Synthesis of Anti-Epileptic Drug Retigabine Combined with Clinical Therapeutic Effect
作者：
Zeng, Zhiwen* ;Li, Xiang;Zhang, Fuxing
期刊：
INVESTIGACION CLINICA ,2020年61(3):1148-1155 ISSN：0535-5133
通讯作者：
Zeng, Zhiwen
作者机构：
[Zeng, Zhiwen] Hunan Polytech Environm & Biol, Dept Basic Courses, Hengyang 421005, Hunan, Peoples R China.;[Li, Xiang] Hunan Polytech Environm & Biol, Dept Med & Tech, Hengyang 421005, Hunan, Peoples R China.;[Zhang, Fuxing] Hengyang Normal Univ, Dept Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Zeng, Zhiwen] H;Hunan Polytech Environm & Biol, Dept Basic Courses, Hengyang 421005, Hunan, Peoples R China.
关键词：
Retigabine Synthesis;Clinical Response;Epilepsy
摘要：
Retigabine is a new type of drug widely used in the treatment of epilepsy and other symptoms. It is mainly used for adjuvant treatment of partial seizures in adults with refractory epilepsy. There are many synthetic processes of retigabine. However, retigabine can cause fatigue, dizziness, vertigo and even neurasthenia and hallucinations during clinical treatment. This article combines the patient's clinical response to develop the synthetic scheme of retigabine. And according to the side effects of adjuvant retigabine treatment. This article summarizes the various synthetic methods of retigabine and studies the new synthetic scheme of retigabine in combination with the clinical response.
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英文
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Two Novel Dibutyltin Complexes with Trimers and Hexanuclear Based on the Bis(5-Cl/Me-salicylaldehyde) Carbohydrazide:Syntheses,Structures,Fluorescent Properties and Herbicidal Activity
作者：
Feng Yong-Lan;Zhang Fu-Xing;Kuang Dai-Zhi* ;Yang Chun-Lin
期刊：
Chinese Journal of Structural Chemistry ,2020年39(4):682-692 ISSN：0254-5861
通讯作者：
Kuang Dai-Zhi
作者机构：
[Feng Yong-Lan; Kuang Dai-Zhi; Zhang Fu-Xing; Yang Chun-Lin] Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Funct Organometall Mat, Coll Hunan Prov,Dept Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Kuang Dai-Zhi] H;Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Funct Organometall Mat, Coll Hunan Prov,Dept Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
关键词：
bis(salicylaldehyde)carbohydrazidebutyltin;microwave solvothermal synthesis;crystal structure;fluorescence properties;herbicidal activity
摘要：
Two novel bis(2-hydroxy-5-R-benzylidene) carbohydrazide dibutyltin complexes (R: Cl (T1), Me (T2)) with hexanuclear and triangular frame structures were obtained by microwave-assisted solvothermal reaction of dibutyltin oxide precursor with the ligands in methanol environments, However, their structures are characterized by elemental analysis, IR, (H-1, C-13) NMR spectra, and the molecular structures of T1 and T2 were confirmed by X-ray diffraction. The crystal of T1 belongs to triclinic system, space group P (1) over bar, and T2 is of monoclinic system, space group C2/c. Five-coordinated distorted triangular bipyramids and six-coordinated distorted octahedral configurations were formed by the coordination of oxygen and nitrogen atoms of ligands with two dibutyltins, respectively, and trimer hexanuclear dibutyltin complexes were constructed by the cross-coordination of enol imines. The two complexes exhibit fluorescence emission in DMF solvents and DMF-water mixtures. When the volume fraction of water content is between 0 and 10% (V/V), the aggregation fluorescence enhancement effect is good, and fluorescence quenching occurs when the water content is more than 10% (V/V). The T1 can inhibit the growth of target plants, such as Portulaca oleracea, Cassia tora L., Brassica campestris L.ssp.chinensis var.utilis Tsen et Lee and Amaranthus tricolor L. The T2 can selectively inhibit the growth of Portulaca oleracea L., Amaranthus spinosus L. and Amaranthus tricolor L. It can be used as a candidate herbicide for Portulaca oleracea L., Amaranthus spinosus L. and Amaranthus tricolor L.
语种：
英文
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A synthesis route of an oral antidiabetic drug-linagliptin based on the removal of protective group
作者：
Zeng, Zhiwen* ;Li, Xiang;Zhang, Fuxing
期刊：
Acta Microscopica ,2020年29(1):244-250 ISSN：0798-4545
通讯作者：
Zeng, Zhiwen
作者机构：
[Zeng, Zhiwen] Hunan Polytech Environm & Biol, Dept Basic Courses, Hengyang 421005, Peoples R China.;[Li, Xiang] Hunan Polytech Environm & Biol, Dept Med & Tech, Hengyang 421005, Peoples R China.;[Zhang, Fuxing] Hengyang Normal Univ, Dept Chem & Mat Sci, Hengyang 421008, Peoples R China.
通讯机构：
[Zeng, Zhiwen] H;Hunan Polytech Environm & Biol, Dept Basic Courses, Hengyang 421005, Peoples R China.
