molecule 3 displayed a red shift relative to that of complexes 1 and 2 . The broad near-infrared absorption characteristic of the singly -oxidized complex 3 + revealed the existence of a mixed-valence state, which can be classified as a class II mixed-valence system according to the intervalence charge transfer (IVCT) absorption parameter Hab and <SIC> CYRILLIC CAPITAL LETTER GHE. These results indicated that 3 has higher conjugation and charge delocalization ability than isomers 1 and 2 . Density functional theory (DFT) calculations spin density distribution analysis further confirmed the above results, and time-dependent DFT showed the NIR multi-absorption of complex 3 +, and effec-tively attributed to Ru-C equivalent to C -> Ru IVCT absorption characteristics.(c) 2022 Elsevier B.V. All rights reserved.
期刊：
EUROPEAN PHYSICAL JOURNAL B,2022年95(7):107-null ISSN：1434-6028
通讯作者：
Zhang, Zhijian(zhangzhijian_cn@126.com)
作者机构：
[Zhang, Zhijian] Hengyang Normal Univ, Key Lab Funct Met Organ Cpds, Hengyang 421001, Peoples R China.;[Zhang, Zhijian] Hengyang Normal Univ, Key Lab Funct Organometall Mat Hunan Prov, Hengyang 421001, Peoples R China.;[Shi, Wei] Hunan Prov Sci & Technol Affairs Ctr, Changsha 410013, Peoples R China.;[Shi, Wei] Sci & Technol Dept Hunan Prov, Changsha 410013, Peoples R China.
通讯机构：
[Zhijian Zhang] K;Key Laboratory of Functional Metal-Organic Compounds and Key Laboratory of Functional Organometallic Materials of Hunan Province, Hengyang Normal University, Hengyang, China
关键词：
The European Physical Journal B;Condensed Matter;Complex Systems;journal;EPJ
作者机构：
[Sun, Junbin; Lu, Weihong; Qi, Xiang; Xu, Zhifeng; Huang, Ling; Chen, Ting; Song, Chenxi; Wang, Juan] Hengyang Normal Univ, Coll Chem & Mat Sci, Hengyang 421008, Peoples R China.;[Sun, Junbin; Lu, Weihong; Xu, Zhifeng] Hengyang Normal Univ, Key Lab Organometall New Mat Hunan Prov, Hengyang 421008, Peoples R China.;[Sun, Junbin; Lu, Weihong; Xu, Zhifeng] Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Hengyang 421008, Peoples R China.;[Sun, Junbin; Lu, Weihong; Xu, Zhifeng] Hengyang Normal Univ, Hunan Engn Res Ctr Monitoring & Treatment Heavy M, Hengyang 421008, Peoples R China.;[Chen, Xiaolong] Jinan Univ, Inst Adv Wear & Corros Resistant & Funct Mat, Guangzhou 510632, Peoples R China.
通讯机构：
[Junbin Sun; Weihong Lu] C;College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, PR China<&wdkj&>Key Laboratory of Organometallic New Materials of Hunan Province, Hengyang Normal University, Hengyang, 421008, PR China<&wdkj&>Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Hengyang Normal University, Hengyang, 421008, PR China<&wdkj&>Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Hengyang Normal University, Hengyang, 421008, PR China
通讯机构：
[Xu, ZF; Li, JH ; Wang, ZQ; Wang, CY] H;Hengyang Normal Univ, Univ Hunan Prov, Coll Chem & Mat Sci,Key Lab Funct Organometall Ma, Key Lab Funct Met Organ Cpds Hunan Prov, Hengyang 421008, Peoples R China.;Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Contro, Nanchang 330063, Jiangxi, Peoples R China.
摘要：
We report here a DTBP-mediated oxidative [4 + 2]/[3 + 2] annulation between 2-alkynylbenzaldehydes and terminal arylalkenes enabled by aldehyde C(sp2)–H functionalization for assembling a range of benzo[a]fluoren-5-ones with high step-economy, simple operation under metal-/solvent-free conditions and excellent functional group tolerance. This method is initiated from 2-alkynylbenzaldehyde reaction partners and provides a useful new strategy to construct complex benzo[a]fluoren-5-one scaffolds compared to existing protocols initiating from alkene reaction partners.
作者机构：
[Chen Jing-Jiao; Zhao Bin-Jie; Deng Xin; Zhou Yu-Lin; Xu Sai-Nan; Li Fang-Fang; Zhang Fu-Xing; Tian Jie; Zhu Xiao-Ming] Hengyang Normal Univ, Hunan Engn Res Ctr Monitoring & Treatment Heavy M, Dept Chem & Mat Sci,Key Lab Organometall New Mat, Key Lab Funct Met Organ Cpds Hunan Prov, Hengyang 421008, Hunan, Peoples R China.
