摘要：
In this paper, carboxylated multi-walled carbon nanotubes (MWCNTs-COOH) functionalized with polyethylenimine (PEI) was prepared and a glassy carbon electrode (GCE) modified with the above nanocomposites (denoted as PEI-MWCNTs-COOH/GCE) was fabricated. Using p-nitrophenol (p-NP) and o-nitrophenol (o-NP) as model compounds, the electrocatalysis of the modified electrode was studied. The results show that the sensitivity and selectivity of the modified electrode are significantly improved due to the synergistic effect of MWCNTs-COOH and PEI. The oxidation peak potentials of o-NP and p-NP were separated by about 60 mV. Second-order derivative linear sweep voltammetry were used for the quantitative analysis of p-NP and o-NP. Under the optimized condition, the linear range for o-NP was 2-100 mu M in the presence of 10 mu M p-NP, while the linear range for p-NP was 0.2-100 mu M in the presence of 10 mu M o-NP. The detection limits were 0.6 mu M and 0.04 mu M for o-NP and p-NP, respectively. The PEI-MWCNTs-COOH/GCE exhibited excellent reproducibility and stability. Finally, the developed sensor was applied for the determination of o-NP and p-NP in environmental water samples with high precision and accuracy.
摘要：
Six new di-p-chlorobenzyltin complexes {[X-C6H4(O)C=N-N=C(Me)COO](MeOH)(p-Cl-C6H4CH2)(2)Sn}(2) (X= 2-OH- (C1), 4-OH- (C2), 4-NO2- (C3), 4-t-Bu-(C4), 4-MeO-(C5) or 4-Me- (C6)) were synthesized by the reactions of substituted arylhydrazides, sodium pyruvate, and di(p-chlorobenzyl)tin dichloride. All the complexes were characterized by IR, H-1, C-13, Sn-119 NMR spectra, HRMS, X-ray single crystal diffraction, and TGA. The complexes (C1 similar to C6) were screened for their in vitro anticancer activity against MCF-7, HepG2, and NCI-H460 cancer cell lines. In those complexes, complex C2 showed promising anticancer activity. The interaction between C2 and calf thymus DNA was studied by UV absorption and fluorescence spectroscopy. The results showed that the interaction between the complex C2 and DNA was intercalation. Molecular docking was also performed to verify the binding specificity of the complex C2 with DNA.
摘要：
Photochromic dithienylethene (DTE) derivatives with aggregation-induced emission (AIE) performance are appealing for photoelectric functional materials and photopharmacology. However, they often have to be trig-gered by ultraviolet light to induce photoisomerization, severely limiting their potential applications in bio-logical systems. Herein, a novel acceptor (A)-acceptor (A) type DTE derivative (CNSDTE) has been rationally designed and prepared, in which the cyanostilbene moieties as strong electron-withdrawing groups are incor-porated into both sides of DTE skeleton. Its chemical structure is fully verified by 1H NMR, 13C NMR and HRMS. Upon alternating irradiation of visible and near-infrared light, CNSDTE shows excellent photochromic properties in toluene, chloroform and DMSO. Before irradiation with visible light, AIE properties and solid state lumines-cence behavior are observed. Furthermore, CNSDTE-loaded nanoparticles (CNSDTE NPs) are facilely fabricated by taking the amphiphilic Pluronic F127 as the encapsulating matrix. The as-prepared CNSDTE NPs display excellent photoswitching behavior in aqueous media. The experimental results of the excellent AIE properties and photoswitching behaviors in the various media is also confirmed by DFT calculations. In short, it may be employed in functional biomaterials as a novel visible light-triggered fluorescence switch with AIE features.
摘要：
Mercury ions (Hg(2+)), as one of heavy transition metals (HTM), is a highly toxic metal that is hazardous to human health. Here an aggregation-induced emission (AIE) fluorescent probe is designed for the highly sensitive and selective detection of Hg(2+). The probe is engineered with a tetraphenylethene (TPE) derivative as the fluorophore and thiopropionic acid as the site of recognition for Hg(2+). Due to the different solubilities of the probe AIE-COOH and its corresponding product after reaction with Hg(2+). The probe demonstrates a maximum detection limit of 22nM and a fast response time of∼100s. Simultaneously, AIE-COOH exhibits outstanding detectivity and hypersensitivity for the detection of Hg(2+) in aqueous solutions. These characteristics demonstrate that AIE-COOH hold a great potential in environmental, food and biological systems. Moreover, we have also successfully applied it to Hg(2+) fluorescence imaging in in living cells.