关键词：
Hypoglycemic effect;Linagliptin;Substitution reaction;Synthesis
摘要：
In this paper, a synthetic route of oral antidiabetic drug-linagliptin based on the removal of protective group was studied. The key intermediate was obtained from methyl urea by 6 steps of cyclization, nitrosation, reduction, cyclization, Bromination and substitution. The intermediate 2-chloromethyl-4-methylouwarin was synthesized from o-aminoacetophenone by condensation, cyclization and reduction. Based on these two intermediates, linagliptin was prepared by a series of substitution reactions. The experimental results show that the synthesis efficiency of this method is high. In addition, the raw material of the synthesis method is cheap and easy to obtain, the reaction conditions are mild, and the post-treatment is simple, which lays a foundation for industrial production. © 2020, Interamerican Society for Electron Microscopy (CIASEM). All rights reserved.
语种：
英文
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双(取代水杨醛)缩卡巴肼及其苄基锡配合物的合成、表征、荧光性质和除草活性
作者：
Feng Yong-Lan;Yang Chun-Lin;Zhang Fu-Xing;Kuang Dai-Zhi*
期刊：
无机化学学报 ,2019年35(10):1737-1745 ISSN：1001-4861
通讯作者：
Kuang Dai-Zhi
作者机构：
[Feng Yong-Lan; Kuang Dai-Zhi; Zhang Fu-Xing; Yang Chun-Lin] Hengyang Normal Univ, Coll Chem & Mat Sci, Coll Hunan Prov, Key Lab Funct Organometall Mat,Key Lab Funct Met, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Kuang Dai-Zhi] H;Hengyang Normal Univ, Coll Chem & Mat Sci, Coll Hunan Prov, Key Lab Funct Organometall Mat,Key Lab Funct Met, Hengyang 421008, Hunan, Peoples R China.
关键词：
双(取代水杨醛)缩卡巴肼;苄基锡配合物;荧光性质;除草活性
摘要：
用5-甲基水杨醛、4-二乙氨基水杨醛分别与卡巴肼或硫代卡巴肼缩合,制得1,5-二取代卡巴肼或硫代卡巴肼配体。在微波甲醇溶剂热条件下,二苄基二氯化锡前体与配体反应,合成了双(取代水杨醛)缩(硫代)卡巴肼苄基锡配合物T1~T4,但T4的结构与T1~T3不同,T4由N,N′-双(4-二乙氨基水杨醛)缩连氮及甲氧基桥联锡组成的苄基锡配合物,T4还可由卡巴肼、4-二乙氨基水杨醛和二苄基二氯化锡“一锅法”合成。T1~T4的结构经元素分析、IR、~1H/~(13)C NMR表征,并用X射线衍射法确证配合物T4的晶体分子结构。T4属单斜晶系,P2_1/c空间群,中心锡原子与氮、氧、苄基碳和氯原子组成六配位变形八面体构型。T4在DMF-H_2O溶液中具有良好的荧光性质,当含水量0~30%(V/V)时具有聚集荧光增强效应,含水量大于30%时,随含水体积分数增加荧光强度减弱,以至最后淬灭。配合物对马齿苋具有良好的生长抑制作用,T1和T3对决明子、T2对苋菜和T4对四九菜心具有选择性生长抑制作用,可作为除草剂的候选化合物进一步研究。
语种：
中文
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两个有机锡羟基苯甲酸酯配合物的合成、结构及抗癌活性
作者：
Zhang Fu-Xing* ;He Tang-Feng;Yao Shu-Fen;Zhu Xiao-Ming;Sheng Liang-Bing;...
期刊：
无机化学学报 ,2019年35(4):598-604 ISSN：1001-4861
通讯作者：
Zhang Fu-Xing
作者机构：
[Sheng Liang-Bing; Yao Shu-Fen; Jiang Wu-Jiu; Feng Yong-Lan; Kuang Dai-Zhi; Zhang Fu-Xing; He Tang-Feng; Yu Jiang-Xi; Zhu Xiao-Ming] Hengyang Normal Univ, Dept Chem & Mat Sci, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Funct Organometall Mat Coll Hunan Prov, Hengyang 421008, Human, Peoples R China.
通讯机构：
[Zhang Fu-Xing] H;Hengyang Normal Univ, Dept Chem & Mat Sci, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Funct Organometall Mat Coll Hunan Prov, Hengyang 421008, Human, Peoples R China.
