摘要：
Lead halide perovskites (LHPs) are very promising for new optoelectronic devices due to their excellent optical and electronic properties. However, the poor stability against water, heat and UV light greatly restricts their practical applications. In this work, a CH3NH3PbBr3/silicon oil/PDMS-urea composite is prepared by encapsulating CH3NH3PbBr3 nanocrystals and silicon oil into the PDMS-urea polymer matrix. This composite shows characteristics of water-enhanced photoluminescence (PL) and water-driven PL recovery. After immersed in water, the photoluminescence quantum yield of the composite increases from initial 26.0%-52.2%, which is ascribed to the passivation of surface defects by the capping of polymer chains, H3O+ and OH-. The composite possesses superior stability against UV light illumination in water. Furthermore, the composite film exhibits a capability of water-driven PL recovery after UV light irradiation. By applying alternate water/UV treatments, the PL can be reversibly switched "on and off". The "on/off" ratio value of the PL intensity reached more than 4. These advantages make this composite highly promising in applications utilising luminescent switching and for under water lighting. (c) 2020 Elsevier B.V. All rights reserved.
作者机构：
[Zhang, Fu-Xing; Sheng, Liang-Bing; Chen, Man-Sheng; Liu, Meng-Qin] Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Hunan Prov Univ Key Lab Funct Organometall Mat, Coll Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Sheng, LB; Chen, MS] H;Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Hunan Prov Univ Key Lab Funct Organometall Mat, Coll Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
关键词：
Electrospray-ionization mass spectrometry;Heteronuclear;Homonuclear;One-dimensional chain;Structure
摘要：
The organic ligand (E)-8-hydroxyquinoline-2-carbaldehyde oxime (H2L) was used to react with Ni(CH3COO)(2)center dot 4H(2)O and NaN(CN)(2) at 100 degrees C to obtain the complex [Ni3Na(HL)(3)(L)(2)](n)center dot 4nCH(3)CN (1). Interestingly, the five ligands in the structure chelate three Ni ions, and the uncoordinated O on the ligand captures one Na+. However, the above scheme remains the same, and after adding isonicotinic acid (ina), it obtained the complex [Ni-4(HL)(4)(L)(2)](2)center dot 2CH(3)CN (2), which eight Ni2+ ions are coordinated by twelve ligands. The component distribution of the complexes in different solutions was measured by electrospray-ionization mass spectrometry (ESI-MS). It was found that the complexes exhibited different component distribution in different solutions. Not only the existence of low-nuclear molecular ion peaks could be monitored, but even higher-nuclear components could also be detected, and the alkali metal ions could be effectively identified. It was indicating that the compounds would assemble differently in different solutions. Surprisingly, homonuclear clusters 2 was providing a basis for further directing the directed synthesis of higher nuclear clusters. (C) 2019 Published by Elsevier Ltd.
作者机构：
[Xiao, Jie; Liu, Yunmei; Yu, Wenmei; Guo, Yu; Zhang, Qizhi; Li, Yang] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.;[He, Jun] Univ South China, Inst Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Liu, Mengqin] Hengyang Normal Univ, Inst Chem & Mat Sci, Hengyang 421001, Peoples R China.
通讯机构：
[Liu, Yunmei; He, Jun] U;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.;Univ South China, Inst Chem & Chem Engn, Hengyang 421001, Peoples R China.
关键词：
Anti-tumor;Drug target;Inhibitors of protein kinases;Quinazoline derivatives;Structure-activity relationship
摘要：
Quinazoline was originally utilized as an anti-tumor treatment, and its various derivatives can be directly extracted from plants. In recent years, protein kinases (PK) have been well recognized in the development of tumor drugs. Functionally, PK serves a vital role in the apoptosis, proliferation, differentiation, migration and cell cycle of tumor cells. Due to its good physicochemical properties, quinazoline skeleton, a superior type of PK inhibitor, has been extensively used in anti-tumor drug design. An increasing number of studies on quinazoline synthesis have been reported and used by different groups to effectively develop novel derivatives. Thus, several studies have been approved for the use of quinazoline derivatives as inhibitors of other kinases, including Src and histone deacetylase. The aim of the present review was to summarize the mechanism of quinazoline compounds as PK inhibitors, their biological structure-activity relationship such as the substituted quinazoline compounds with different functional groups in the apoptotic process, and their effect on the proliferation of tumor cells. The development of novel agents based on the antitumor functions of quinazoline molecular compounds may improve the clinical outcomes of the affected population, particularly in patients with cancer.