作者机构：
[Jiang, Wujiu; Tan, Yuxing; Ding, Qiuping; Fu, Yang] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Mol, Key Lab Green Chem Jiangxi Prov, 99 Ziyang Ave, Nanchang 330022, Jiangxi, Peoples R China.;[Jiang, Wujiu; Tan, Yuxing; Ni, Penghui] Hengyang Normal Univ, Coll Chem & Mat Sci, Hunan Prov Engn Res Ctr Monitoring & Treatment He, Univ Hunan Prov,Key Lab Funct Organometall Mat,Ke, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Yang Fu; Qiuping Ding] K;Key Laboratory for Green Chemistry of Jiangxi Province, Key Laboratory of Functional Small Molecules for Ministry of Education, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, 330022 People's Republic of China
作者机构：
[Liu, Xing; Lai, Hua; Peng, Gang; Li, Junhua; Zeng, Rongying] Hengyang Normal Univ, Coll Chem & Mat Sci, Hengyang 421008, Peoples R China.;[Liu, Xing; Lai, Hua; Peng, Gang; Li, Junhua] Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Hengyang 421008, Peoples R China.;[Liu, Xing; Lai, Hua; Peng, Gang; Li, Junhua] Hengyang Normal Univ, Key Lab Funct Organometall Mat Coll Hunan Prov, Hengyang 421008, Peoples R China.
通讯机构：
[Liu, Xing] H;Hengyang Normal Univ, Coll Chem & Mat Sci, Hengyang 421008, Peoples R China.;Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Hengyang 421008, Peoples R China.;Hengyang Normal Univ, Key Lab Funct Organometall Mat Coll Hunan Prov, Hengyang 421008, Peoples R China.
期刊：
Environmental Science and Pollution Research,2022年29(30):46161-46173 ISSN：0944-1344
通讯作者：
Tang, WQ
作者机构：
[Liu, Yan; Liu, Xing; Wang, Shuzhan; Wang, Zefen; Tang, Wenqing; Chen, Zhen; Yi, Nengzhong; Chen, Jun; Zhou, Qianyi; Zeng, Rongying] Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Organometall Mat Coll Hunan Prov, Hunan Engn Res Ctr Monitoring & Treatment Heavy M, Hengyang 421001, Peoples R China.;[Chen, Jun] Changde Xinfurong Environm Protect Co Ltd, Changde, Peoples R China.
通讯机构：
[Tang, WQ ] H;Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Organometall Mat Coll Hunan Prov, Hunan Engn Res Ctr Monitoring & Treatment Heavy M, Hengyang 421001, Peoples R China.
作者机构：
[Xu, Zhi-Feng; Li, Jin-Heng; Wang, Zhi-Qiang; Yu, Jiang-Xi] Hengyang Normal Univ, Key Lab Funct Organometall Mat, Key Lab Funct Meta Organ Cpds Hunan Prov, Univ Hunan Prov, Hengyang 421008, Peoples R China.;[Wu, Li-Jun] Cent South Univ Forestry & Technol, Coll Sci, Changsha 410004, Peoples R China.;[Li, Jin-Heng] Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Contro, Nanchang 330063, Jiangxi, Peoples R China.;[Li, Jin-Heng] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 475004, Henan, Peoples R China.
通讯机构：
[Li, Jin-Heng] H;[Wu, Li-Jun] C;[Li, Jin-Heng] N;Hengyang Normal Univ, Key Lab Funct Organometall Mat, Key Lab Funct Meta Organ Cpds Hunan Prov, Univ Hunan Prov, Hengyang 421008, Peoples R China.;Cent South Univ Forestry & Technol, Coll Sci, Changsha 410004, Peoples R China.
摘要：
A new method for the synthesis of 3-ethynyl-1-methylene-1,2-dihydronaphthalenes via copper-promoted palladium-catalyzed intermolecular alkynylative [5 + 1] carboannulation of 1-arylphenyl-prop-2-yn-1-yl acetates involving C–H functionalization is described. Two terminal alkyne molecules serve as an alkynylation reagent and a one-carbon unit to enable alkynylative [5 + 1] carboannulation with excellent selectivity control, broad substrate scope and good tolerance of functional groups.
作者机构：
[Lai, Hua; Li, Yulin; Liu, Xuya; Huang, Geng; Li, Wei; Wang, Ping] Hengyang Normal Univ, Coll Chem & Mat Sci, Hengyang 421008, Peoples R China.;[Yang, Po] Sichuan Univ, Coll Polymer Sci & Engn, Chengdu 610065, Peoples R China.