关键词：
有机锡羟基苯甲酸酯;晶体结构;量子化学;体外抗肿瘤活性
摘要：
合成了2个有机锡羟基苯甲酸酯配合物:梯形结构的二(对氯苄基)锡邻羟基苯甲酸酯[(μ_3-O)(μ_2-OH)(p-Cl~-C_6H_4CH_2Sn)_2 (O_2CC_6H_4-OH-o)]_2 (1)和三苯基锡二(对羟基苯甲酸)酯(2)。通过元素分析、红外光谱、差热分析、X射线单晶衍射等方法对配合物进行了结构表征,并对其进行了量子化学从头计算和体外抗癌活性研究。结果显示:配合物1为具有Sn_2O_2构筑的3个平面四元环组成的梯形骨架结构,配合物2为单锡核结构,锡原子均为五配位的畸变三角双锥构型;配合物对人结肠癌细胞(HT-29)、肝癌细胞(HepG2)、乳腺癌细胞(MCF-7)、宫颈癌细胞(Hela)和肺癌细胞(A549)均显示出比临床使用的顺铂更强的抗癌活性。
语种：
中文
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Heteronuclear and homonuclear Ni(II) complexes constructed based on 8-hydroxyquinoline-2-carbaldehyde oxime: Structure and its behavior in solution
作者：
Sheng, Liang-Bing* ;Zhang, Fu-Xing;Liu, Meng-Qin;Chen, Man-Sheng*
期刊：
Polyhedron ,2019年173:114108 ISSN：0277-5387
通讯作者：
Sheng, Liang-Bing;Chen, Man-Sheng
作者机构：
[Zhang, Fu-Xing; Sheng, Liang-Bing; Chen, Man-Sheng; Liu, Meng-Qin] Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Hunan Prov Univ Key Lab Funct Organometall Mat, Coll Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Sheng, LB; Chen, MS] H;Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Hunan Prov Univ Key Lab Funct Organometall Mat, Coll Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
关键词：
Electrospray-ionization mass spectrometry;Heteronuclear;Homonuclear;One-dimensional chain;Structure
摘要：
The organic ligand (E)-8-hydroxyquinoline-2-carbaldehyde oxime (H2L) was used to react with Ni(CH3COO)(2)center dot 4H(2)O and NaN(CN)(2) at 100 degrees C to obtain the complex [Ni3Na(HL)(3)(L)(2)](n)center dot 4nCH(3)CN (1). Interestingly, the five ligands in the structure chelate three Ni ions, and the uncoordinated O on the ligand captures one Na+. However, the above scheme remains the same, and after adding isonicotinic acid (ina), it obtained the complex [Ni-4(HL)(4)(L)(2)](2)center dot 2CH(3)CN (2), which eight Ni2+ ions are coordinated by twelve ligands. The component distribution of the complexes in different solutions was measured by electrospray-ionization mass spectrometry (ESI-MS). It was found that the complexes exhibited different component distribution in different solutions. Not only the existence of low-nuclear molecular ion peaks could be monitored, but even higher-nuclear components could also be detected, and the alkali metal ions could be effectively identified. It was indicating that the compounds would assemble differently in different solutions. Surprisingly, homonuclear clusters 2 was providing a basis for further directing the directed synthesis of higher nuclear clusters. (C) 2019 Published by Elsevier Ltd.
语种：
英文
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Syntheses,Structures and Herbicidal Activity of Bis(5-R-2-hydroxybenzylidene)Thiocarbohydrazide Monobutyltin Complexes [R:H(T1),Me(T2)]
作者：
Feng Yong-Lan;Zhang Fu-Xing;Kuang Dai-Zhi*
期刊：
Chinese Journal of Structural Chemistry ,2019年38(5):719-726 ISSN：0254-5861
通讯作者：
Kuang Dai-Zhi
作者机构：
[Feng Yong-Lan; Kuang Dai-Zhi; Zhang Fu-Xing] Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Funct Organometall Mat, Coll Hunan Prov,Dept Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Kuang Dai-Zhi] H;Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Funct Organometall Mat, Coll Hunan Prov,Dept Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
关键词：
bis(2-hydroxybenzylidene)thiocarbohydrazide butyltin;microwave solvothermal synthesis;crystal structure;herbicidal activity
摘要：
The 1,5-disubstituted thiocarbohydrazide ligands were prepared by the condensation of thiocarbohydrazide with salicylaldehyde and 5-methylsalicylaldehyde, respectively. The butyltin complexes, [(5-R-2-hydroxy)ArCH=NNH](2)CS(n-BuSnCl)(2), R = H(T1); R = Me(T2), based on the 1,5-disubstituted thiocarbohydrazide were obtained by microwave-assisted solvothermal reaction of n-butyltintrichloride precursor with the ligands in methanol environments, which have been structurally characterized by elemental analysis, IR and (H-1,C-13) NMR spectra. The crystals belong to monoclinic system, space groups C2/c(T1) and Pc(T2), respectively. The Sn atom is six-coordinated with distorted octahedral geometry by 0, N and S atoms from ligand, C atom of butyl and two Cl atoms. In the crystal, complex T1 forms three-dimensional supramolecular assembly mediated by noncovalent interactions such as C-H center dot center dot center dot Cl and pi-stacking interactions. Similarly, T2 forms an interesting two-dimensional supramolecular structure by noncovalent interactions (e.g. C-H center dot center dot center dot Cl and N-H center dot center dot center dot Cl) of one-dimensional band-like chain. These ligands and its butyltin complexes have growth effect on the target plants, such as Portulaca oleracea L., Amaranthus spinosus L., Cassia tora L., Brassica campestris L. ssp. chinensis var. utilis Tsen et Lee and Amaranthus tricolor L. The ligand L1 has a good inhibitory effect on the growth of Cassia tora L., and complex T2 has selective inhibition on the growth of Portulaca oleracea L. and Amaranthus tricolor L., which can be used as a candidate compound for Cassia tora L., Portulaca oleracea L. and Amaranthus tricolor L. herbicide.
