通讯机构：
[Tang, LW ] H;Hengyang Normal Univ, Sch Comp Sci & Technol, Hengyang, Peoples R China.;Hunan Prov Key Lab Intelligent Informat Proc & Ap, Hengyang, Peoples R China.
摘要：
The energy epsilon(G) of a graph G is the sum of the absolute values of all eigenvalues of G. Two graphs of the same order are said to be equienergetic if their energies are equal. As pointed out by Gutman, it is not known how to systematically construct any pair of equienergetic, non-cospectral trees until now. Inspired by the research of integral trees, we proposed a construction of infinite pairs of equienergetic trees of diameter 4.
期刊：
Computational Methods and Function Theory,2024年24(1):229-239 ISSN：1617-9447
通讯作者：
Ponnusamy, S
作者机构：
[Li, Liulan] Hengyang Normal Univ, Coll Math & Stat, Hunan Prov Key Lab Intelligent Informat Proc & App, Hengyang 421002, Hunan, Peoples R China.;[Ponnusamy, S; Ponnusamy, Saminathan] Indian Inst Technol Madras, Dept Math, Chennai 600036, India.;[Ponnusamy, S; Ponnusamy, Saminathan] Lomonosov Moscow State Univ, Moscow Ctr Fundamental & Appl Math, Moscow, Russia.;[Wirths, Karl-Joachim] Tech Univ Carolo Wilhelmina Braunschweig, Inst Algebra & Anal, D-38106 Braunschweig, Germany.
通讯机构：
[Ponnusamy, S ] I;Indian Inst Technol Madras, Dept Math, Chennai 600036, India.;Lomonosov Moscow State Univ, Moscow Ctr Fundamental & Appl Math, Moscow, Russia.
关键词：
Meromorphic functions;Taylor coefficients;Laurent series
摘要：
In this article, we consider the family of functions f meromorphic in the unit disk
$${\mathbb D}=\{z:\,|z| < 1\}$$
with a pole at the point
$$z=p$$
, a Taylor expansion
$$\begin{aligned} f(z)= z+\sum _{k=2}^{\infty } a_kz^k, \quad |z|<p, \end{aligned}$$
and satisfying the condition
$$\begin{aligned} \left| \left( \frac{z}{f(z)}\right) -z\left( \frac{z}{f(z)}\right) '-1\right| <\lambda \qquad \text {for all }z\in {\mathbb D}, \end{aligned}$$
for some
$$\lambda $$
,
$$0<\lambda < 1$$
. We denote this class by
$$\mathcal {U}_p(\lambda )$$
and we shall prove a representation theorem for the functions in this class. As consequences, we get a simple proof for the estimates of
$$|a_2|$$
and obtain inequalities for the initial coefficients of the Laurent series of
$$f\in \mathcal {U}_p(\lambda )$$
at its pole. In [8] it had been conjectured that for
$$f\in \mathcal {U}_p(\lambda )$$
the inequalities
$$\begin{aligned} |a_n|\le \frac{1}{p^{n-1}}\sum _{k=0}^{n-1}(\lambda p^2)^k, \quad n\ge 2, \end{aligned}$$
are valid. We provide a counterexample to this conjecture for the case
$$n=3$$
.
摘要：
Metal single-atom catalysts offer the dual advantages of high electrochemical activity and near 100 % metal atom utilization, leading to their potential use in low-cost electrochemical sensor development. Herein, a novel electrocatalyst comprising atomically-dispersed Mn on B,N co-doped bamboo-derived carbon (MnSAs-BN-BC) was synthesized via a facile pyrolysis procedure. A high dispersion of Mn single atoms in MnSAs-BN-BC was confirmed by aberration-corrected transmission electron microscopy and elemental mapping. The Mn loading in the MnSAs-BN-BC determined by inductively coupled plasma mass spectrometry was 255 mg kg-1. MnSAs-BNBC displayed outstanding electrocatalytic performance for levodopa (LD) oxidation, allowing a robust electrochemical sensing platform for LD detection to be established. The MnSAs-BN-BC/GCE sensing platform offered a wide LD detection range (concentrations from 2 to 683 mu M) and a very low limit of detection (LOD) of 0.45 mu M, outperforming almost all electrochemical sensors reported to date for LD sensing. The MnSAs-BN-BC/GCE platform also featured outstanding repeatability, reproducibility, selectivity, and stability. The as-developed sensing platform was successfully applied to LD quantification in commercial tablets with satisfactory recoveries (85.2-102.4 %), with the analytical precision of method validated against a traditional UV-vis spectrophotometry method. Density functional theory (DFT) calculations showed that Mn single atom sites lowered the reaction energy barrier for LD oxidation, with the favorable d-band center position of Mn single atom sites in MnSAs-BN-BC contributing to the enhanced LD sensing performance. This work encourages the use of singleatom metal catalysts in design of high-performance electrochemical sensors for the rapid detection of LD.