作者机构：
[Jiang, Wujiu; Tan, Yuxing; Zhang, Zhijian; Ni, Penghui] Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Organomet New Mat,Coll Chem & Mat Sci, Coll Hunan Prov,Hunan Prov Engn Res Ctr Monitorin, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Yuxing Tan] K;Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, College of Hunan Province, Hunan Provincial Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of XiangJiang River, College of Chemistry and Materials Science, Hengyang Normal University , Hengyang, Hunan 421008, China
关键词：
DNA interaction study;anticancer activity;apoptosis;crystal structure;organotin derivative;synthesis
摘要：
Fourteen new organotin(IV) complexes were successfully synthesized and characterized by elemental analyses, Fourier transform infrared spectroscopy (FT-IR), multinuclear (1H, 13C, and 119Sn) NMR spectroscopy, high-resolution mass spectrometry (HRMS), and X-ray single-crystal techniques. Crystallographic data showed that the complexes 1b, 2b, 3b, and 5b were macrocyclic compounds, 4b exhibited a one-dimensional spiral chain structure with distorted trigonal bipyramidal geometry, other complexes were centrosymmetric dimers, and there was an Sn2O2 four-membered ring in the middle of the molecule. In-vitro anticancer activity against the three human tumor cell lines NCI-H460, MCF-7, and HepG2 was studied, and the dibutyltin complex 5a is a more potent antitumor agent than other complexes and cisplatin. Cell apoptosis study of 5a with the highest activity on HepG2 cancer cell lines was done by flow cytometry; it was shown that the antitumor activity of 5a was related to apoptosis, and it inhibited proliferation by blocking cells in the G2/M phase. The single-cell gel electrophoresis assay results show that 5a induces DNA damage. 5a interacts with ct-DNA by intercalating the mode of interaction. UV–visible absorption spectrometry, fluorescence competitive, viscosity measurements, and gel electrophoresis results also support the intercalative mode of interaction for 5a with DNA.
Fourteen organotin(IV) complexes were synthesized by one-pot microwave irradiation. The complex 5a exhibited high activity and selectivity for inhibiting the HepG2 cell line. And it causes DNA damage and induces cell cycle arrest at G2/M phase and apoptosis.
作者：
Yang Ying-Qun*;Li Chang-Hong;Li Wei;Yang Tian-Yi
期刊：
Chinese Journal of Structural Chemistry,2022年41(3):248-252 ISSN：0254-5861
通讯作者：
Yang Ying-Qun;Li, W;Li, CH
作者机构：
[Li Wei; Yang Ying-Qun] Hunan Prov Coll, Key Lab Funct Met Organ Cpds Hunan Prov, Hengyang 421008, Peoples R China.;[Li Wei; Yang Ying-Qun] Hunan Prov Coll, Key Lab Funct Organomet Mat, Hengyang 421008, Peoples R China.;[Yang Tian-Yi; Li Wei; Yang Ying-Qun] Hengyang Normal Univ, Dept Chem & Mat Sci, Hengyang 421008, Peoples R China.;[Li Chang-Hong; Li, CH] Hunan Inst Technol, Sch Mat & Chem Engn, Hengyang 421002, Peoples R China.
通讯机构：
[Li, W ; Yang, YQ; Li, CH ] H;Hunan Prov Coll, Key Lab Funct Met Organ Cpds Hunan Prov, Hengyang 421008, Peoples R China.;Hunan Prov Coll, Key Lab Funct Organomet Mat, Hengyang 421008, Peoples R China.;Hengyang Normal Univ, Dept Chem & Mat Sci, Hengyang 421008, Peoples R China.;Hunan Inst Technol, Sch Mat & Chem Engn, Hengyang 421002, Peoples R China.
关键词：
europium(III) complex;crystal structure;magnetic and fluorescent properties
摘要：
A new europium（III） complex [Eu2(C14H9O3)6（2，2’-bipy）2]·（2，2’-bipy）2 has been synthesized with 2-benzoylbenzoic acid and 2，2’-bipyridine as ligands. Crystal data: triclinic， space group P1， with a = 13.5251（5）， b = 13.9453（5）， c = 15.3582（5） ?， α = 76.922（3）o， β = 79.740（3）o， γ = 64.248（4）o， V = 2530.83（18） ?3， Dc = 1.496 g/cm3， Z = 1， μ（MoKα） = 1.305 mm-1， F（000） = 1156， the final R = 0.0340 and wR = 0.0638. The Eu（III） ion is coordinated by eight atoms to give a distorted square antiprism coordination geometry. The complex exhibits antiferromagnetism in the temperature range of 300～2 K， and two intense fluorescence emission bands arising from the transitions of Eu3+: 5D0 → 7F1 （595 nm） and 5D0 → 7F2 （618 nm）， respectively. In addition， the fluorescence sensing properties of the complex in CrO42- solution were studied.