语种：
英文
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Microwave assisted synthesis of disubstituted benzyltin arylformylhydrazone complexes: anticancer activity and DNA-binding properties
作者：
Jiang, Wu-Jiu* ;Zhou, Qian;Liu, Meng-Qin;Zhang, Fu-Xing;Kuang, Dai-Zhi;...
期刊：
Applied Organometallic Chemistry ,2019年33(9):ARTN e5092 ISSN：0268-2605
通讯作者：
Jiang, Wu-Jiu;Tan, Yu-Xing
作者机构：
[Jiang, WJ; Tan, Yu-Xing; Jiang, Wu-Jiu; Zhang, Fu-Xing; Kuang, Dai-Zhi; Liu, Meng-Qin] Hengyang Normal Univ, Univ Hunan Prov, Coll Chem & Mat Sci, Key Lab Funct Met Organ Cpds Hunan Prov,Key Lab F, Hengyang 421008, Hunan, Peoples R China.;[Zhou, Qian] Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China.
通讯机构：
[Jiang, WJ; Tan, YX] H;Hengyang Normal Univ, Univ Hunan Prov, Coll Chem & Mat Sci, Key Lab Funct Met Organ Cpds Hunan Prov,Key Lab F, Hengyang 421008, Hunan, Peoples R China.
关键词：
biological activity;crystal structure;hydrazone;organotin;synthesis
摘要：
Eight disubstituted benzyltin complexes, i.e., {[R(O)C=N-N=C (Me)COO]R'2Sn(CH3OH)}n (1a and 2b), {[R(O)C=N-N=C (Me)COO]R'2Sn(CH3OH)}2 (1b and 1d) and {[R(O)C=N-N=C (Me)COO]R'2Sn}n (1c, 2a, 2c, and 2d) (R=C4H3O-, C4H3S-, p–t-Bu-C6H4- or p-MeO-C6H4-; R'=o-Cl-C6H4CH2- or o-Me-C6H4CH2-), were prepared from the reaction of arylformylhydrazine, pyruvic acid and disubstituted benzyltin dichloride with microwave irradiation. All complexes were characterized by FT-IR spectroscopy, 1H, 13C and 119Sn NMR spectroscopy, HRMS, elemental analysis, X-ray single-crystal diffraction and TGA. The in vitro antitumour activities of all complexes were evaluated by an MTT assay against three human cancer cell lines (NCI-H460, HepG2, and MCF7). 2b exhibited strong antitumour activity on HepG2 cells and was expected to be a suitable platform for further chemical optimization to develop as anticancer therapeutics. The DNA binding of 2b was studied by UV–visible absorption spectrometry, fluorescence competitive assays, viscosity measurements and gel electrophoresis. Molecular docking was used to predict the binding between 2b and DNA, and the results show that 2b can become embedded in the double helix of DNA and cleave DNA. © 2019 John Wiley & Sons, Ltd.
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英文
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基于取代苯甲酰肼缩丙酮酸配体的二苄基锡配合物的合成、晶体结构及生物活性
作者：
Luo Bo;Yu Hao-Tian;Liu Meng-Qin;Zhang Fu-Xing;Kuang Dai-Zhi;...
期刊：
无机化学学报 ,2019年35(7):1212-1220 ISSN：1001-4861
通讯作者：
Jiang Wu-Jiu
作者机构：
[Yu Hao-Tian; Luo Bo; Jiang Wu-Jiu; Kuang Dai-Zhi; Zhang Fu-Xing; Liu Meng-Qin; Tan Yu-Xing] Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Funct Organometall Mat,Univ Hunan Prov, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Jiang Wu-Jiu] H;Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Funct Organometall Mat,Univ Hunan Prov, Hengyang 421008, Hunan, Peoples R China.
关键词：
有机锡配合物;酰腙;合成;晶体结构;生物活性
摘要：
二苄基二氯化锡分别与对甲氧基苯甲酰肼缩丙酮酸及对硝基苯甲酰肼缩丙酮酸反应,合成了2个二苄基锡配合物(C1、 C2),通过元素分析、IR、~1H NMR、~(13)C NMR、~(119)Sn NMR、HRMS以及X射线单晶衍射等表征了配合物结构.测试了配合物C1、C2的热稳定性以及配合物对癌细胞H460、HepG2、MCF7的体外抑制活性;在Tris-HCl缓冲溶液中,以EB做为荧光探针,用荧光光谱法初步研究了配合物C1与小牛胸腺DNA的相互作用;并且用凝胶电泳法研究了配合物C1切割质粒DNA pBR322的能力.结果表明:配合物C1、C2对3种癌细胞都有较好的抑制作用,但是C1更优于C2;配合物C1与小牛胸腺DNA作用是插入结合作用所致,能有效的将超螺旋DNA pBR322切割成缺刻型DNA.
语种：
中文
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具有聚集荧光增强性质的双(4-二乙氨基水杨醛)缩偶氮二甲酰肼二丁基锡的合成和晶体结构
作者：
Feng Yong-Lan;Kuang Dai-Zhi* ;Zhang Fu-Xing;Yu Jiang-Xi;Jiang Wu-Jiu;...