作者机构：
[Liu, Qin; He, Yingjian; Liu, Jinlong; Qian, Dong; Chen, Xiangxiong; Wang, Bowen; Luo, Ziyu; Liu, JL; Zhang, Xinxin] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China.;[Chen, Xiangxiong] Yoening Tianci Min Changsha Technol Ctr, Changsha 410083, Peoples R China.;[V. Kennedy, John] GNS Sci, Natl Isotope Ctr, POB 30368, Lower Hutt 5010, New Zealand.;[Li, Junhua] Hengyang Normal Univ, Coll Chem & Mat Sci, Hengyang 421008, Peoples R China.;[Waterhouse, Geoffrey I. N.; Waterhouse, GIN] Univ Auckland, Sch Chem Sci, Auckland 1142, New Zealand.
通讯机构：
[Qian, D; Liu, JL ] C;[Waterhouse, GIN ] U;Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China.;Univ Auckland, Sch Chem Sci, Auckland 1142, New Zealand.
关键词：
Electrochemical reconstruction;CoMoO4-based catalyst;Phosphorization;Heterojunction;Overall water splitting
摘要：
Phosphorization of molybdates has been shown to promote hydrogen evolution reaction (HER) activity but is usually detrimental to oxygen evolution reaction (OER) activity, frustrating efforts to create bifunctional HER/OER electrocatalysts. Herein, we show that Fe2O3-modulated P-doped CoMoO4 on nickel foam (Fe-P-CMO) is an excellent bifunctional HER/OER electrocatalyst in alkaline media, with the adverse effect of phosphorization on the OER activity of CoMoO4 being countered via Fe2O3 introduction. An alkaline splitting electrolyser assembled directly using the self-supporting Fe-P-CMO electrode possessed outstanding long-term durability with ultralow cell voltages of 1.48 and 1.59 V required to achieve current densities of 10 and 100 mA cm−2, respectively. Detailed experimental investigations showed that during HER, P-doped CoMoO4 in Fe-P-CMO underwent surface reconstruction with the in-situ formation of Co(OH)2 on the P-CoMoO4 (Co(OH)2/P-CoMoO4). During OER, P-doped CoMoO4 was deeply reconstructed to CoOOH with the complete dissolution of Mo, leading to the in-situ formation of Fe2O3/CoOOH heterojunctions.
通讯机构：
[Zhong, C ] H;Hengyang Normal Univ, Coll Comp Sci & Technol, Hengyang 421002, Hunan, Peoples R China.;Hunan Prov Key Lab Intelligent Informat Proc & App, Hengyang 421002, Hunan, Peoples R China.
关键词：
Image encryption;Chaotic map;Variable key space;Key association
摘要：
The security of images is of great importance given the current development of Internet technology. The existing encryption algorithms have some defects, such as the key space is not large enough and the encryption speed is slow. A fast image encryption algorithm with variable key space is proposed. The algorithm key space is dynamically changeable and the variable key space is associated with the initial condition of Hénon map, making this cryptosystem extremely sensitive to the key. The overall algorithm uses a permutation-diffusion-permutation-diffusion encryption structure. The first permutation process is implemented by cross-sampling and the first diffusion is implemented by modal operation. The second permutation is implemented using the chaotic sequence approach and the second diffusion is implemented using the XOR operation. The designed permutation and diffusion operations are executed with high efficiency, and the two different diffusion operations make the encryption process with nonlinear mapping capability, making the algorithm effective against existing typical differential attack schemes. Experiments show that the algorithm has a dynamically adjustable key space, high efficiency of algorithm encryption, good robustness, and effective resistance to statistical attack analysis and differential attack analysis.