期刊：
Journal of Physical Chemistry Letters,2022年13(48):11118-11127 ISSN：1948-7185
通讯作者：
Dong Qian<&wdkj&>Junhua Li<&wdkj&>Jinlong Liu
作者机构：
[Liu, Jinlong; Luo, Ziyu; Li, Jie; Su, Kanda; Zhang, Xinxin; Chen, Xiangxiong; Qian, Dong; Wang, Bowen] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China.;[Li, Junhua] Hengyang Normal Univ, Coll Chem & Mat Sci, Hengyang 421008, Peoples R China.
通讯机构：
[Dong Qian; Junhua Li; Jinlong Liu] C;College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China<&wdkj&>College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, China
摘要：
Herein, an extremely simple l-alanine-assisted pyrolysis method was proposed for the construction of a novel hierarchically porous hybrid of Fe(4)N-Fe supported on N-doped carbon nanobelts and Ketjen black carbon (denoted as Fe(4)N-Fe@N-C/N-KB). It has been found that the participation of l-alanine in pyrolysis can dramatically increase the total pyridinic-N/graphitic-N content in Fe(4)N-Fe@N-C/N-KB, which is peculiarly conducive to the enhancement of ORR performance. The in-site formation of the Fe(4)N-Fe heterojunction via the thermal reduction and decomposition of Fe(3)N as well as the introduction of cheap KB can significantly improve the ORR performance. As a result, the activity, durability, and methanol tolerance of this hybrid are comprehensively better than those of commercial 20 wt % Pt/C, promising future applications in practical devices. Density functional theory calculations disclose that the highly improved ORR activity of Fe(4)N-Fe@N-C/N-KB also benefits from the favorable electron penetration and excellent electronic conductivity between the Fe(4)N nanoparticles and the N-incorporated carbon frameworks.
摘要：
The abnormal accumulation of copper ions (Cu(2+)) is considered to be one of the pathological factors of Alzheimer's disease (AD), but the internal relationship between Cu(2+) and AD progression is still not fully clear. In this work, a sensitive and selective near-infrared fluorescent copper ion probe (DDP-Cu) was designed for quantification and visualization of Cu(2+) level in lysates, living cells, living zebrafish and brain tissues of drosophila and mice with AD. By using this probe, we demonstrated that the content of Cu(2+) in the brains of AD mice and drosophila enhanced nearly 3.5-fold and 4-fold than that of normal mice and drosophila, respectively. More importantly, pathogenesis analysis revealed that elevated Cu(2+) led to changes in factors closely associated with AD, such as the increasing of reactive oxygen species(ROS), the aggregation of amyloid-β protein (Aβ) and nerve cell cytotoxicity. These findings could promote the understanding of the roles between Cu(2+) and AD.
作者机构：
[Lin, Jianguo; Mei, Fangsheng] Xiangtan Univ, Sch Mat Sci & Engn, Xiangtan 411105, Peoples R China.;[Zhang, Zhijian] Hengyang Normal Univ, Coll Chem & Mat Sci, Hengyang 421001, Hunan, Peoples R China.;[Yu, Yang; Gao, Jiangxiong; Lin, Xiaoliang] Zhuzhou Huarui Precis Cutting Tools Co Ltd, Zhuzhou 412000, Peoples R China.;[Yuan, Tiechui] Cent South Univ, Powder Met Res Inst, Changsha 410083, Peoples R China.
通讯机构：
[Fangsheng Mei] S;[Zhang Zhijian] C;School of Materials Science and Engineering, Xiangtan University, Xiangtan, 411105, PR China<&wdkj&>College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan, 421001, PR China
作者：
Sheng, Liang-Bing;Xiao, Hong-Bo;Chen, Man-Sheng;Cheng, Lei
期刊：
Journal of Cluster Science,2022年33(4):1721-1725 ISSN：1040-7278
通讯作者：
Liang-Bing Sheng<&wdkj&>Lei Cheng
作者机构：
[Xiao, Hong-Bo; Sheng, Liang-Bing; Chen, Man-Sheng] Hengyang Normal Univ, Hunan Prov Univ Key Lab Funct Organometall Mat, Coll Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.;[Cheng, Lei] Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Sch Pharm & Chem, Guilin 541004, Peoples R China.
通讯机构：
[Liang-Bing Sheng] H;[Lei Cheng] S;Hunan Province, Hunan Province Universities Key Laboratory of Functional Organometallic Materials, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan, People’s Republic of China<&wdkj&>State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Pharmacy of Guangxi Normal University, Guilin, People’s Republic of China
摘要：
In this work, we report a tetranuclear Co-4 cluster, namely [Co-4(L)(2)(mu(2)-OCH3)(2)(mu(3)-OCH3)(2)(CH3OH)(2)]center dot 2CH(3)OH (1, H2L = 2-{[(2-hydroxy-3-methoxyphenyl)methylidene]amino}benzoic acid). The complex was synthesized and characterized by IR, elemental analysis, thermogravimetric analysis and single crystal X-ray diffraction. X-ray crystallography reveals that complex belongs to the monoclinic crystal system, space group P2(1)/n. Further, their fluorescence and magnetic properties are also discussed. The variable temperature magnetic susceptibilities for complex indicate the existence of antiferromagnetic exchange interactions.
