作者机构：
[Zhang, Fuxing; Qing, Jingjing; Tian, Jie; Deng, Xin] Hengyang Normal Univ, Sch Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.;[Zhang, Fuxing] Hengyang Normal Univ, Mat Sci Hengyang Normal Univ, Coll Hunan Prov,Hunan Prov Key Lab Funct Met Organ, Sch Chem,Key Lab Organometall New Mat, Hengyang 421008, Peoples R China.
通讯机构：
[Zhang, FX ] H;Hengyang Normal Univ, Mat Sci Hengyang Normal Univ, Coll Hunan Prov,Hunan Prov Key Lab Funct Met Organ, Sch Chem,Key Lab Organometall New Mat, Hengyang 421008, Peoples R China.;Hengyang Normal Univ, Sch Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
摘要：
Retigabine is a new type of drug widely used in the treatment of epilepsy and other symptoms. It is mainly used for adjuvant treatment of partial seizures in adults with refractory epilepsy. There are many synthetic processes of retigabine. However, retigabine can cause fatigue, dizziness, vertigo and even neurasthenia and hallucinations during clinical treatment. This article combines the patient's clinical response to develop the synthetic scheme of retigabine. And according to the side effects of adjuvant retigabine treatment. This article summarizes the various synthetic methods of retigabine and studies the new synthetic scheme of retigabine in combination with the clinical response.
摘要：
Two novel bis(2-hydroxy-5-R-benzylidene) carbohydrazide dibutyltin complexes (R: Cl (T1), Me (T2)) with hexanuclear and triangular frame structures were obtained by microwave-assisted solvothermal reaction of dibutyltin oxide precursor with the ligands in methanol environments, However, their structures are characterized by elemental analysis, IR, (H-1, C-13) NMR spectra, and the molecular structures of T1 and T2 were confirmed by X-ray diffraction. The crystal of T1 belongs to triclinic system, space group P (1) over bar, and T2 is of monoclinic system, space group C2/c. Five-coordinated distorted triangular bipyramids and six-coordinated distorted octahedral configurations were formed by the coordination of oxygen and nitrogen atoms of ligands with two dibutyltins, respectively, and trimer hexanuclear dibutyltin complexes were constructed by the cross-coordination of enol imines. The two complexes exhibit fluorescence emission in DMF solvents and DMF-water mixtures. When the volume fraction of water content is between 0 and 10% (V/V), the aggregation fluorescence enhancement effect is good, and fluorescence quenching occurs when the water content is more than 10% (V/V). The T1 can inhibit the growth of target plants, such as Portulaca oleracea, Cassia tora L., Brassica campestris L.ssp.chinensis var.utilis Tsen et Lee and Amaranthus tricolor L. The T2 can selectively inhibit the growth of Portulaca oleracea L., Amaranthus spinosus L. and Amaranthus tricolor L. It can be used as a candidate herbicide for Portulaca oleracea L., Amaranthus spinosus L. and Amaranthus tricolor L.
作者机构：
[Zhang, Fu-Xing; Sheng, Liang-Bing; Chen, Man-Sheng; Liu, Meng-Qin] Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Hunan Prov Univ Key Lab Funct Organometall Mat, Coll Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Sheng, LB; Chen, MS] H;Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Hunan Prov Univ Key Lab Funct Organometall Mat, Coll Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
关键词：
Electrospray-ionization mass spectrometry;Heteronuclear;Homonuclear;One-dimensional chain;Structure
摘要：
The organic ligand (E)-8-hydroxyquinoline-2-carbaldehyde oxime (H2L) was used to react with Ni(CH3COO)(2)center dot 4H(2)O and NaN(CN)(2) at 100 degrees C to obtain the complex [Ni3Na(HL)(3)(L)(2)](n)center dot 4nCH(3)CN (1). Interestingly, the five ligands in the structure chelate three Ni ions, and the uncoordinated O on the ligand captures one Na+. However, the above scheme remains the same, and after adding isonicotinic acid (ina), it obtained the complex [Ni-4(HL)(4)(L)(2)](2)center dot 2CH(3)CN (2), which eight Ni2+ ions are coordinated by twelve ligands. The component distribution of the complexes in different solutions was measured by electrospray-ionization mass spectrometry (ESI-MS). It was found that the complexes exhibited different component distribution in different solutions. Not only the existence of low-nuclear molecular ion peaks could be monitored, but even higher-nuclear components could also be detected, and the alkali metal ions could be effectively identified. It was indicating that the compounds would assemble differently in different solutions. Surprisingly, homonuclear clusters 2 was providing a basis for further directing the directed synthesis of higher nuclear clusters. (C) 2019 Published by Elsevier Ltd.
摘要：
The 1,5-disubstituted thiocarbohydrazide ligands were prepared by the condensation of thiocarbohydrazide with salicylaldehyde and 5-methylsalicylaldehyde, respectively. The butyltin complexes, [(5-R-2-hydroxy)ArCH=NNH](2)CS(n-BuSnCl)(2), R = H(T1); R = Me(T2), based on the 1,5-disubstituted thiocarbohydrazide were obtained by microwave-assisted solvothermal reaction of n-butyltintrichloride precursor with the ligands in methanol environments, which have been structurally characterized by elemental analysis, IR and (H-1,C-13) NMR spectra. The crystals belong to monoclinic system, space groups C2/c(T1) and Pc(T2), respectively. The Sn atom is six-coordinated with distorted octahedral geometry by 0, N and S atoms from ligand, C atom of butyl and two Cl atoms. In the crystal, complex T1 forms three-dimensional supramolecular assembly mediated by noncovalent interactions such as C-H center dot center dot center dot Cl and pi-stacking interactions. Similarly, T2 forms an interesting two-dimensional supramolecular structure by noncovalent interactions (e.g. C-H center dot center dot center dot Cl and N-H center dot center dot center dot Cl) of one-dimensional band-like chain. These ligands and its butyltin complexes have growth effect on the target plants, such as Portulaca oleracea L., Amaranthus spinosus L., Cassia tora L., Brassica campestris L. ssp. chinensis var. utilis Tsen et Lee and Amaranthus tricolor L. The ligand L1 has a good inhibitory effect on the growth of Cassia tora L., and complex T2 has selective inhibition on the growth of Portulaca oleracea L. and Amaranthus tricolor L., which can be used as a candidate compound for Cassia tora L., Portulaca oleracea L. and Amaranthus tricolor L. herbicide.
摘要：
Porcine epidemic diarrhea(PED)is an acute intestinal infectious disease caused by porcine epidemic diarrhea virus(PEDV).PED occurs highly in ten days piglets,with a mortality rate of 100%.Colloidal gold immunochromatography assay and enzymelinked immunosorbent assay(ELISA)are the most widely used for the detection of PEDV.Both methods require natural antibodies whose activity are greatly affected by environmental factors seriously.So we prepare the artificial antibody of PEDV,a kind of nanomolecular imprinted polymers synthesized by solid reaction method with the epitope of PEDV as the template molecule.The antigen PEDV detected by artificial antibody through pseudo enzyme linked immunosorbent assay will be discussed.