摘要：
A nanohybrid composed of Ag@Cu2O heterogeneous nanocrystals supported on N-doped reduced graphene oxide (Ag@Cu2O/N-RGO) has been synthesized by a simple wet-chemical method. The resultant composite consists of N-RGO sheets fully and homogeneously coated with a dense layer of Ag@Cu2O nanocrystals. Both Ag and N-RGO are in direct contact with Cu2O, and Ag nanoparticles with sizes of 2-5 nm are mainly deposited on the surface of Cu2O cubes (edge length of 500 nm). The electrochemical studies reveal that the ternary Ag@Cu2O/N-RGO composite exhibit significantly enhanced electrocatalytic activity for H2O2 sensing compared with either the single component (N-RGO) or two component systems (Cu2O/N-RGO and Ag/N-RGO), which is mainly due to the synergetic catalysis of the ternary system. The nonenzymatic sensor based on Ag@Cu2O/N-RGO composite shows overwhelmingly superior comprehensive performance for the H2O2 detection over the documented Ag-based sensors. More specifically, it displays a rapid response (10 s) to H2O2 over a wide linear range of 54-700 nM with a high sensitivity of 1298.3 mu A mM(-1) cm(-2) and a low detection limit of 10 nM. Moreover, the sensor also exhibits the preferable selectivity in the presence of biologically coactive compounds accompanied with long-term stability and good reproducibility. (C) 2018 Elsevier B.V. All rights reserved.
摘要：
<![CDATA[<ce:abstract xmlns:ce="" xmlns="" xml:lang="en" id="abs0010" view="all" class="author"><ce:section-title id="sectitle0010">Abstract</ce:section-title><ce:abstract-sec id="abssec0010" view="all"><ce:simple-para id="abspara0010" view="all">In this work, the N doping together with Pd?Cu@Cu<ce:inf loc="post">2</ce:inf>O hybridization for graphene oxide was achieved by a combined process of hydrothermal treatment and chemical reduction, based on which a novel Pd?Cu@Cu<ce:inf loc="post">2</ce:inf>O cubes decorated N-doped reduced graphene oxide (Pd?Cu@Cu<ce:inf loc="post">2</ce:inf>O/N-RGO) hybrid was obtained. The synthesized Pd?Cu@Cu<ce:inf loc="post">2</ce:inf>O/N-RGO was detailedly characterized by various technologies. The results show that the low Pd loading Cu@Cu<ce:inf loc="post">2</ce:inf>O cubes with the sizes of 300–500?nm are well dispersed on N-RGO sheets, thereby avoiding the serious aggregation and maintaining a large electroactive surface area of the attained hybrid. Benefiting from the synergistic effect of the properties of Pd?Cu@Cu<ce:inf loc="post">2</ce:inf>O particles and N-RGO sheets, the Pd?Cu@Cu<ce:inf loc="post">2</ce:inf>O/N-RGO modified electrode exhibits remarkable electrocatalytic performance on the oxidation of tryptophan with the enhanced oxidation response and the lowered oxidation overpotential. Under the optimal conditions for the electrochemical detection of tryptophan, the constructed sensor displays a wide linear range (0.01–40.0?μM) and a low detection limit (1.9?nM), outperforming most of the reported hybrid-based sensors. The proposed sensor also features good selectivity, stability and reproducibility, which has been successfully applied for the detection of tryptophan in the urine and milk samples with satisfactory recoveries. All these results suggest that the Pd?Cu@Cu<ce:inf loc="post">2</ce:inf>O/N-RGO hybrid could be a promising and convenient material for the fabrication of high-performance electrochemical sensors.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:abstract xmlns:ce="" xmlns="" class="graphical" id="abs0015" view="all"><ce:section-title id="sectitle0015">Graphical abstract</ce:section-title><ce:abstract-sec id="abssec0015" view="all"><ce:simple-para>Display Omitted</ce:simple-para></ce:abstract-sec></ce:abstract><ce:abstract xmlns:ce="" xmlns="" class="author-highlights" xml:lang="en" id="abs0020" view="all"><ce:section-title id="sectitle0020">Highlights</ce:section-title><ce:abstract-sec id="abssec0020" view="all"><ce:simple-para id="abspara0020" view="all"><ce:list id="ulist0010"><ce:list-item id="u0010"><ce:label>?</ce:label><ce:para id="p0010" view="all">The Pd?Cu@Cu<ce:inf loc="post">2</ce:inf>O/N-RGO hybrid was synthesized via a facile wet chemical route.</ce:para></ce:list-item><ce:list-item id="u0015"><ce:label>?</ce:label><ce:para id="p0015" view="all">An enhanced electrocatalytic property of the hybrid has been demonstrated.</ce:para></ce:list-item><ce:list-item id="u0020"><ce:label>?</ce:label><ce:para id="p0020" view="all">The constructed sensor displays super performances for the tryptophan detection.</ce:para></ce:list-item><ce:list-item id="u0025"><ce:label>?</ce:label><ce:para id="p0025" view="all">Advantages include excellent practicability with remarkable reliability.</ce:para></ce:list-item></ce:list></ce:simple-para></ce:abstract-sec></ce:abstract>]]>