期刊：
无机化学学报 ,2019年35(2):307-313 ISSN：1001-4861
通讯作者：
Kuang Dai-Zhi
作者机构：
[Jiang Wu-Jiu; Feng Yong-Lan; Kuang Dai-Zhi; Zhang Fu-Xing; Yu Jiang-Xi; Zhu Xiao-Ming] Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Funct Organometall Mat, Coll Hunan Prov,Coll Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Kuang Dai-Zhi] H;Hengyang Normal Univ, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Funct Organometall Mat, Coll Hunan Prov,Coll Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China.
关键词：
双(4-二乙氨基水杨醛)缩偶氮二甲酰肼;丁基锡配合物;晶体结构;荧光性质
摘要：
在甲醇溶液中,卡巴肼、(4-二乙氨基)水杨醛和二乙酸二丁基锡“一锅法”反应,合成了一个新颖的基于双(4-二乙氨基水杨醛)缩偶氮二甲酰肼(L)的七配位有机锡配合物[Sn(L)(n-butyl)_2]_n(T).经元素分析、IR、(~1H,~(119)Sn,~(13)C)NMR和X射线衍射晶体结构表征,T的晶体属单斜晶系C2/c空间群,中心锡周围由双(4-二乙氨基水杨醛)缩偶氮二甲酰肼的O,N配位原子占据赤道位置和2个丁基占据顶端位置形成畸变五角双锥构型.通过烯醇式氧原子的桥联配位作用,T向一维带状无限扩展产生“竹筏状”超分子结构.配合物T在二甲基甲酰胺、四氢呋喃、乙醇、甲醇和甲苯有机溶剂及其有机溶剂-水混合物中具有强荧光发射峰,当含水量的体积分数在0~10%(V/V)时具有良好的聚集荧光增强效应,含水量大于10%(V/V)时发生荧光淬灭.
语种：
中文
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Synthesis, structure and biological activity of diphenyltin complexes based on O,N,O-tridentate ligands
作者：
Yu, Haotian;Tan, Yuxing;Kuang, Daizhi;Zhang, Fuxing;Jiang, Wujiu*
期刊：
Inorganica Chimica Acta ,2019年496:119044 ISSN：0020-1693
通讯作者：
Jiang, Wujiu
作者机构：
[Jiang, Wujiu; Tan, Yuxing; Zhang, Fuxing; Yu, Haotian; Kuang, Daizhi] Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Met Organ Cpds Hunan Prov, Univ Hunan Prov,Key Lab Funct Organometall Mat, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Jiang, Wujiu] H;Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Met Organ Cpds Hunan Prov, Univ Hunan Prov,Key Lab Funct Organometall Mat, Hengyang 421008, Hunan, Peoples R China.
关键词：
Biological activity;Crystal structure;Hydrazone;Organotin;Synthesis
摘要：
Three new diphenyltin complexes, {[p-t-Bu-C6H4(O)C[dbnd]N–N[dbnd]C(Me)COO]Ph2Sn(MeOH)}2 (C1), {[p-MeO-C6H4(O)C[dbnd]N–N[dbnd]C(Me)COO]Ph2Sn(MeOH)}2 (C2) and {[C4H3O(O)C[dbnd]N–N[dbnd]C(Me)COO]Ph2Sn}n (C3), were synthesized by the reactions of diphenyltin dichloride with the corresponding hydrazones. All the complexes were characterized by IR; 1H, 13C, and 119Sn NMR spectroscopy; HRMS; elemental analysis; single-crystal X-ray diffraction and TGA. To test their in vitro antitumour activities, the complexes were evaluated by an MTT assay, and that C3 exhibited better antitumour activity than C1 or C2. The interaction between C3 and DNA was studied by UV–visible absorption spectroscopy and fluorescence spectroscopy. The complex intercalated into DNA, which is consistent with the results of molecular docking. © 2019 Elsevier B.V.
语种：
英文
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微波辅助自组装合成有机锡配合物及其生物活性
作者：
蒋伍玖;谭宇星;邝代治;张复兴;刘梦琴
期刊：
中国科学：化学 ,2019年49(8):1083-1093 ISSN：1674-7224
作者机构：
衡阳师范学院化学与材料科学学院,功能金属有机材料湖南省普通高等学校重点实验室,功能金属有机化合物湖南省重点实验室,衡阳421008;[邝代治; 刘梦琴; 谭宇星; 蒋伍玖; 张复兴] 衡阳师范学院
关键词：
有机锡配合物;酰腙;合成;晶体结构;生物活性
摘要：
利用微波“一锅法”合成了4个有机锡配合物(C1~C4),通过红外光谱(IR)、紫外可见吸收光谱(Vis- UV)、~1H NMR、~(13)C NMR、~(119)Sn NMR、高分辨率质谱(HRMS)、X射线单晶衍射以及热重分析等表征了配合物的结构.结构分析表明,配合物C1~C4均为中心对称的平面Sn_2O_2四元环结构.通过MTT法,测试了配合物C1~C4对癌细胞NCI-H460、HepG2、MCF7以及正常人体肝细胞HL7702的体外抑制活性,结果显示,配合物C1对3种癌细胞的抑制活性优于其他配合物及卡铂,有望成为金属有机抗癌药物候选化合物.通过紫外光谱、荧光光谱、黏度、分子对接实验,证实了配合物C1与DNA的相互作用是插入结合方式.