期刊：
Frontiers in Public Health,2024年12:1288262 ISSN：2296-2565
通讯作者：
Yin, L
作者机构：
[Li, Fang; Luo, Wanhong] Hunan First Normal Univ, Sch Phys Educ, Changsha, Peoples R China.;[Yin, Long; Yin, L] Hunan Normal Univ, Coll Phys Educ, Changsha, Peoples R China.;[Gao, Zan] Univ Tennessee, Dept Kinesiol Recreat & Sport Studies, Knoxville, TN USA.;[Ryu, Suryeon] Univ Minnesota Twin Cities, Sch Kinesiol, Minneapolis, MN USA.;[Sun, Mingyun] Hengyang Normal Univ, Sch Math & Stat, Hengyang, Peoples R China.
通讯机构：
[Yin, L ] H;Hunan Normal Univ, Coll Phys Educ, Changsha, Peoples R China.
关键词：
24-h movement behavior;isotemporal substitution;mental health;non-screen-based sedentary behavior;screen-based sedentary behavior
摘要：
The 24-h movement behavior of preschoolers comprises a spectrum of activities, including moderate-to-vigorous intensity physical activity (MVPA), light-intensity physical activity (LPA), screen-based sedentary behavior (SCSB), non-screen-based sedentary behavior (NSCSB), and sleep. While previous research has shed light on the link between movement behaviors and children's mental health, the specific impacts on the unique demographic of Chinese preschoolers remain underexplored. This study significantly contributes to the literature by exploring how 24-h movement behavior affects the mental health of preschoolers in a Chinese context. The study involved205 Chinese preschool children (117 boys and 88 girls) between the ages of 3 and 6 years wore accelerometers to measure their LPA, MVPA, and sedentary behavior (SB), while their parents reported the time spent on sleep and SCSB. The parents also completed the Strength and Difficulties Questionnaire to assess their children's mental health. The study used compositional regression and isotemporal substitution models to examine the relationship between the various components of 24-h movement behavior and mental health. The results showed that greater NCSSB compared to MVPA, LPA, sleep, and SCSB was associated with good prosocial behavior and lower scores on externalizing problems. This highlights the potential of NSCSB as a beneficial component in the daily routine of preschoolers for fostering mental well-being. Replacing 15 min of sleep and SCSB with 15 min of NSCSB was associated with a decrease of 0.24 and 0.15 units, respectively, in externalizing problems. Reallocating 15 min of sleep to NSCSB was linked to an increase of 0.11 units in prosocial behavior. There were no significant substitution effects between LPA and MVPA time with any other movement behavior on prosocial behavior and externalizing problems. Given the positive associations observed, further longitudinal studies are necessary to explore the link between 24-h movement behavior and mental health in preschool children.
期刊：
Journal of Hydrology: Regional Studies,2024年52:101690 ISSN：2214-5818
通讯作者：
Zhang, XP
作者机构：
[Xiao, Xiong; Rao, Zhiguo; Li, Jiajie; Zhang, Xinping; Dai, Junjie; He, Xinguang; Zhang, Cicheng] Hunan Normal Univ, Coll Geog Sci, Changsha, Peoples R China.;[Xiao, Xiong; He, Xinguang; Zhang, Xinping] Hunan Normal Univ, Key Lab Geospatial Big Data Min & Applicat Hunan P, Changsha, Peoples R China.;[Liu, Na] Hengyang Normal Univ, Coll Geog & Tourism, Hengyang, Hunan, Peoples R China.
通讯机构：
[Zhang, XP ] H;Hunan Normal Univ, Coll Geog Sci, Changsha, Peoples R China.
关键词：
Stable isotopes;Seasonal origin index;Xylem water;Leaf water;Soil water
摘要：
Study region: From 2017 to 2019, xylem and leaf samples of Cinnamomum camphora were sampled and soil water samples at 0-100 cm depth were sampled 65 times simultaneously in a typical East Asian monsoon region. Study focus: The seasonal origin of plant and soil water from precipitation was inferred based on the stable isotope techniques, including the evaporation line slope (SEL) estimations and the seasonal origin index (SOI) calculation. New hydrological insights for the region: The regression SEL of leaf water was close to the theoretical SELs estimated based on the Craig-Gordon model, but xylem water and soil water showed higher regression SELs than the theoretical SELs, this may be due to the seasonality of the precipitation isotopes and evaporative fractionation. The fractionation-compensated isotopic values calculated based on the theoretical SELs of different water types were close, with the differences within 2.4%o for 618O and 20.0%o for 62H of each other, and the uncertainty of the fractionationcompensated isotopic values was low enough in the calculation of SOI. The SOI results showed that summer precipitation was more prevalent in plant and soil water, and more winter precipitation may recharge runoff when evapotranspiration demand is weak. Overall, the leaf sampling and the theoretical method have the potential to infer the seasonal water origin over a relatively long period.