作者机构：
[Cao, Na; Ou, Ya-Ping; Jiang, Penghui; Zhu, Xiaoming; Zhang, Fuxing] Hengyang Normal Univ, Coll Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.;[Cao, Na; Ou, Ya-Ping; Jiang, Penghui; Zhu, Xiaoming; Zhang, Fuxing] Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Hengyang 421008, Peoples R China.;[Cao, Na; Ou, Ya-Ping; Jiang, Penghui; Zhu, Xiaoming; Zhang, Fuxing] Hengyang Normal Univ, Key Lab Funct Organomet Mat, Hunan Prov Coll, Hengyang 421008, Hunan, Peoples R China.;[Cao, Na; Ou, Ya-Ping; Jiang, Penghui; Zhu, Xiaoming; Zhang, Fuxing] Hunan Engn Res Ctr Monitoring & Treatment Heavy M, Hengyang 421001, Hunan, Peoples R China.;[Liu, Sheng Hua; Yang, Xiaofei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Sheng Hua Liu] K;[Ya-Ping Ou] C;Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China<&wdkj&>College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, PR China<&wdkj&>Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Hengyang Normal University, Hengyang 421008, PR China<&wdkj&>Key Laboratory of Functional Organometallic Materials of Hunan Province College, Hengyang Normal University, Hengyang, Hunan 421008, PR China<&wdkj&>Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the upper Reaches of Xiangjiang River, Hengyang, Hunan 421001, PR China
期刊：
Russian Journal of General Chemistry,2022年92(6):1076-1084 ISSN：1070-3632
通讯作者：
Yuxing Tan
作者机构：
[Jiang, Wujiu; Huang, Ping; Tan, Yuxing; Feng, Yunyun; Zhou, Pengfei] Hengyang Normal Univ, Univ Hunan Prov, Coll Chem & Mat Sci, Key Lab Funct Organometall Mat,Hunan Prov Engn Re, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Yuxing Tan] K;Key Laboratory of Functional Organometallic Materials, University of Hunan Province, Hunan Provincial Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of XiangJiang River, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan, China
期刊：
Russian Journal of General Chemistry,2022年92(5):908-913 ISSN：1070-3632
通讯作者：
Wujiu Jiang<&wdkj&>Yuxing Tan
作者机构：
[Jiang, Wujiu; Li, Aodian; Tan, Yuxing; Qin, Qiqi; Feng, Yunyun; Wang, Tiantian] Hengyang Normal Univ, Key Lab Funct Metal Organ Cpds Hunan Prov, Key Lab Organometall New Mat Hunan Prov Engn Res, Coll Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Wujiu Jiang; Yuxing Tan] K;Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, Hunan Provincial Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of XiangJiang River, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan, China<&wdkj&>Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, Hunan Provincial Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of XiangJiang River, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan, China
摘要：
Dibutyltin benzoin benzoyl hydrazone complex I [C6H5(O)C=N-N=C(Ph)CH(Ph)O](2)[(n-Bu)(2)Sn](2) and dibutyltin benzoin salicyl hydrazone complex II [2-(OH)-C6H4(O)C=N-N=C(Ph)CH(Ph)O](2)[(n-Bu)(2)Sn](2) were synthesized and characterized by IR, H-1, C-13 and Sn-119 NMR spectra, FIRMS, elemental analysis and thermal stability analysis, and the crystal structures were determined by X-ray diffraction. The crystal of complex I belongs to monoclinic system, space group P2(1)/n with a = 11.1942(8), b = 10.4754(7), c = 23.6700(17) angstrom, beta = 101.529(2)degrees, Z = 2, V = 2719.6(3) angstrom(3), D-c = 1.371 Mg.m(-3), mu(MoK alpha) = 0.966 mm(-1), F(000) = 1152, R = 0.0458 and wR = 0.1312. The crystal of complex II is of triclinic system, space group P-(1) over bar with a = 9.9960(4), b = 11.2466(4), c = 14.0509(5) angstrom, alpha = 69.4190(10)degrees, beta = 70.0600(10)degrees, gamma = 81.8090(10)degrees, Z = 1, V = 1389.69(9) angstrom(3), D-c = 1.380 Mg.m(-3), mu(MoK alpha) = 0.950 mm(-1), F(000) = 592, R = 0.0284 and wR = 0.0690. In vitro antitumor activities of both complexes were evaluated by CCK8 method against three human cancer cell lines (MCF7, NCI-H460 and HepG2), and complex II exhibited better antitumor activity than I. The interaction between complexes and calf thymus DNA was studied by UV-vis, fluorescence spectroscopy and viscosity measurements.