语种：
中文
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基于六氯合锡阴离子构筑的有机-无机超分子杂合物YSnCl6[Y:H2TEDA,（HDEA）2,H2DAP]的制备和结构
作者：
邝代治;张复兴;庾江喜;蒋伍玖;朱小明
期刊：
衡阳师范学院学报 ,2019年40(03):33-39 ISSN：1673-0313
作者机构：
功能金属有机化合物湖南省重点实验室,功能金属有机材料湖南省普通高等学校重点实验室,衡阳师范学院 化学与材料科学学院,湖南 衡阳 421008;[庾江喜; 邝代治; 蒋伍玖; 朱小明; 张复兴] 功能金属有机材料湖南省普通高等学校
关键词：
三乙烯二胺（TEDA）;二乙胺（DEA）;2,3-二氨基吩嗪（DAP）;六氯合锡阴离子;有机-无机杂合物;超分子结构
摘要：
在盐酸水-甲醇介质中,三乙烯二胺(TEDA)、二乙胺(DEA)和由邻苯二胺(OPD)自缩合形成的 2,3-二氨基吩嗪(DAP)发生质子化形成有机铵阳离子,四氯化锡转化为六氯合锡阴离子.通过氢键和离子对作用,有机铵阳离子与六氯合锡阴离子自组装成有机-无机超分子杂合物,[(H2 TEDA)(SnCl6 )](1 ),[(HDEA)2 (SnCl6 )](2),[(H2 DAP)(SnCl6 )](3).杂合物的晶体分子结构经 X-射线衍射方法测定确证.化合物(1 )和(3)的晶体属于三斜晶系,分别为P-1 和P1 空间群,化合物(2)的晶体属于单斜晶系,P2(1)/n 空间群.晶体中,六氯合锡阴离子具有变形八面体构型,有机组分与无机组分穿插排列,形成(1 )和(3 )三维、(2 )为二维的超分子结构,为进一步新材料研究奠定基础.
语种：
中文
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一种三(邻溴苄基)锡苯基丙烯酸酯及制备方法与应用
发明/设计人：
张复兴
申请/专利权人：
衡阳师范学院
申请/专利号：
CN201810709563.6
申请时间：
2018-07-02
公开号：
CN109134528A
公开时间：
2019-01-04
主申请人地址：
421008 湖南省衡阳市雁峰区黄白路165号
摘要：
本发明公开的一种三(邻溴苄基)锡苯基丙烯酸酯，为如下结构式的化合物。本发明选择三(邻溴苄基)氧化锡与配体苯丙烯酸，在一定条件下反应，合成得到了对人乳腺癌细胞(MCF7)细胞株、人肺癌细胞(A549)和人肺癌细胞(H460)具有较强抑制活性的化合物三(邻溴苄基)锡苯基丙烯酸酯，为开发抗癌药物提供了新途径。
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大环超分子二(三环己基锡)吡啶-二甲酸酯的合成、结构和抗癌活性
作者：
Kuang Dai-Zhi* ;Yu Jiang-Xi;Feng Yong-Lan;Zhu Xiao-Ming;Jiang Wu-Jiu;...
期刊：
无机化学学报 ,2018年34(6):1035-1042 ISSN：1001-4861
通讯作者：
Kuang Dai-Zhi
作者机构：
[Jiang Wu-Jiu; Feng Yong-Lan; Kuang Dai-Zhi; Zhang Fu-Xing; Yu Jiang-Xi; Zhu Xiao-Ming] Hengyang Normal Univ, Key Lab Funct Organometall Mat, Coll Hunan Prov, Key Lab Funct Met Organ Cpds Hunan Prov,Coll Chem, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Kuang Dai-Zhi] H;Hengyang Normal Univ, Key Lab Funct Organometall Mat, Coll Hunan Prov, Key Lab Funct Met Organ Cpds Hunan Prov,Coll Chem, Hengyang 421008, Hunan, Peoples R China.
关键词：
三环己基锡吡啶二甲酸酯;微波溶剂热合成;结构;体外抗肿瘤活性
摘要：
在微波溶剂热中,三环己基氢氧化锡分别与2,6-H_2pydc和3,5-H_2pydc(H_2pydc=吡啶二甲酸)反应,合成了4个二(三环己基锡)吡啶-二甲酸酯:{[(2,6-Hpydc)SnCy_3]·MeOH}_n (1)、[(2,6-pydc)Sn_2Cy_6(H_2O)]·PhH (2)、[(3,5-pydc)Sn_2Cy_6(MeOH)]·MeOH (3)和[(3,5-pydc)Sn_2Cy_6(H_2O)]·EtOH (4)。对它们的组成和结构进行了元素分析、IR、(~1H,~(13)C和~(119)Sn)NMR和单晶X射线衍射表征。化合物中心锡与配基原子构成畸形四、六面体构型,由于氢键作用,化合物形成二维大环网状超分子结构。初步探索了1、3对人结肠癌(HT-29)、肝癌细胞(HepG2)、乳腺癌(MCF-7)、鼻咽癌(KB)和肺癌细胞(A549)的增殖抑制活性,结果表明化合物具有广谱和较强的抗癌作用。
语种：
中文
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三个二(有机锡)吡啶-2,3(5)-二甲酸酯的合成、结构和体外抗癌活性
作者：
Feng Yong-Lan;Yu Jiang-Xi;Jiang Wu-Jiu;Zhu Xiao-Ming;Zhang Fu-Xing;...