摘要：
This study aimed to investigate the effects of fermented tofu processing wastewater (FTPW) on the growth performance and meat quality of Xianghuang broilers. A total of 160 six-week-old Xianghuang broilers were randomly assigned to control or FTPW groups with eight replicate pens of 10 birds each pen. Broilers received the same corn-soybean diet but different water. Broilers received ordinary water in the control group and 40% (volume: volume) FTPW (the solution has been filtered with four layers of sieve, containing Bacillus 1.52 × 10(-7) CFU/mL) in FTPW group. The experiment lasted for 30 days. Results indicated that growth performance was not affected by treatment (p > 0.05). The value of pH(45 min) and a(48 h) increased and drip loss(72 h) and toughness decreased in breast muscle when broilers received FTPW solution compared with the control group (p < 0.05). The pH(45 min), a(45 min), a(48 h) value and crude fat concentration of thigh muscle were higher in FTPW group than that in control group (p < 0.05). Compared with control group, fibre area decreased but fibre density increased in thigh muscle when Xianghuang chickens supplemented with FTPW solution (p < 0.05). Supplementation of FTPW solution in drinking water significantly decreased malondialdehyde content in the breast muscle of Xianghuang chickens (p < 0.05). Gene expressions such as carnitine palmitoyltransferase 1A (CPT1) and glycogen synthase of breast muscle were downregulated in experimental group when compared with control group. In conclusion, FTPW supplementation in drinking water could improve meat quality of Xianghuang broilers by regulating pH value, redness and fibre morphology.
期刊：
FRONTIERS IN PEDIATRICS,2024年12:1337158 ISSN：2296-2360
通讯作者：
Li, F;Liu, P
作者机构：
[Yin, Long] Hunan Normal Univ, Coll Phys Educ, Changsha, Peoples R China.;[Li, Fang; Li, F] Hunan First Normal Univ, Sch Phys Educ, Changsha, Peoples R China.;[Liu, Pan] Hunan Univ Technol, Sch Phys Educ, Zhuzhou, Peoples R China.;[Yin, Zhiqiang] Hengyang First High Sch, English Course Grp, Hengyang, Peoples R China.;[Yang, Zongyu] Guangxi Univ Nationalities, Sch Phys Educ & Hlth Sci, Nanning, Peoples R China.
通讯机构：
[Li, F ; Liu, P ] H;Hunan First Normal Univ, Sch Phys Educ, Changsha, Peoples R China.;Hunan Univ Technol, Sch Phys Educ, Zhuzhou, Peoples R China.
摘要：
BACKGROUND: Limited research has explored the relationship between adhering to 24-h Movement Behaviour guidelines and mental health in Chinese preschool children. The objectives of this study encompassed two primary goals: (1) to investigate the adherence of preschool children in China to the 24-h Movement Behaviour guidelines; and (2) to analyze the relationship between fulfilling various combinations of these guidelines and mental health, identifying the most advantageous combination. METHODS: Utilizing a convenience sampling approach, this study included 205 preschool children (117 boys and 88 girls, average age 4.8 ± 0.51 years) from five kindergartens in Hengyang, Hunan Province. The physical activity (PA) and sedentary behaviour of preschool children were objectively assessed using waist-worn accelerometers, while sleep duration and screen time were reported by the children's parents. To evaluate mental health, the parent version of the internationally validated Strength and Difficulties Questionnaire (SDQ) was employed, which measures externalizing problems, internalizing problems, and prosocial behaviour. Employing Mplus 8.0 for Structural Equation Modeling analysis, while controlling for demographic variables, the study explored the connection between preschool children's mental health and their adherence to the 24-h Movement Behaviour guidelines. RESULTS: Worryingly, merely 14.6% of preschoolers met the recommended guidelines for all three aspects (PA, sleep duration, and screen time). Positive correlations were identified between meeting PA guidelines and displaying prosocial behaviour (β = 0.184; p < 0.05), while screen time adherence exhibited a negative correlation with externalizing problems (β = -0.207; p < 0.05). Similarly, there was a negative association between sleep duration adherence and externalizing problems (β = -0.191; p < 0.05). Meeting all three recommended guidelines was notably linked to enhanced prosocial behaviour (β = 0.464; p < 0.05), while following the screen time and sleep duration guidelines was negatively associated with externalizing problems (β = -0.246; p < 0.05). CONCLUSION: This study underscores the limited adherence of Chinese preschoolers to the comprehensive 24-h Movement Behaviour guidelines. Noteworthy findings include the positive influence of PA on prosocial behaviour, alongside the significant roles that sleep duration and screen time play in mitigating externalizing problems within this age group. Alignment with the 24-h Movement Behaviour guidelines is associated with more favorable mental health indicators in preschoolers.