通讯机构：
[Hua Lai; Po Yang] C;College of Polymer Science and Engineering, Sichuan University, Chengdu, China<&wdkj&>College of Chemistry and Material Science, Hengyang Normal University, Hengyang, China
摘要：
Mannich-type polycondensation with 4,4’-diaminodiphenylmethane (DDM), 2,2-bis(4-hydroxyphenol) propane (BPA) and paraformaldehyde (PF) in different solvents was carried out to prepare main-chain benzoxazines. When pure CHCl3 was used as the solvent, the decomposition rate of PF in CHCl3 was very slow, thus preventing gelation caused by the formation of triazine in the early reaction, producing P(B-D)1 composed of partially closed and unclosed structures. The addition of alkaline triethylamine into CHCl3 (CHCl3/triethylamine = 6:1) greatly enhanced the decomposition rate of PF but gave a large triazine gel. The introduction of triethanolamine into CHCl3 was found to promote the decomposition of PF, enhance the polymerization rate, and prevent gelation caused either by the formation of triazine or by the ring-opening of oxazine ring through a solvation effect. Polymers P(B-D) 6~P(B-D)8 obtained in CHCl3/triethanolamine had a high-oxazine content and a high number molecular weight (Mn) near 8000. Further optimization of Mannich-type polycondensation in CHCl3/triethanolamine gave preferred conditions: a CHCl3/triethanolamine ratio of 4:1, a PF of 1.2 eq and a reaction time of 24 h. Compared with P(B-D)1 and P(B-D)3 (obtained in toluene/ethanol), P(B-D)9 obtained under the optimized conditions showed a higher Mn (10,000) and a higher yield (97.0%). The optimized conditions were also applicable for other kinds of diamines and bisphenols. Mannich-type polycondensation of diamines, bisphenols and PF was conducted in CHCl3, CHCl3/triethylamine, and CHCl3/triethanolamine, respectively. The products were greatly affected by the solvents used. Owing to the combination of alkalinity and solvation effect of triethanolamine, CHCl3/triethanolamine was preferable for Mannich-type polycondensation which gave main-chain benzoxazines possessing Mn up to 10,000, oxazine content >80.0% and yield >96.0%.
作者机构：
[Zhang, Jing; Liu, Sheng Hua; Hu, Yu Xuan; Yang, Xiaofei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Deng, Qianqian; Zhu, Jun] Xiamen Univ, Coll Chem & Chem Engn, Collaborat Innovat Ctr Chem Energy Mat iChEM, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China.;[Deng, Qianqian; Zhu, Jun] Xiamen Univ, Coll Chem & Chem Engn, Fujian Prov Key Lab Theoret & Computat Chem, Xiamen 361005, Peoples R China.;[Ou, Ya-Ping] Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Organometall Mat Hunan Prov Coll, Key Lab Funct Met Organ Cpds Hunan Prov, Hengyang, Peoples R China.;[Hartl, Frantisek; Garrett, Emily K.] Univ Reading, Dept Chem, Reading RG6 6DX, Berks, England.
通讯机构：
[Jun Zhu] S;[Sheng Hua Liu] K;[František Hartl] D;State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China<&wdkj&>Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China<&wdkj&>Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6DX, UK<&wdkj&>Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
摘要：
In this work two dicationic diosma-octacyclic complexes have successfully been synthesized and fully characterized. One of them, with aromatic osmapentalene termini linked by the non-aromatic osmafuran moiety to the rigid naphthalenediolate bridge, represents the first example of a fused, fully conjugated dimetalla-octacyclic complex. A reference complex with more flexible biphenolate in the bridging position was also prepared. Their redox and electronic properties were investigated by combined methods of cyclic voltammetry and UV-vis-NIR–IR spectroelectrochemistry, supported by density functional theory (DFT) and time-dependent density functional theory (TD-DFT) calculations. The rigid octacyclic complex forms a stable singly reduced mixed-valence species with the spin density localized at one of the osmapentalene termini.
期刊：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,2022年427:113796 ISSN：1010-6030
通讯作者：
Gu, B;Shen, YM;Long, JM
作者机构：
[Gu, Biao; Guo, Xilin; Wang, Feifei; Guo, Beisong; Gu, B] Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Chem Sensing & Catalysis, Hengyang 421008, Peoples R China.;[Shen, Youming; Shen, YM] Hunan Univ Arts & Sci, Coll Chem & Mat Engn, Changde 415000, Peoples R China.;[Long, Jiumei] Hengyang Normal Univ, Coll Life Sci & Environm, Hengyang 421008, Peoples R China.
通讯机构：
[Long, JM ; Shen, YM ; Gu, B ] H;Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Chem Sensing & Catalysis, Hengyang 421008, Peoples R China.;Hunan Univ Arts & Sci, Coll Chem & Mat Engn, Changde 415000, Peoples R China.;Hengyang Normal Univ, Coll Life Sci & Environm, Hengyang 421008, Peoples R China.
关键词：
Peroxynitrite;Biosensor;ESIPT plus AIE;Rapid response;Cellular imaging