期刊：
无机化学学报 ,2018年34(1):99-104 ISSN：1001-4861
通讯作者：
Kuang Dai-Zhi
作者机构：
[Jiang Wu-Jiu; Feng Yong-Lan; Kuang Dai-Zhi; Zhang Fu-Xing; Yu Jiang-Xi; Zhu Xiao-Ming] Hengyang Normal Univ, Coll Hunan Prov, Coll Chem & Mat Sci, Key Lab Funct Organometall Mat, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Kuang Dai-Zhi] H;Hengyang Normal Univ, Coll Hunan Prov, Coll Chem & Mat Sci, Key Lab Funct Organometall Mat, Hengyang 421008, Hunan, Peoples R China.
关键词：
有机锡吡啶甲酸酯;微波溶剂热合成;体外抗肿瘤活性
摘要：
在微波溶剂热中,三环已基氢氧化锡、氧化双(三((2-甲基-2-苯基)丙基)锡)与吡啶-2,3(5)-二甲酸反应,合成了3个双核二(有机锡)吡啶-2,3(5)-二甲酸酯:Py(CO)_2(SnR_3)_2(MeOH)_n(R:Cy,n=1(1),2(2);R:PhCMe_2CH_2,n=0(3)),对它们的组成和结构进行了元素分析、IR、(~1H,~(13)C,~(119)Sn)NMR和X射线晶体衍射分析表征,化合物中心锡与配基原子构成畸形四/六面体构型,由于氢键作用,化合物1形成一维链,2形成二维34元大环网状结构.化合物对人结肠癌(HT-29)、肝癌细胞(HepG2)、乳腺癌(MCF-7)、鼻咽癌(KB)和肺癌细胞(A549)的增殖有较强的抑制作用.
语种：
中文
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1-(水杨醛)-5-(香草醛)缩卡巴肼丁基锡配合物的合成、结构、谱学性质和除草活性
作者：
Feng Yong-Lan;Zhang Fu-Xing;Yu Jiang-Xi;Jiang Wu-Jiu;Kuang Dai-Zhi*
期刊：
无机化学学报 ,2018年34(10):1857-1863 ISSN：1001-4861
通讯作者：
Kuang Dai-Zhi
作者机构：
[Jiang Wu-Jiu; Feng Yong-Lan; Kuang Dai-Zhi; Zhang Fu-Xing; Yu Jiang-Xi] Hengyang Normal Univ, Dept Chem & Mat Sci, Coll Hunan Prov, Key Lab Funct Met Organ Cpds Hunan Prov,Key Lab F, Hengyang 421008, Hunan, Peoples R China.
通讯机构：
[Kuang Dai-Zhi] H;Hengyang Normal Univ, Dept Chem & Mat Sci, Coll Hunan Prov, Key Lab Funct Met Organ Cpds Hunan Prov,Key Lab F, Hengyang 421008, Hunan, Peoples R China.
关键词：
5-不对称二取代卡巴肼;丁基锡配合物;晶体结构;荧光性质;除草活性
摘要：
卡巴肼分别与水杨醛和香草醛缩合制备1,5-不对称二取代卡巴肼配体,在甲醇溶剂热中,正丁基三氯化锡与配体反应,合成1-(水杨醛)-5-(香草醛)缩卡巴肼丁基锡配合物(B1)和含N,N′-双水杨醛缩连氮分子的丁基锡配合物(B2),经元素分析,IR, ~1H、~(119)Sn、~(13)C NMR和X射线衍射晶体结构表征,配合物(B1)、(B2)晶体分别属单斜晶系、P2_1/n空间群和三斜晶系、P1空间群,中心锡与配基原子构成六配位畸形八面体构型,配合物(B1)在DMF-H_2O溶剂体系中具有良好的荧光性质,当含水0~10%(V/V)时具有聚集荧光增强效应,含水量大于10%,随含水体积分数增加荧光强度减弱,以至最后淬灭。配体及其配合物(B1)对马齿苋、刺苋、决明子、四九菜心和苋菜5种靶标植物均具有一定生长抑制作用,尤其是配体对马齿苋、刺苋的生长有良好的抑制作用,配合物可以选择性抑制决明子的生长,可作为决明子除草剂的候选化合物。
语种：
中文
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New detecting materials for porcine epidemic diarrhea virus
作者：
Siping Tang;Qinghai Tang;Zhifeng Xu;Biao Gu;Fuxing Zhang
作者机构：
[Siping Tang; Qinghai Tang; Zhifeng Xu; Biao Gu; Fuxing Zhang] Department of Chemistry and Material Science, Hengyang Normal University
会议名称：
第四届先进材料国际会议
会议时间：
2018-11-15
会议地点：
江苏镇江
会议论文集名称：
第四届先进材料国际会议论文集
关键词：
Porcine epidemic diarrhea virus;Molecular imprinted polymers;Artificial antibody
摘要：
Porcine epidemic diarrhea(PED)is an acute intestinal infectious disease caused by porcine epidemic diarrhea virus(PEDV).PED occurs highly in ten days piglets,with a mortality rate of 100%.Colloidal gold immunochromatography assay and enzymelinked immunosorbent assay(ELISA)are the most widely used for the detection of PEDV.Both methods require natural antibodies whose activity are greatly affected by environmental factors seriously.So we prepare the artificial antibody of PEDV,a kind of nanomolecular imprinted polymers synthesized by solid reaction method with the epitope of PEDV as the template molecule.The antigen PEDV detected by artificial antibody through pseudo enzyme linked immunosorbent assay will be discussed.