关键词：
Photonic spin Hall effect;Transverse beam shift;Tuning range;Insulating-metallic phase transition
摘要：
The photonic spin Hall effect (PSHE) can manifest as the spin-dependent splitting (perpendicular to the plane of incidence) of a light beam, i.e., transverse beam shift. Introducing dynamically tunable PSHE into post-fabricated systems has great potential for the new type of photonic devices and its tuning range can be manipulated with different reconfigurable methods. Most of these methods are based on modifying the refractive index of bulk or interface materials. However, the perturbation on the refractive index is usually small, leading to difficulty in enhancing PSHE. Fortunately, the changes in the refractive index of Vanadium Dioxide (VO2) with insulating-metallic phase transition can be larger in several orders than that of other materials, making it possible for enhancing PSHE to have greater tuning range. Here, to explore the dynamically tunable PSHE based on the insulating-metallic phase transition of VO2, the transverse beam shift (as an indicator of PSHE) was calculated with a full wave theory at a wavelength of 1550 nm in a layered structure. Without a gold layer, only the PSHE of the H-polarized beam shows significant tunability in the insulating-metallic phase transition of VO2. With the Au layer, the PSHE of the H- and V-polarized beam is enhanced around the Brewster and Brewster-like (originating from the destructive interference between the nanosized layers) angle, respectively. For H- and V-polarized beams, the tuning range of PSHE is mainly determined by the insulating phase of VO2 and can be enhanced with the Au layer. Finally, as an example, the enhanced tuning range makes the output of a two-digit binary code conversion based on PSHE easier to recognize. These results offer us possible ways to control the tuning range of PSHE in post-fabricated systems and provide more potential for new applications.
通讯机构：
[Feng, C ] H;Hengyang Normal Univ, Coll Geog & Tourism, Hengyang 421002, Peoples R China.
关键词：
Event-based extreme precipitation;Time distribution pattern;Contribution rate of urbanization;Xiangjiang River Basin
摘要：
An in-depth understanding of event-based extreme precipitation (EEP), emphasizing precipitation process, can help to prevent the risk posed by regional high-intensity and persistent precipitation. The concept of time distribution pattern (TDP) is used to distinguish EEPs, which classifies EEPs according to the occurrence time of extreme precipitation. Furthermore, TDP1,2,3 is that the distribution of daily precipitation above the threshold is in the first half, in the second half, and both the first half and second half of EEP, respectively. We analyze temporal characteristics, spatial distribution, future trends of EEP, and the contribution rate of urbanization to EEP in this study. EEP thresholds exhibit a latitudinal gradient from central to northern and southern regions except for Nanyue Station (NY). TDP1 and TDP2 account for more than 60% among the total of EEPs. However, TDP3 is the dominant precipitation type observed at each station from the perspective of precipitation, intensity, duration, especially, in summer. EEP is less and TDP is unstable in autumn and winter. In general, there is an increasing trend in EEP and it is predicted that the trend of EEP will continue to rise. Moreover, the contribution rate of urbanization to EEP varies significantly, with a more pronounced inhibitory effect observed. The inhibitory effect of urbanization on the frequency and duration of TDP3 reached 60.83% and 72.77%, respectively. However, it is more significant on the extreme nature of TDP1 under urbanization, with a positive contribution rate of 9.63% and 21.83% to precipitation and intensity of TDP1, respectively. The results conclude that the higher the level of urbanization, the more pronounced the extreme trend of TDP1 becomes.
摘要：
The massive collection and transmission of various crop and livestock data in smart agriculture leads to serious security concerns. Furthermore, many Internet of Things (IoT) devices in smart agriculture are battery-powered, with limited energy resources. Therefore, a low energy lightweight block cipher (LELBC) is proposed to overcome the data leakage problem during sensor data transmission in smart agriculture. Firstly, a new permutation substitution permuta-tion (PSP) structure is proposed, taking into account the energy resource constraints of unified encryption and decryption (ED) circuits. It has highly consistent encryption and decryption and a good diffusion effect. Secondly, a 4-bit low energy involutive S-box is obtained based on a genetic algorithm. The proposed S-box has lower area and latency compared to the existing S-boxes. The experimental data show that LELBC consumes 1864 gate equivalents (GE) in area and 6.99 mu J/bit in energy (encryption + decryption) under the UMC 0.18 mu m 1P6M process library. LELBC decreases energy and area consumption by 24.02% and 24.04%, respectively, compared to Midori. Finally, a temperature collection and encryption transmission platform is established. LELBC is deployed on the platform to encrypt the collected data, establishing the first line of defense for the secure transmission of smart agriculture sensor data.
通讯机构：
[Tang, ZK ] U;Univ Hunan Prov, Key Lab Micronano Energy Mat & Applicat Technol, Hengyang 421002, Peoples R China.
摘要：
Two-dimensional material-supported single metal atom catalysts have been extensively studied and proved effective in electrocatalytic reactions in recent years. In this work, we systematically investigate the OER catalytic properties of single metal atoms supported by the NiN(2) monolayer. Several typical transition metals with high single atom catalytic activity, such as Fe, Co, Ru, Rh, Pd, Ir, and Pt, were selected as catalytic active sites. The energy calculations show that transition metal atoms (Fe, Co, Ru, Rh, Pd, Ir, and Pt) are easily embedded in the NiN(2) monolayer with Ni vacancies due to the negative binding energy. The calculated OER overpotentials of Fe, Co, Ru, Rh, Pd, Ir and Pt embedded NiN(2) monolayers are 0.92 V, 0.47 V, 1.13 V, 0.66 V, 1.25 V, 0.28 V, and 0.94 V, respectively. Compared to the 0.57 V OER overpotential of typical OER noble metal catalysts IrO(2), Co@NiN(2) and Ir@NiN(2) exhibit high OER catalytic activity due to lower overpotential, especially for Ir@NiN(2). The high catalytic activity of the Ir embedded NiN(2) monolayer can be explained well by the d-band center model. It is found that the adsorption strength of the embedded TM atoms with intermediates follows a linear relationship with their d-band centers. Besides, the overpotential of the Ir embedded NiN(2) monolayer can be further reduced to 0.24 V under -2% biaxial strain. Such findings are expected to be employed in more two-dimensional material-supported single metal atom catalyzed reactions.
作者机构：
[Liu, Qian-Wen; Yu, Hong; Liu, Xin-Yun; Yang, Qin-Xin] Department of Pathology, The Affiliated Taizhou People's Hospital of Nanjing Medical University,Taizhou,Jiangsu Province 225300,China;[Liu, Qian-Wen] General Surgery, Institute of Pancreatic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;[Yang, Zhi-Wen] Department of Pharmacy, Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai,Shanghai 200050,China;[Tang, Qing-Hai] Hunan Key Laboratory for Conservation and Utilization of Biological Resources in the Nanyue Mountainous Region and College of Life Sciences, Hengyang Normal University,Hengyang,Hunan Province 421008,China;[Wang, Wen-Er] General Surgery, the Fourth Hospital Of Changsha, Changsha Hospital Of Hunan Normal University,Changsha,Hunan Province 410006,China
摘要：
Synthetic lethality is a phenomenon wherein the simultaneous deficiency of two or more genes results in cell death, while the deficiency of any individual gene does not lead to cell death. In recent years, synthetic lethality has emerged as a significant topic in the field of targeted cancer therapy, with certain drugs based on this concept exhibiting promising outcomes in clinical trials. Nevertheless, the presence of tumor heterogeneity and the intricate DNA repair mechanisms pose challenges to the effective implementation of synthetic lethality. This review aims to explore the concepts, development, and ethical quandaries surrounding synthetic lethality. Additionally, it will provide an in-depth analysis of the clinical application and underlying mechanism of synthetic lethality.