语种：
英文
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Synthesis, crystal structure and anticancer activity of the dibutyltin(IV)oxide complexes containing substituted salicylaldehyde-o-aminophenol Schiff base with appended donor functionality
作者：
Zhang, Zhi-Jian;Zeng, Hui-Ting;Liu, Yang;Kuang, Dai-Zhi;Zhang, Fu-Xing;...
期刊：
Inorganic and Nano-Metal Chemistry ,2018年48(10):486-494 ISSN：2470-1556
通讯作者：
Tan, Yu-Xing;Jiang, Wu-Jiu
作者机构：
[Tan, Yu-Xing; Jiang, WJ; Zhang, Fu-Xing; Jiang, Wu-Jiu; Kuang, Dai-Zhi; Liu, Yang; Zhang, Zhi-Jian] Hengyang Normal Univ, Coll Chem & Mat Sci, Univ Hunan Prov, Key Lab Funct Met Organ Cpds Hunan Prov,Key Lab F, Hengyang 421008, Hunan, Peoples R China.;[Zeng, Hui-Ting] Sch Med Technol, Hengyang, Hunan Polytech Environm & Biol, Hengyang, Hunan, Peoples R China.
通讯机构：
[Tan, YX; Jiang, WJ] H;Hengyang Normal Univ, Coll Chem & Mat Sci, Univ Hunan Prov, Key Lab Funct Met Organ Cpds Hunan Prov,Key Lab F, Hengyang 421008, Hunan, Peoples R China.
关键词：
anticancer activity;crystal structure;organotin;Schiff base;synthesis
摘要：
Schiff base butyltin complexes C1 ∼ C3 have been synthesized via the reaction of dibutyltin oxide with the substituted salicylaldehyde-o-aminophenol Schiff base ligands (L1 ∼ L3), respectively. The complexes have been characterized by elemental analysis, IR, UV-Vis, 1 H NMR, 13C NMR spectra and the crystal structures have been determined by X-ray diffraction. The anticancer activity of the Schiff base ligands L1 ∼ L3 and complexes C1 ∼ C3 against five species of cancer cells which are MCF7, Colo205, NCI-H460, Hela and HepG2 were tested respectively, the tests showed that C3 exhibited significant anticancer activity for the cancer cells in comparison with other complexes. The interaction between C3 and calf thymus DNA were studied by fluorescence, UV-Vis and Viscosity experiment, the results show that the interaction of C3 with calf thymus DNA was intercalation. © 2019, © 2019 Taylor & Francis Group, LLC.
语种：
英文
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双(取代水杨醛)缩卡巴肼正丁基锡配合物的合成、结构及除草活性
作者：
杨春林;冯泳兰;张复兴;庾江喜;蒋伍玖;...
期刊：
应用化学 ,2018年35(7):795-801 ISSN：1000-0518
作者机构：
衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省高校重点实验室, 湖南, 衡阳, 421008;湘潭大学化学学院, 湖南, 湘潭, 411100;[杨春林] 衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省高校重点实验室, 湖南, 衡阳, 421008 湘潭大学化学学院, 湖南, 湘潭, 411100;[冯泳兰; 张复兴; 庾江喜; 蒋伍玖; 邝代治] 衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省高校重点实验室, 湖南, 衡阳, 421008
关键词：
双(取代水杨醛)缩卡巴肼丁基锡配合物;晶体结构;除草活性
摘要：
在微波甲醇溶剂热中,正丁基三氯化锡(n-BuSnCl_3)与双[4-二乙氨基或(3,5-二叔丁基)取代水杨醛]缩卡巴肼和缩硫代卡巴肼配体反应,合成双(取代水杨醛)缩卡巴肼和缩硫代卡巴肼丁基锡配合物,(n-BuSn)_2Cl_3(OH_2)[(2-OH,R) PhCH=NNH]_2CX[R: 4-NEt_2(4-二乙氨基),X: O(A1); R: 4-NEt_2,X: S(A2); R: 3,5-(t-Bu)_2,X: O(A3); R: 3,5-(t-Bu)_2,X: S(A4)],经元素分析、IR、~1H和~(13)C NMR表征,X射线衍射获得的配合物A2的晶体结构表明,化合物A2是具有六配位畸形八面体构型的双锡核配合物。配体及其丁基锡配合物均对马齿苋、刺苋、四九菜心、苋菜和决明子靶标植物具有生长抑制作用,且配合物A1和A2具有较广谱、配合物A3和A4具有选择性生长抑制作用,可作为杂草生长抑制候选物研究。
语种：
中文
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